Skip to main content

Relevance of Traditional Unani (Greco-Arab) System of Medicine in Cancer: An Update

  • Chapter
  • First Online:
Anticancer Plants: Clinical Trials and Nanotechnology

Abstract

Cancer is one of the most dreadful diseases worldwide. The incidence of cancer has drastically increased in low- and middle-income countries and is a major cause of morbidity and mortality in the developed countries. Use of alternative medicines along with conventional ones against cancer managed the symptoms, control side effects, and improve the quality of life and mental state. Indian systems of medicine (ISM) including Unani (Greco-Arab medicine) have been used for healing and preventative health care all over the world since decades. Cancer (Arabic-Sartan) has been well described in Unani classical texts as a hard inflammation (Warm-e-Salabat) with lesion. The cancer management in Unani system includes regimenal therapy (Ilaj bi’l-Tadbir), dietotherapy (Ilaj bi’l-Ghidhā), pharmacotherapy (Ilāj bi’l-Dawā), and surgery (Ilāj bi’l-Yad). In pharmacotherapy, many Unani drugs have been evaluated preclinically (in vitro and in vivo studies) for its anticancer activities and found to be very effective, but unfortunately, no attention has been paid to explicate the efficacy of compound formulations of these Unani medicines in cancer management, till date. The aim of this chapter is to exploit and bring together the Unani system of medicine with conventional cancer therapies at interdisciplinary and integrative levels and also to discuss the future strategies for the prevention and management of cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • ACS-American Cancer Society (2014) Early history of cancer. https://www.cancer.org/ cancer/cancer-basics/history-of-cancer/cancer-causes-theories-throughout-history.html. Accessed on 17 Oct 2017

  • Aiello F, Armentano B, Polerà N, Carullo G, Loizzo MR, Bonesi M, Cappello MS, Capobianco L, Tundis R (2017) From vegetable waste to new agents for potential health applications: antioxidant properties and effects of extracts, fractions and pinocembrin from Glycyrrhiza glabra L. aerial parts on viability of five human cancer cell lines. J Agric Food Chem 65:7944–7954

    Article  CAS  PubMed  Google Scholar 

  • Alam A, Ahmed S, Alam T, Azeez A (2013) Cancer (Sartan) and its management in Unani (Greeco-Arab) medicine. Int J Pharm 1:612–630

    Google Scholar 

  • Alfaifi MY, Saleh KA, El-Boushnak MA, Elbehairi SE, Alshehri MA, Shati AA (2016) Antiproliferative activity of the methanolic extract of Withania somnifera leaves from Faifa mountains, Southwest Saudi Arabia, against several human cancer cell lines. Asian Pac J Cancer Prev 17:2723–2726

    PubMed  Google Scholar 

  • Al-Sheddi ES, Farshori NN, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA (2014) Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line. Asian Pac J Cancer Prev 15:983–987

    Article  PubMed  Google Scholar 

  • Anonymous (2016) Unani system of medicine, the science of health and healing. Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy (AYUSH), Government of India, New Delhi

    Google Scholar 

  • Anonymous (2017a) CCRUM. http://ccrum.res.in/UserView/index?mid=1480. Accessed on 22 Oct 2017

  • Anonymous (2017b) CCRUM. http://ccrum.res.in/ViewData/Multiple?mid=1596. Accessed on 22 Oct 2017

  • Anonymous (2017c) Biovoice news. http://www.biovoicenews.com/clinical-trials-to-determine-efficacy-of-traditional-medicine-for-cancer. Accessed on 22 Oct 10.2017

  • Asaduzzaman Khan M, Tania M, Fu S, Fu J (2017) Thymoquinone, as an anticancer molecule: from basic research to clinical investigation. Oncotarget 8:51907–51919

    PubMed  PubMed Central  Google Scholar 

  • Aslam M, Bano H, Vohora SB (1981) Sartan (cancer) and its treatment in Unani medicine. Am J Chin Med 9:95–107

    Article  CAS  PubMed  Google Scholar 

  • Avi Senna AH (1993) Al Kanoon Fi Altib (The rules of medicine). IzAldin Publications, Beirut

    Google Scholar 

  • Avi Senna AH (1037) Al Kanoon Fi Altib (The rules of medicine). Four volumes. Printed in 1993 by IzAldin Publications, Beirut (in Arabic)

    Google Scholar 

  • Azmi AK (2002) Sartan aur Tibb Unani: Moalijatee imkaanat ka ijmali jaayezha. Pandhra Rozah-Tibb-E-Mashriq: Delhi, Cancer Special Issue. New Public Press, Gali Kasimjaan, Delhi, India, pp 36–57

    Google Scholar 

  • Baghdadi IH (2004) Kitab Al-Mokhtarat fit Tibb (Urdu translation), vol-3 CCRUM. Ministry of Health and Family Welfare, Government of India, New Delhi, pp 90–128

    Google Scholar 

  • Balachandran C, Arun Y, Sangeetha B, Duraipandiyan V, Awale S, Emi N, Ignacimuthu S, Perumal PT (2017)In vitro and in vivo anticancer activity of 2-acetyl-benzylamine isolated from Adhatoda vasica L. leaves. Biomed Pharmacother 93:796–806

    Google Scholar 

  • Baliga MS, Thilakchand KR, Rai MP, Rao S, Venkatesh P (2012) Aegle marmelos (L.) Correa (Bael) and its phytochemicals in the treatment and prevention of cancer. Integr Cancer Ther 12:187–196

    Article  CAS  PubMed  Google Scholar 

  • Baradwaj RG, Rao MV, Senthil Kumar T (2017) Novel purification of 1′S-1′-acetoxychavicol acetate from Alpinia galanga and its cytotoxic plus antiproliferative activity in colorectal adenocarcinoma cell line SW480. Biomed Pharmacother 91:485–493

    Article  CAS  PubMed  Google Scholar 

  • Bartnik M, Sławińska-Brych A, Żurek A, Kandefer-Szerszeń M, Zdzisińska B (2017) 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. J Ethnopharmacol 207:19–29

    Article  CAS  PubMed  Google Scholar 

  • Baskar AA, A Numair KS, Alsaif MA, Ignacimuthu S (2012) In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer. Redox Rep 17:145–156

    Article  CAS  PubMed  Google Scholar 

  • Bogdanović V, Mrdjanović J, Borišev (2017) A review of the therapeutic antitumor potential of cannabinoids. J Altern Compl Med (Online). https://doi.org/10.1089/acm.2017.0016

  • Boon HS, Olatunde F, Zick SM (2007) Trends in complementary/alternative medicine use by breast cancer survivors: comparing survey data from 1998 and 2005. BMC Women’s Health 7:4. https://doi.org/10.1186/1472-6874-7-4

    Article  PubMed  PubMed Central  Google Scholar 

  • Caffarel MM, Andradas C, Pérez-Gómez E, Guzmán M, Sánchez C (2012) Cannabinoids, a new hope for breast cancer therapy. Cancer Treat Rev 38:911–918

    Article  CAS  PubMed  Google Scholar 

  • Calaf GM, Roy D (2017) Metastatic genes targeted by an antioxidant in an established radiation – and estrogen-breast cancer model. Int J Oncol 51:1590–1600

    Article  PubMed  Google Scholar 

  • Chaithongyot S, Asgar A, Senawong G, Yowapuy A, Lattmann E, Sattayasai N, Senawong T (2015) Anticancer effects of Curcuma C20-Dialdehyde against colon and cervical cancer cell lines. Asian Pac J Cancer Prev 16:6513–6519

    Article  PubMed  Google Scholar 

  • Chen X, Liu Z, Meng R, Shi C, Guo N (2017) Antioxidative and anticancer properties of Licochalcone A from licorice. J Ethnopharmacol 198:331–337

    Article  CAS  PubMed  Google Scholar 

  • Choedon T, Shukla SK, Kumar VJ (2010) Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. J Ethnopharmacol 129:208–213

    Article  PubMed  Google Scholar 

  • Conforti F, Ioele G, Statti GA, Marrelli M, Ragno G, Menichini F (2008) Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem Toxicol 46:3325–3332

    Article  CAS  PubMed  Google Scholar 

  • D’Souza ND, Murthy NS, Aras RY (2013) Projection of cancer incident cases for India-till 2026. Asian Pac J Cancer Prev 14:4379–4386

    Article  PubMed  Google Scholar 

  • Deng G, Cassileth B (2014) Integrative oncology: an overview. Am Soc Clin Oncol Educ Book:233–242

    Article  Google Scholar 

  • Diamandopoulos GT (1996) Cancer: an historical perspective. Anticancer Res 16:1595–1602

    PubMed  CAS  Google Scholar 

  • Dikshit R, Gupta PC, Ramasundarahettige C, Gajalakshmi V, Aleksandrowicz L, Badwe R, Kumar R, Roy S, Suraweera W, Bray F, Mallath M, Singh PK, Sinha DN, Shet AS, Gelband H, Jha P (2012) Cancer mortality in India: a nationally representative survey. Lancet 379:1807–1816

    Article  PubMed  Google Scholar 

  • Duraipandiyan V, Al-Dhabi NA, Balachandran C, Ignacimuthu S, Sankar C, Balakrishna K (2015) Antimicrobial, antioxidant, and cytotoxic properties of vasicine acetate synthesized from vasicine isolated from Adhatoda vasica L. Biomed Res Int 2015:727304. https://doi.org/10.1155/2015/727304

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ernst E (2009) Complementary and alternative medicine (CAM) and cancer: the kind face of complementary medicine. Int J Surg 7:499–500

    Article  CAS  PubMed  Google Scholar 

  • Esmaeilbeig M, Kouhpayeh SA, Amirghofran Z (2015) An investigation of the growth inhibitory capacity of several medicinal plants from Iran on tumor cell lines. Iran J Cancer Prev 8:e4032. https://doi.org/10.17795/ijcp-4032

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386

    Article  CAS  Google Scholar 

  • Gao Y, Huang R, Gong Y, Park HS, Wen Q, Almosnid NM, Chippada-Venkata UD, Hosain NA, Vick E, Farone A, Altman E (2015) The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells. Oncotarget 6:24304–24319

    PubMed  PubMed Central  Google Scholar 

  • Gordanian B, Behbahani M, Carapetian J, Fazilati M (2014) In vitro evaluation of cytotoxic activity of flower, leaf, stem and root extracts of five Artemisia species. Res Pharma Sci 9:91–96

    Google Scholar 

  • Gul MZ, Bhakshu LM, Ahmad F, Kondapi AK, Qureshi IA, Ghazi IA (2011) Evaluation of Abelmoschus moschatus extracts for antioxidant, free radical scavenging, antimicrobial and antiproliferative activities using in vitro assays. BMC Complement Altern Med 11:64. https://doi.org/10.1186/1472-6882-11-64

  • Gul MZ, Chandrasekaran SKM, Bhat MY, Maurya R, Qureshi IA, Ghazi IA (2016) Bioassay-guided fractionation and in vitro anti-proliferative effects of fractions of Artemisia nilagirica on THP-1 cell line. Nutr Cancer 68:1210–1224

    Article  PubMed  Google Scholar 

  • Gupta SC, Kim JH, Prasad S, Aggarwal BB (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 29:405–434

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gutheil WG, Reed G, Ray A, Anant S, Dhar A (2012) Crocetin: an agent derived from saffron for prevention and therapy for cancer. Curr Pharm Biotechnol 13:173–179

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Halder B, Singh S, Thakur SS (2015) Withania somnifera root extract has potent cytotoxic effect against human malignant melanoma cells. PLoS One 10:e0137498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hazra B, Sarkar R, Bhattacharyya S, Roy P (2002) Tumour inhibitory activity of chicory root extract against Ehrlich ascites carcinoma in mice. Fitoterapia 73:730–733

    Article  CAS  PubMed  Google Scholar 

  • Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M (2012) How many cancer patients use complementary and alternative medicine: a systematic review and meta analysis. Integr Cancer Ther 11:187–203

    Article  PubMed  Google Scholar 

  • Ibn AlBitar DAM (1874) AlJame Li-Mofradat al Adwiyah wal Aghthiyah (The collection of medical items and food). Two volumes. Dar Sader Publishing, Beirut (In Arabic)

    Google Scholar 

  • Ibn Qiff Maseehi YNM (1995) Kitab Al-Umda fi Al-Jaraha (Urdu Translation), vol 1. Central Council for Research in Unani Medicine (CCRUM), Ministry of Health and Family Welfare, Government of India, New Delhi, pp 174–175

    Google Scholar 

  • Ibn Rushd (1980) Kitab Al-Kulliyat (Urdu translation). 1st ed. Central Council for Research in Unani Medicine (CCRUM), Ministry of Health and Family Welfare, Government of India, New Delhi, pp 83–95

    Google Scholar 

  • Ibn Sina (1992) Al-Qanoon fit Tibb (Urdu translation by Gulam Husain Kanturi), vol-4. Nigarishat Miyan Chambers, Lahore, pp 175–176

    Google Scholar 

  • Jafari S, Saeidnia S, Hajimehdipoor H, Ardekani MR, Faramarzi MA, Hadjiakhoondi A, Khanavi M (2013) Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation. Daru 21:37. https://doi.org/10.1186/2008-2231-21-37

    Article  PubMed  PubMed Central  Google Scholar 

  • Jagetia GC, Baliga MS (2006) Evaluation of anticancer activity of the alkaloid fraction of Alstonia scholaris (Sapthaparna)in vitro andin vivo. Phytother Res 20:103–109

    Article  PubMed  Google Scholar 

  • Jagetia GC, Venkatesh P, Baliga MS (2005) Aegle marmelos (L.) Correa inhibits the proliferation of transplanted Ehrlich ascites carcinoma in mice. Biol Pharm Bull 28:58–64

    Article  CAS  PubMed  Google Scholar 

  • Jahan S, Chaudhary R, Goyal PK (2009) Anticancer activity of an Indian medicinal plant, Alstonia scholaris, on skin carcinogenesis in mice. Integr Cancer Ther 8:273–279

    Article  CAS  PubMed  Google Scholar 

  • Jia L (2012) Cancer complementary and alternative medicine research at the US National Cancer Institute. Chin J Integr Med 18:325–332

    Article  PubMed  Google Scholar 

  • John S, Sivakumar KC, Mishra R (2017) Bacoside-A induces tumor cell death in human glioblastoma cell lines through catastrophic macropinocytosis. Front Mol Neurosci 10:171. https://doi.org/10.3389/fnmol.2017.00171

    Article  PubMed  PubMed Central  Google Scholar 

  • Jurjani A (2010) Zakheera Khwarazm Shahi, vol 7. Idara Kitab AL-Shifa, New Delhi pp 30–32

    Google Scholar 

  • Kabiruddin (2006) Alkarabadeen, 2nd edn. CCRUM, Ministry of Health and Family Welfare, Government of India, New Delhi, pp 1093–1094

    Google Scholar 

  • Kalyani MI, Lingaraju SM, Salimath BP (2012) A pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary carcinoma cells. J Nat Med 67:123–136

    Article  CAS  PubMed  Google Scholar 

  • Kaur V, Kumar M, Kaur P, Kaur S, Kaur S (2017) Inhibitory activities of butanol fraction from Butea monosperma (Lam.) Taub. bark against free radicals, genotoxins and cancer cells. Chem Biodivers 14:e1600484. https://doi.org/10.1002/cbdv.201600484

    Article  CAS  Google Scholar 

  • Khan A (2006) Avicenna (Ibn Sina): Muslim physician and philosopher of the eleventh century (Great Muslim Philosophers and Scientists of the Middle Ages). The Rosen Publishing Group, New York

    Google Scholar 

  • Kim KB, Kim K, Bae S, Choi Y, Cha HJ, Kim SY, Lee JH, Jeon SH, Jung HJ, Ahn KJ, An IS, An S (2014) MicroRNA-1290 promotes asiatic acid-induced apoptosis by decreasing BCL2 protein level in A549 non-small cell lung carcinoma cells. Oncol Rep 32:1029–1036

    Article  CAS  PubMed  Google Scholar 

  • Kou B, Liu W, Zhao W, Duan P, Yang Y, Yi Q, Guo F, Li J, Zhou J, Kou Q (2017) Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-β/Smad2/3 signaling pathway. Oncol Rep (Online). https://doi.org/10.3892/or.2017.6012

  • Lampronti I, Martello D, Bianchi N, Borgatti M, Lambertini E, Piva R, Jabbar S, Choudhuri MS, Khan MT, Gambari R (2003) In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. Phytomedicine 10:300–308

    Article  CAS  PubMed  Google Scholar 

  • Lébri M, Tilaoui M, Bahi C, Achibat H, Akhramez S, Fofié YBN, Gnahoué G, Lagou SM, Zirihi GN, Coulibaly A, Zyad A, Hafid A, Khouili M (2015) Phytochemical analysis and in vitro anticancer effect of aqueous extract of Abrus precatorius L. Der Pharma Chemica 7:112–117

    Google Scholar 

  • Leelawat S, Leelawat K (2016) Molecular mechanisms of cholangiocarcinoma cell inhibition by medicinal plants. Oncol Lett 13:961–966

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li AX, Sun M, Li X (2017) Withaferin-A induces apoptosis in osteosarcoma U2OS cell line via generation of ROS and disruption of mitochondrial membrane potential. Eur Rev Med Pharmacol Sci 21:1368–1374

    PubMed  Google Scholar 

  • Majoosi AIA (2010) Kamil ul Sanaah (Urdu translation by Kantoori GH), vol 1. Idara Kitabus Shifa, New Delhi, pp 414–427

    Google Scholar 

  • Mallick MN, Akhtar MS, Najm MZ, Tamboli ET, Ahmad S, Husain SA (2015) Evaluation of anticancer potential of Bacopa monnieri L. against MCF-7 and MDA-MB 231 cell line. J Pharm Bioallied Sci 7:325–328

    PubMed  PubMed Central  CAS  Google Scholar 

  • Malvia S, Bagadi SA, Dubey US, Saxena S (2017) Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol 13:289–295

    Article  PubMed  Google Scholar 

  • McKenna MK, Gachuki BW, Alhakeem SS, Oben KN, Rangnekar VM, Gupta RC, Bondada S (2015) Anticancer activity of withaferin A in B-cell lymphoma. Cancer Biol Ther 16:1088–1098

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mirkin V, Berrebi A, Rakhman I, Haran M, Shvidel L (2017) The role of the plant Artemisia in survival and induction of apoptosis of b cells in Chronic Lymphocytic Leukemia (CLL). Harefuah 156:86–88

    PubMed  Google Scholar 

  • Mitra SK, Prakash NS, Sundaram R (2012) Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus. Indian J Pharm 44:732–736

    Article  Google Scholar 

  • Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N (2004) Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia 75:375–377

    Article  PubMed  Google Scholar 

  • More NV, Kharat AS (2016) Antifungal and anticancer potential of Argemone mexicana L. Medicines 3:28. https://doi.org/10.3390/medicines3040028

    Article  CAS  PubMed Central  Google Scholar 

  • Mostofa AGM, Hossain MK, Basak D, Bin Sayeed MS (2017) Thymoquinone as a potential adjuvant therapy for cancer treatment: evidence from preclinical studies. Front Pharmacol 8:295. https://doi.org/10.3389/fphar.2017.00295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murthy NS, Chaudhry K, Rath GK (2008) Burden of cancer and projections for 2016, Indian scenario: gaps in the availability of radiotherapy treatment facilities. Asian Pac J Cancer Prev 9:671–677

    PubMed  CAS  Google Scholar 

  • Nourazarian SM, Nourazarian A, Majidinia M, Roshaniasl E (2015) Effect of root extracts of medicinal herb Glycyrrhiza glabra on HSP90 gene expression and apoptosis in the HT-29 colon cancer cell line. Asian Pac J Cancer Prev 16:8563–8566

    Article  PubMed  Google Scholar 

  • Pan X, Matsumoto M, Nakamura Y, Kikuchi T, Zhang J, Ukiya M, Suzuki T, Koike K, Akihisa R, Akihisa T (2014) Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities. Chem Biodivers 11:987–1000

    Article  CAS  PubMed  Google Scholar 

  • Panneerselvam K, Lin SC, Liu CL, Liaw YC, Lin JY, Lu TH (2000) Crystallization of agglutinin from the seeds of Abrus precatorius. Acta Crystallogr D 56:898–899

    Article  CAS  PubMed  Google Scholar 

  • Pittella F, Dutra RC, Junior DD, Lopes MT, Barbosa NR (2009) Antioxidant and cytotoxic activities of Centella asiatica (L.) Urb. Int J Mol Sci 10:3713–3721

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • PIB-Press Information Bureau (2016) Government of India, AYUSH, Government has Launched Special Programmes for Control and Prevention of Lifestyle Diseases. http://pib.nic.in/newsite/PrintRelease.aspx?relid=154809. Accessed on 22. Oct 2017

    Google Scholar 

  • Qamari NBM (2008) Ghana Mina (Urdu translation), 1st ed. CCRUM, Ministry of Health and Family Welfare, Government of India, New Delhi, pp 508–510

    Google Scholar 

  • Quraeishi AH (2002) Cancer ya Sartan: ek Ta’ruf. Pandhra Rozah-Tibb-e-Mashriq, Cancer Special Issue. New Public Press, Delhi, p 72

    Google Scholar 

  • Rahamooz Haghighi S, Asadi MH, Akrami H, Baghizadeh A (2017) Anti-carcinogenic and anti-angiogenic properties of the extracts of Acorus calamus on gastric cancer cells. Avicenna J Phytomed 7:145–156

    PubMed  PubMed Central  Google Scholar 

  • Razi AMBZ (2002) Kitab Al-Havi (Urdu translation by CCRUM), vol 12. CCRUM, Ministry of Health and Family Welfare, Government of India, New Delhi, pp 9–24

    Google Scholar 

  • Ren L, Cao QX, Zhai FR, Yang SQ, Zhang HX (2016) Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling. Pharm Biol 54:2377–2382

    Article  CAS  PubMed  Google Scholar 

  • Rhazes (925) Al Hawy (The Comprehensive). Dar AlKalam Publishing Beirut (in Arabic)

    Google Scholar 

  • Riaz M, Bilal A, Ali MS, Fatima I, Faisal A, Sherkheli MA, Asghar A (2017) Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines. Nat Prod Res 31:583–587

    Article  CAS  PubMed  Google Scholar 

  • Saad B, Said O (2011) Greco-Arab and Islamic herbal medicine: traditional system, ethics, safety, efficacy, and regulatory issues. Wiley, USA

    Book  Google Scholar 

  • Saad B, Azaizeh H, Said O (2005) Tradition and perspectives of Arab herbal medicine: a review. Evid Based Compl Altern Med 2:475–479

    Article  Google Scholar 

  • Saad B, Azaizeh H, Said O (2008) Arab herbal medicine. Bot Med Clin Pract 4:31

    Article  Google Scholar 

  • Said O, Zaid H, Saad B (2011) Greco-Arab and Islamic herbal medicine and cancer treatment/prevention. In: Watson RR, Preedy RV (eds) Bioactive foods and extracts cancer treatment and prevention. CRC Press, Taylor and Francis, Boca Raton, pp 49–66

    Google Scholar 

  • Saleh AM, Aljada A, Rizvi SA, Nasr A, Alaskar AS, Williams JD (2014) In vitro cytotoxicity of Artemisia vulgaris L. essential oil is mediated by a mitochondria-dependent apoptosis in HL-60 leukemic cell line. BMC Complement Altern Med 14:226

    Article  PubMed  PubMed Central  Google Scholar 

  • Samarghandian S, Hadjzadeh MA, Afshari JT, Hosseini M (2014) Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line. BMC Complement Altern Med 14:192

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Samarqandi AN (2007a) Sharah-e-Asbaab Tarjumah Kabeer: vol- III and IV (Urdu translation by Hakim Kabiruddin). Ejaj Publishing House, Darya Ganj, New Delhi, pp 223–226

    Google Scholar 

  • Samarqandi AN (2007b) Sharah-e-AsbaabTarjumah Kabeer: vol-I (Urdu translation by HkmKabiruddin). Ejaj Publishing House, Darya Ganj, New Delhi

    Google Scholar 

  • Samarqandi AN (2010) Moalajat Sharh-e-Asbab (Urdu translation by Khuwaja Rizwan), vol-3. CCRUM, Ministry of Health and Family Welfare, Government of India, New Delhi, pp 369–370

    Google Scholar 

  • Shafi G, Hasan TN, Syed NA, Al-Hazzani AA, Alshatwi AA, Jyothi A, Munshi A (2012) Artemisia absinthium : a novel potential complementary and alternative medicine for breast cancer. Mol Biol Rep 39:7373–7379

    Article  CAS  PubMed  Google Scholar 

  • Shamsi Y, Rehman RU (2012) Concept of cancer in Greco-Roman and Islamic medicine. Int J Biol Sci 3:63–67

    Google Scholar 

  • Shamsi Y, Khan AA, Alam T, Jabeen A (2016) Management of cancer with Munzij and Mus′hil therapy: a regimen of Ilaj Bit Tadbeer (Regimenal therapy) in Unani system of medicine. Int J Curr Rev Res 8:4–9

    Google Scholar 

  • Singh R, Sharma J, Goyal PK (2014) Prophylactic role of Averrhoa carambola (Star Fruit) extract against chemically induced hepatocellular carcinoma in swiss albino mice. Adv Pharmacol Sci 2014:158936. https://doi.org/10.1155/2014/158936

    Article  PubMed  PubMed Central  Google Scholar 

  • Singh S, Verma M, Malhotra M, Prakash S, Singh TD (2015) Cytotoxicity of alkaloids isolated from Argemone mexicana on SW480 human colon cancer cell line. Pharm Biol 54:740–745

    Article  CAS  PubMed  Google Scholar 

  • Song NR, Lee E, Byun S, Kim JE, Mottamal M, Park JH, Lim SS, Bode AM, Lee HJ, Lee KW, Dong Z (2013) Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Cancer Prev Res 6:1293–1303

    Article  CAS  Google Scholar 

  • Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, Ramanujam RP, Balakrishnan A, Vishwakarma RA, Anant S (2008) Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos. Cancer Res 68:8573–8581

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Subramaniyan B, Kumar V, Mathan G (2017) Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. Biomed Pharmacother 90:402–413

    Article  CAS  PubMed  Google Scholar 

  • Suresh V, Sruthi V, Padmaja B, Asha VV (2011) In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb. J Ethnopharmacol 134:872–877

    Article  CAS  PubMed  Google Scholar 

  • Tabri AAM (1995) Moalijat-e-Buqratia, vol 2. CCRUM, Ministry of Health and Family Welfare, Govt of India, New Delhi, pp 244–248

    Google Scholar 

  • Tabri AAM (1997) Moalijat-e-Buqratia (Urdu translation) vol 2, CCRUM, Ministry of Health and Family Welfare, Govt of India, New Delhi

    Google Scholar 

  • Tabri R (2010) Firdousul Hikmat, Idarae Kitabushifa, New Delhi

    Google Scholar 

  • Velasco G, Sánchez C, Guzmán M (2016) Anticancer mechanisms of cannabinoids. Rev Curr Oncol 23:S23–S32

    Article  CAS  Google Scholar 

  • Verma SP, Tripathi VC, Das P (2014) Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death. Asian Pac J Cancer Prev 15:1937–1941

    Article  PubMed  Google Scholar 

  • World Cancer Report (2014) In: Stewart BW, Wild CP (eds) International Agency for Research on Cancer. World Health Organization (WHO), Lyon Cedex

    Google Scholar 

  • World Health Organization (2013) World traditional medicine strategy (2014–2023). WHO Press, World Health Organization, Geneva

    Google Scholar 

  • Yoder LH (2005) Let’s talk cancer prevention. Med Surg Nursing 14:195–198

    Google Scholar 

  • Yook JS, Kim M, Pichiah PB, Jung SJ, Chae SW, Cha YS (2015) The antioxidant properties and inhibitory effects on HepG2 cells of chicory cultivated using three different kinds of fertilizers in the absence and presence of pesticides. Molecules 20:12061–12075

    Article  CAS  PubMed  Google Scholar 

  • Zhou X, Su J, Feng S, Wang L, Yin X, Yan J, Wang Z (2016) Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells. Onco Target 7:79076–79088

    Google Scholar 

Download references

Acknowledgment

MK Husain is thankful to Central Council for Research in Unani Medicine (CCRUM), Ministry of AYUSH, Government of India, for the Young Scientist Award, 2017. The opinions expressed in this article are the author’s own and do not reflect the view of either CCRUM or CRIUM.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Husain, M.K., Khalid, M., Penchala Pratap, G., Kazmi, M.H. (2017). Relevance of Traditional Unani (Greco-Arab) System of Medicine in Cancer: An Update. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Clinical Trials and Nanotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-8216-0_10

Download citation

Publish with us

Policies and ethics