Abstract
Creatinine is a waste product derived from dehydration of creatine and is excreted by the kidneys. It is synthesized in the kidneys, liver, and pancreas from three amino acids –arginine, glycine, and methionine – by two enzyme-mediated reactions. After synthesis, creatine is transported in the blood to other organs such as the muscle and brain and phosphorylated to phosphocreatine which is a high-energy compound. Some of the free creatine in the muscle is spontaneously converted to creatinine (anhydride of creatine). Creatine and creatine phosphate constitute about 400 mg/100 mg of fresh muscle. Both compounds are converted spontaneously to creatinine at rate of 1–2%.
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Kumar, V., Gill, K.D. (2018). To Estimate Creatinine Level in Serum and Urine by Jaffe’s Reaction. In: Basic Concepts in Clinical Biochemistry: A Practical Guide. Springer, Singapore. https://doi.org/10.1007/978-981-10-8186-6_18
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DOI: https://doi.org/10.1007/978-981-10-8186-6_18
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Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8185-9
Online ISBN: 978-981-10-8186-6
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