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Anticancer Plants: Clinical Trials and Nanotechnology pp 233–252Cite as

Recent Advancements in the Clinical Evaluation of Plant-Derived Anticancer Compounds

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Abstract

Cancer is a chief global health burden and the leading cause of human death worldwide next to heart diseases. The alarming rise in the mortality rate owing to cancer has driven the chase for anticancer agents to effectively combat this disease. Searching for novel and efficient compounds of natural origin has been a major aspect of concerns because they exhibit less toxic side effects. Numerous secondary metabolites from plants and their semisynthetic analogs have been identified as an excellent, novel lead structures in developing promising anticancer agents. In the current scenario, several successful anticancer drugs and their derivatives have been obtained from plant sources, and many of them are in clinical trials. Phytocompounds such as vinca alkaloids, taxanes, podophyllotoxin, camptothecin, homoharringtonine, and their derivatives have appreciably influenced cancer research on many facets. Likewise, some of the other plant-derived anticancer agents including omacetaxine mepesuccinate, ingenol mebutate, β-lapachone, flavopiridol, curcumin, etc. are currently being under phase I and II clinical trials, either individually or in concert with other anticancer agents for the treatment of a broad range of tumors like lymphomas, leukemias, and solid tumors. Customary anticancer drug discovery has targeted mainly on the cytotoxic agents that hamper metabolic pathways critical to cell division. However, during recent years, several molecular target-based compounds have been emerged concentrating on other cellular process of cancer cells such as apoptosis, metastasis, angiogenesis, etc. Hence, the present anticancer drug discovery involves high-throughput screening of phytocompounds against a series of such molecular targets. The present chapter discusses the clinical evidences of some important phytocompounds of anticancer plants, overview of their current clinical status, and recent advances in their molecular mechanism of action.

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Authors and Affiliations

  1. Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 004, Tamil Nadu, India

    Jayabalan Shilpha, Lakkakula Satish & Manikandan Ramesh

  2. Department of Biotechnology Engineering, Ben-Gurion University of Negev, Beer Sheva, 84105, Israel

    Lakkakula Satish

  3. The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Bergman Campus, Beer Sheva, 84105, Israel

    Lakkakula Satish

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  1. Jayabalan Shilpha
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  2. Lakkakula Satish
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Editors and Affiliations

  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Shilpha, J., Satish, L., Ramesh, M. (2017). Recent Advancements in the Clinical Evaluation of Plant-Derived Anticancer Compounds. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Clinical Trials and Nanotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-8216-0_8

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