Abstract
Dioscin is extracted from Dioscorea nipponica Thunb. It has therapeutic effects on reducing blood lipids and protecting the liver, as well as antivirus, anti-inflammatory, and antitumor effects. It can be orally used to treat joint pain, arthritis, malaria, and chronic bronchitis. In addition, it is used externally to treat sore carbuncle swollen. Dioscin is an important predecessor for synthesizing steroid hormones. In China, dioscin tablets have already been used to treat hyperlipidemia in the clinical practice. With the ongoing efforts of evaluating the biological activity, dioscin has a great potential to be fully investigated.
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References
Tsukamoto T, Kawasaki T, Yamauchi T. Saponins of Japanese Dioscoreaceae. V. On the structure of dioscin. Pharm Bull. 1956;4(1):35–42.
Yue L, et al. Recent advances of diosgenin in its pharmacologic activities and mechanism. Chin J Clin Pharm Ther. 2010;2:233–7.
Man S, et al. Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia. 2010;81(7):703–14.
Zhao X, et al. Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo. Toxicol Lett. 2012;214(1):69–80.
Kamisako T, Ogawa H. Regulation of biliary cholesterol secretion is associated with abcg5 and abcg8 expressions in the rats: effects of diosgenin and ethinyl estradiol. Hepatol Res. 2003;26(4):348–52.
Xu LN, Wei YL, Peng JY. Advances in study of dioscin – a natural product. Zhongguo Zhong Yao Za Zhi. 2015;40(1):36–41.
Qi M, et al. Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70. Pharmacol Res. 2015;100:341–52.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Li, W., Du, GH. (2018). Dioscin. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_9
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DOI: https://doi.org/10.1007/978-981-10-8022-7_9
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