Histeresis Loops and Yield Stress in Cell Research

  • Yong-de Shi


In the past, hysteresis loop and yield stress techniques were rarely used for research in biology and medicine. This article introduces the basic requirements, theoretical classification, and examples of hysteresis loop and yield stress investigations in cell research, biology and medicine (human blood system, human ejaculation system, and plant cells). Experiments are all based on very small forces. In summary, this article points out that hysteresis loop and yield stress techniques may be seen as supplemental tools to show structural change, when biomaterials are subject to mechanical shear action as a result of applied shear field forces.


Hysteresis loops Yield stress Whole blood Human ejaculate Mimosa pudica Ischemic stroke Structural change 



We thank Prof. Zhi-jiu Qin, Prof. Zhen-sheng Tang, and Prof. Chuan-zhen Lv for their co-investigation on the research grant entitled “Studies on hemorheology of cerebral vascular diseases”, received from the Central Health Ministry in 1990. For work on the instrument, we thank Senior Engineer Prof. Shu-kui Jiao, who designed the HT Rheometer for us to test the samples. The instrument belongs to the Shanghai 9th Hospital, administrated by Prof. Jing-wen Yang and Prof. Zhong-qing Le, who both helped us to execute the measurements. Blood samples were obtained of patients of the emergency Departments of the Huashan and Zhongshan Hospitals.

We thank Dr. Luan-feng Pan (Fudan University), Dr. Fei-kun Yang, and Dr. Si-qi Wang.

Last not least we thank Dr. Luan-feng Pan (Fudan University), and Dr. Fei-kun Yang for their cooperation.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Shanghai Medical CollegeFudan UniversityShanghaiChina

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