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Anticancer Plants: Clinical Trials and Nanotechnology pp 203–231Cite as

Toxicological and Pharmacological Use of Anticancer Compounds

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Abstract

Knowledge of medicinal plants from traditional medicinal drug therapy has brought limitless implications towards the discovery of novel compounds for modern therapeutic applications particularly for anticancer research. Research approaches have been taken for the development of traditional medicinal products into effective, non-toxic and clinically proven pharmaceuticals. Plant-derived anticancer compounds might exert adverse toxic effects in humans, depending on the species of plant, drug administration route, dose regimens and drug receptiveness. Due to this possibility, it is important to assess the toxicity profiles of new potential anticancer compounds through proper toxicological tests. The importance of preclinical toxicology studies is continually drifting from the use of conventional methods to assess the impending adverse effects of new anticancer agents over the past 10 years. Recent practice encompasses designing and carrying out more personalized agent-directed research within the framework of clinical pharmacology guidelines. Distinctive standpoints have been brought into view by clinical application of anticancer drugs that are apparent in their discovery and development. Evolving standards in estimating novel drug candidates through clinical and preclinical trials manifest the cytotoxic compound enhancements over time, with substantial aid from circumstances, and the current interest in discovering drug candidates with specifications on reaching targeted cells. This chapter highlights the relevance of plant-derived anticancer compounds through their pharmacological and toxicological uses.

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Authors and Affiliations

  1. Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia

    Charles Gnanaraj

  2. Scigen Research and Innovation, Periyar Technology Business Incubator, Thanjavur, 613403, Tamil Nadu, India

    Charles Gnanaraj & Rengarajan Thamaraiselvan

  3. Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Sivapragasam Gothai, Katyakyini Muniandy & Palanisamy Arulselvan

  4. Muthayammal Centre for Advanced Research, Muthayammal College of Arts and Science, Rasipuram, Namakkal, Tamilnadu, India

    Palanisamy Arulselvan

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  1. Charles Gnanaraj
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  2. Sivapragasam Gothai
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  3. Katyakyini Muniandy
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  4. Rengarajan Thamaraiselvan
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Editors and Affiliations

  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Gnanaraj, C., Gothai, S., Muniandy, K., Thamaraiselvan, R., Arulselvan, P. (2017). Toxicological and Pharmacological Use of Anticancer Compounds. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Clinical Trials and Nanotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-8216-0_7

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