Abstract
Tumor development and progression correlate with the ability of the tumor to induce vascular development in the microenvironment. The nutritional supply is limited at the avascular stage, and the tumor remains in a state of dormancy or growth inertia; tumor cell apoptosis and proliferation maintain a dynamic balance. Angiogenic switch activation and subsequent angiogenesis are critical biological events that signal the initiation of tumor progression as dormancy ends. Besides the perfusion of nutrition to the tumor, neovessels have the paracrine function via endothelial cells and secrete various growth factors to stimulate vascular proliferation and accelerate tumor differentiation and invasion. Angiogenesis improves blood supply to the tumor and reflects a change in biological behavior: specifically, a transition from a dormant status to an active one or from low-grade malignancy to intermediate- or high-grade malignancy. Hence, the early detection and scrutiny of novel vessels related to tumors are vital for the assessment of disease progression and making decisions about proper medical intervention. In this chapter, tumor dormancy, angiogenic switch, angiogenesis, and the characterization of neovasculature will be discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Chapman AD, Kerr KM. The association between atypical adenomatous hyperplasia and primary lung cancer. Br J Cancer. 2000;83(5):632–6. https://doi.org/10.1054/bjoc.2000.1317.
de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, Yates L, Jamal-Hanjani M, Shafi S, Murugaesu N, Rowan AJ, Gronroos E, Muhammad MA, Horswell S, Gerlinger M, Varela I, Jones D, Marshall J, Voet T, Van Loo P, Rassl DM, Rintoul RC, Janes SM, Lee SM, Forster M, Ahmad T, Lawrence D, Falzon M, Capitanio A, Harkins TT, Lee CC, Tom W, Teefe E, Chen SC, Begum S, Rabinowitz A, Phillimore B, Spencer-Dene B, Stamp G, Szallasi Z, Matthews N, Stewart A, Campbell P, Swanton C. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science. 2014;346(6206):251–6. https://doi.org/10.1126/science.1253462.
Akslen LA, Naumov GN. Tumor dormancy—from basic mechanisms to clinical practice. APMIS. 2008;116(7–8):545–7. https://doi.org/10.1111/j.1600-0463.2008.01209.x.
Demicheli R. Tumour dormancy: findings and hypotheses from clinical research on breast cancer. Semin Cancer Biol. 2001;11(4):297–306. https://doi.org/10.1006/scbi.2001.0385.
Naumov GN, Folkman J, Straume O, Akslen LA. Tumor-vascular interactions and tumor dormancy. APMIS. 2008;116(7–8):569–85. https://doi.org/10.1111/j.1600-0463.2008.01213.x.
Naumov GN, Akslen LA, Folkman J. Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle. 2006;5(16):1779–87. https://doi.org/10.4161/cc.5.16.3018.
Folkman J. Proceedings: Tumor angiogenesis factor. Cancer Res. 1974;34(8):2109–13.
Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J. Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst. 1973;50(1):219–28.
Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955;9(4):539–49.
Weis SM, Cheresh DA. A wake-up call for hibernating tumour cells. Nat Cell Biol. 2013;15(7):721–3. https://doi.org/10.1038/ncb2794.
Moserle L, Amadori A, Indraccolo S. The angiogenic switch: implications in the regulation of tumor dormancy. Curr Mol Med. 2009;9(8):935–41.
Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407(6801):249–57. https://doi.org/10.1038/35025220.
Indraccolo S, Favaro E, Amadori A. Dormant tumors awaken by a short-term angiogenic burst: the spike hypothesis. Cell Cycle. 2006;5(16):1751–5. https://doi.org/10.4161/cc.5.16.2985.
Gilead A, Neeman M. Dynamic remodeling of the vascular bed precedes tumor growth: MLS ovarian carcinoma spheroids implanted in nude mice. Neoplasia. 1999;1(3):226–30.
Giaccia AJ. Hypoxic stress proteins: survival of the fittest. Semin Radiat Oncol. 1996;6(1):46–58. https://doi.org/10.1053/srao0060046.
Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res. 2007;67(6):2729–35. https://doi.org/10.1158/0008-5472.can-06-4102.
Gao F, Li M, Ge X, Zheng X, Ren Q, Chen Y, Lv F, Hua Y. Multi-detector spiral CT study of the relationships between pulmonary ground-glass nodules and blood vessels. Eur Radiol. 2013;23(12):3271–7. https://doi.org/10.1007/s00330-013-2954-3.
Suggested Readings
Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007;7(11):834–46. https://doi.org/10.1038/nrc2256.
Aoki T, Tomoda Y, Watanabe H, Nakata H, Kasai T, Hashimoto H, Kodate M, Osaki T, Yasumoto K. Peripheral lung adenocarcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival. Radiology. 2001;220(3):803–9. https://doi.org/10.1148/radiol.2203001701.
Fridman WH, Dieu-Nosjean MC, Pages F, Cremer I, Damotte D, Sautes-Fridman C, Galon J. The immune microenvironment of human tumors: general significance and clinical impact. Cancer Microenviron. 2013;6(2):117–22. https://doi.org/10.1007/s12307-012-0124-9.
Henschke CI, Yankelevitz DF, Mirtcheva R, McGuinness G, McCauley D, Miettinen OS. CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. AJR Am J Roentgenol. 2002;178(5):1053–7. https://doi.org/10.2214/ajr.178.5.1781053.
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307(5706):58–62. https://doi.org/10.1126/science.1104819.
Kakinuma R, Ohmatsu H, Kaneko M, Eguchi K, Naruke T, Nagai K, Nishiwaki Y, Suzuki A, Moriyama N. Detection failures in spiral CT screening for lung cancer: analysis of CT findings. Radiology. 1999;212(1):61–6. https://doi.org/10.1148/radiology.212.1.r99jn1461.
Kim HY, Shim YM, Lee KS, Han J, Yi CA, Kim YK. Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. Radiology. 2007;245(1):267–75. https://doi.org/10.1148/radiol.2451061682.
Knighton D, Ausprunk D, Tapper D, Folkman J. Avascular and vascular phases of tumour growth in the chick embryo. Br J Cancer. 1977;35(3):347–56.
Lee HJ, Goo JM, Lee CH, Yoo CG, Kim YT, Im JG. Nodular ground-glass opacities on thin-section CT: size change during follow-up and pathological results. Korean J Radiol. 2007;8(1):22–31. https://doi.org/10.3348/kjr.2007.8.1.22.
Mori K, Saitou Y, Tominaga K, Yokoi K, Miyazawa N, Okuyama A, Sasagawa M. Small nodular lesions in the lung periphery: new approach to diagnosis with CT. Radiology. 1990;177(3):843–9. https://doi.org/10.1148/radiology.177.3.2243999.
Noguchi M, Morikawa A, Kawasaki M, Matsuno Y, Yamada T, Hirohashi S, Kondo H, Shimosato Y. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer. 1995;75(12):2844–52.
Soda H, Nakamura Y, Nakatomi K, Tomonaga N, Yamaguchi H, Nakano H, Nagashima S, Anami M, Hayashi T, Tsukamoto K, Kohno S. Stepwise progression from ground-glass opacity towards invasive adenocarcinoma: long-term follow-up of radiological findings. Lung Cancer. 2008;60(2):298–301. https://doi.org/10.1016/j.lungcan.2007.09.001.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma. J Thorac Oncol. 2011;6(2):244–85. https://doi.org/10.1097/JTO.0b013e318206a221.
Udagawa T, Fernandez A, Achilles EG, Folkman J, D'Amato RJ. Persistence of microscopic human cancers in mice: alterations in the angiogenic balance accompanies loss of tumor dormancy. FASEB J. 2002;16(11):1361–70. https://doi.org/10.1096/fj.01-0813com.
Uhr JW, Marches R. Dormancy in a model of murine B cell lymphoma. Semin Cancer Biol. 2001;11(4):277–83. https://doi.org/10.1006/scbi.2001.0383.
Yang Z, Sone S, Takashima S, Li F, Honda T, Yamanda T. Small peripheral carcinomas of the lung: thin-section CT and pathologic correlation. Eur Radiol. 1999;9(9):1819–25.
Zhang L, Yankelevitz DF, Carter D, Henschke CI, Yip R, Reeves AP. Internal growth of nonsolid lung nodules: radiologic-pathologic correlation. Radiology. 2012;263(1):279–86. https://doi.org/10.1148/radiol.11101372.
Zwirewich CV, Vedal S, Miller RR, Muller NL. Solitary pulmonary nodule: high-resolution CT and radiologic-pathologic correlation. Radiology. 1991;179(2):469–76. https://doi.org/10.1148/radiology.179.2.2014294.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd. and People's Military Medical Press
About this chapter
Cite this chapter
Zheng, X., Li, M., Zhang, G. (2018). Tumor Dormancy and Angiogenesis-Dependent Progression. In: Zheng, X., Li, M., Zhang, G. (eds) Early-stage Lung Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-10-7596-4_5
Download citation
DOI: https://doi.org/10.1007/978-981-10-7596-4_5
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-7595-7
Online ISBN: 978-981-10-7596-4
eBook Packages: MedicineMedicine (R0)