Abstract
Huperzine A is obtained from Huperzia serrata, which is a highly effective and selective reversible inhibitor of acetylcholinesterase. It shows ability to improve learning and memory and was approved for treatment in Alzheimer’s disease (AD) in China in 1996. The low efficiency (only about six ten thousandths) of extraction of huperzine A from Huperzia serrata and the complexity of the full synthesis and structure modification of huperzine A limit its large-scale development and utilization. ZT-1, a derivative of huperzine A, was found to be with similar AChE inhibitory activity and lower butyrylcholinesterase inhibitory activity and toxicity compared with huperzine A. It can go through the blood-brain barrier, and its oral bioavailability and duration of action are comparable with huperzine A. ZT-1 is a promising anti-AD drug and has approved patents in China, America, Japan, and Europe.
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References
Jiangsu New Medical College. Great dictionary of Chinese medicine. Shang Hai: Shanghai Science and Technology Press; 1986.
Liu J, Yu C, Zhou Y, et al. Chemical studies on Huperzine A and Huperzine B. J Chem. 1986;44(10):1035–40.
Xu Z, Chu B, Luan X, et al. Structural determination of Fuding. Med J Chin People’s Liberation Army. 1985;10(4):263–4.4.
Tang XC. Huperzine A shuangyipian: a promising drug for Alzheimer’s disease. Zhongguo Yao Li Xue Bao. 1996;17(6):481–4.
Ma X, Gang DR. The lycopodium alkaloids. Nat Prod Rep. 2004;21(6):752–72.
Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a nature cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006;27(1):1–26.
Raves ML, Harel M, Pang YP, et al. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (−)-huperzine A. Nat Struct Biol. 1997;4(1):57–63.
Ma X, Tan C, Zhu D, et al. Huperzine A from Huperzia species–an ethnopharmacolgical review. J Ethnopharmacol. 2007;113(1):15–34.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Lian, WW., Liu, AL., Du, GH. (2018). Huperzine A. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_45
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DOI: https://doi.org/10.1007/978-981-10-8022-7_45
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