Abstract
Eserine is an alkaloid extracted from Physostigma venenosum, which is a reversible acetylcholinesterase (AChE) inhibitor. Eserine is the same as acetylcholine, which can combine with cholinesterase, while AChE inhibitor will combine more tightly with cholinesterase, which leads to slow hydrolysis, inactive enzyme, cumulative ACh, and emergent biological activities. Eserine is employed clinically to treat glaucoma. Compared with pilocarpine, it is provided with shorter effective time and stronger effect; meanwhile it is more provocative and poorly tolerated, so it is most often used to locally treat acute glaucoma. For eserine is toxic, unstable, and unsafe, it is only used early in ophthalmology. With the expansion of its applications and the development of analytic techniques, researchers got over some barriers, and the studies about eserine were taken more seriously in recent years.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
QE JI. Progress on mechanism and supersession of physostigmine. Foreign Med Sci Sect Pharm. 1993;20(4):201–3.
Zhou YY. Review of the synthesis of physostigmine. J Yunnan National Univ. 2015;24(3):165–75.
Proudfoot A. The early toxicology of physostigmine. Toxicol Rev. 2006;25(2):99–138.
Run GY. The development history of natural medicine transform to chemical medicine. Heilongjiang: Heilongjiang University of Chinese Medicine; 2013.
Yang SJ. Pharmacology. Beijing: People’s Medical Publishing House; 2012.
Boyer AW, Somani SM. Pharmacokinetics of biliary excretion of physostigmine in rat. Arch Int Pharmacodyn Ther. 1986;278(2):180–92.
Walter K, Muller M, Barkworth MF, et al. Pharmacokinetics of physostigmine in man following a single application of a transdermal system. Br J Clin Pharmacol. 1995;39(1):59–63.
Meuret P, Backman SB, Bonhomme V, et al. Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers. Anesthesiology. 2000;93(3):708–17.
Kirrane RM, Mitropoulou V, Nunn M, et al. Physostigmine and cognition in schizotypal personality disorder. Schizophr Res. 2001;48(1):1–5.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
About this chapter
Cite this chapter
Lin, YH., Fang, LH., Du, GH. (2018). Eserine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_41
Download citation
DOI: https://doi.org/10.1007/978-981-10-8022-7_41
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8021-0
Online ISBN: 978-981-10-8022-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)