Skip to main content

Dioscin

  • Chapter
  • First Online:
Natural Small Molecule Drugs from Plants
  • 162 Accesses

Abstract

Dioscin is extracted from Dioscorea nipponica Thunb. It has therapeutic effects on reducing blood lipids and protecting the liver, as well as antivirus, anti-inflammatory, and antitumor effects. It can be orally used to treat joint pain, arthritis, malaria, and chronic bronchitis. In addition, it is used externally to treat sore carbuncle swollen. Dioscin is an important predecessor for synthesizing steroid hormones. In China, dioscin tablets have already been used to treat hyperlipidemia in the clinical practice. With the ongoing efforts of evaluating the biological activity, dioscin has a great potential to be fully investigated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Tsukamoto T, Kawasaki T, Yamauchi T. Saponins of Japanese Dioscoreaceae. V. On the structure of dioscin. Pharm Bull. 1956;4(1):35–42.

    Article  CAS  Google Scholar 

  2. Yue L, et al. Recent advances of diosgenin in its pharmacologic activities and mechanism. Chin J Clin Pharm Ther. 2010;2:233–7.

    Google Scholar 

  3. Man S, et al. Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia. 2010;81(7):703–14.

    Article  CAS  Google Scholar 

  4. Zhao X, et al. Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo. Toxicol Lett. 2012;214(1):69–80.

    Article  CAS  Google Scholar 

  5. Kamisako T, Ogawa H. Regulation of biliary cholesterol secretion is associated with abcg5 and abcg8 expressions in the rats: effects of diosgenin and ethinyl estradiol. Hepatol Res. 2003;26(4):348–52.

    Article  CAS  Google Scholar 

  6. Xu LN, Wei YL, Peng JY. Advances in study of dioscin – a natural product. Zhongguo Zhong Yao Za Zhi. 2015;40(1):36–41.

    CAS  PubMed  Google Scholar 

  7. Qi M, et al. Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70. Pharmacol Res. 2015;100:341–52.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guan-Hua Du .

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Li, W., Du, GH. (2018). Dioscin. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_9

Download citation

Publish with us

Policies and ethics