Abstract
A numerical method for massively parallel computing to solve fluid-structure interaction problems was developed and the method was employed for solving the multiscale problems in biomedical applications. As one of the examples, a platelet adhesion process to the vessel wall, which occurs at the initial stage of a thrombosis, was analyzed using the multiscale method of coupling continuum scale finite difference method with the molecular scale Monte Carlo method. The platelets adhesion to the injured vessel wall is caused by the protein-protein binding (GP1b-α on the platelet—VWF on the wall.). This protein-protein binding force is evaluated by Monte Carlo simulation, solving the stochastic process of each biding. Adhered platelets also feel the fluid mechanical force from blood flow and this force is affected by the presence of red blood cells, which causes the drastic change to the adhesion process. As another example of multiscale simulations, ultrasound therapy method using microbubbles are also explained.
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Takagi, S., Shimizu, K., Ii, S., Sugiyama, K., Okita, K. (2019). Multiscale Simulations for Fluid Structure Interaction Problems with Biomedical Applications. In: Zhou, Y., Kimura, M., Peng, G., Lucey, A., Huang, L. (eds) Fluid-Structure-Sound Interactions and Control. FSSIC 2017. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-10-7542-1_31
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DOI: https://doi.org/10.1007/978-981-10-7542-1_31
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