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Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking andOther Addictions

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Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment

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Abstract

Both nicotine and alcohol addictions are severe public health hazards worldwide. Various twin and family studies have demonstrated that genetic factors contribute to vulnerability to these addictions; however, the susceptibility genes and the variants underlying them remain largely unknown. Of the susceptibility genes investigated, DRD2 has received much attention. Considering new evidence supporting the association of DRD2 and its adjacent gene ANKK1 with various addictions, in this chapter, we provide an updated view of the involvement of variants in DRD2 and ANKK1 in the etiology of nicotine dependence (ND) and alcohol dependence (AD) based on linkage, association, and molecular studies. These findings show that both genes are significantly associated with addictions, with the association with ANKK1 appearing to be stronger than that with DRD2. More replication studies in independent samples and functional studies of some of these variants are warranted.

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References

  • Agrawal A, Edenberg HJ, Foroud T, Bierut LJ, Dunne G, Hinrichs AL, Nurnberger JI, Crowe R, Kuperman S, Schuckit MA, Begleiter H, Porjesz B, Dick DM (2006) Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet 36:640–650. https://doi.org/10.1007/s10519-006-9069-4

    Article  PubMed  Google Scholar 

  • Al-Eitan LN, Jaradat SA, Hulse GK, Tay GK (2012) Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent. BMC Res Notes 5:497. https://doi.org/10.1186/1756-0500-5-497

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Amadeo S, Abbar M, Fourcade ML, Waksman G, Leroux MG, Madec A, Selin M, Champiat JC, Brethome A, Leclaire Y et al (1993) D2 dopamine receptor gene and alcoholism. J Psychiatr Res 27:173–179

    Article  CAS  PubMed  Google Scholar 

  • Anghelescu I, Germeyer S, Muller MJ, Klawe C, Singer P, Dahmen N, Wetzel H, Himmerich H, Szegedi A (2001) No association between the dopamine d2 receptor taqi a1 allele and earlier age of onset of alcohol dependence according to different specified criteria. Alcohol Clin Exp Res 25:805–809

    Article  CAS  PubMed  Google Scholar 

  • Arinami T, Gao M, Hamaguchi H, Toru M (1997) A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6:577–582

    Article  CAS  PubMed  Google Scholar 

  • Berggren U, Fahlke C, Aronsson E, Karanti A, Eriksson M, Blennow K, Thelle D, Zetterberg H, Balldin J (2006) The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is small. Alcohol Alcohol 41:479–485. https://doi.org/10.1093/alcalc/agl043

    Article  CAS  PubMed  Google Scholar 

  • Berlin I, Covey LS, Jiang H, Hamer D (2005) Lack of effect of D2 dopamine receptor TaqI A polymorphism on smoking cessation. Nicotine Tob Res 7:725–728. https://doi.org/10.1080/14622200500259176

    Article  CAS  PubMed  Google Scholar 

  • Bertolino A, Fazio L, Caforio G, Blasi G, Rampino A, Romano R, Di Giorgio A, Taurisano P, Papp A, Pinsonneault J, Wang D, Nardini M, Popolizio T, Sadee W (2009) Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia. Brain 132:417–425. https://doi.org/10.1093/brain/awn248

    Article  PubMed  Google Scholar 

  • Betcheva ET, Mushiroda T, Takahashi A, Kubo M, Karachanak SK, Zaharieva IT, Vazharova RV, Dimova II, Milanova VK, Tolev T, Kirov G, Owen MJ, O’Donovan MC, Kamatani N, Nakamura Y, Toncheva DI (2009) Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet 54:98–107. https://doi.org/10.1038/jhg.2008.14

    Article  CAS  PubMed  Google Scholar 

  • Bien TH, Burge R (1990) Smoking and drinking: a review of the literature. Int J Addict 25:1429–1454

    Article  CAS  PubMed  Google Scholar 

  • Bierut LJ, Rice JP, Goate A, Hinrichs AL, Saccone NL, Foroud T, Edenberg HJ, Cloninger CR, Begleiter H, Conneally PM, Crowe RR, Hesselbrock V, Li T-K, Nurngerger JI, Porjesz B, Schuckit MA, Reich T (2004) A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. Am J Med Genet 124:19–27

    Article  Google Scholar 

  • Blasi G, Lo Bianco L, Taurisano P, Gelao B, Romano R, Fazio L, Papazacharias A, Di Giorgio A, Caforio G, Rampino A, Masellis R, Papp A, Ursini G, Sinibaldi L, Popolizio T, Sadee W, Bertolino A (2009) Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. J Neurosci 29:14812–14819. https://doi.org/10.1523/JNEUROSCI.3609-09.2009

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blasi G, Napolitano F, Ursini G, Taurisano P, Romano R, Caforio G, Fazio L, Gelao B, Di Giorgio A, Iacovelli L, Sinibaldi L, Popolizio T, Usiello A, Bertolino A (2011) DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia. Proc Natl Acad Sci U S A 108:1158–1163. https://doi.org/10.1073/pnas.1013535108

    Article  CAS  PubMed  Google Scholar 

  • Blomqvist O, Ericson M, Engel JA, Soderpalm B (1997) Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine. Eur J Pharmacol 334:149–156

    Article  CAS  PubMed  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055–2060

    Article  CAS  PubMed  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Ozkaragoz T, Fitch RJ, Wood R, Finley O, Sadlack F (1993) Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics. Alcohol 10:59–67

    Article  CAS  PubMed  Google Scholar 

  • Bontempi S, Fiorentini C, Busi C, Guerra N, Spano P, Missale C (2007) Identification and characterization of two nuclear factor-kappaB sites in the regulatory region of the dopamine D2 receptor. Endocrinology 148:2563–2570. https://doi.org/10.1210/en.2006-1618

    Article  CAS  PubMed  Google Scholar 

  • Breen G, Brown J, Maude S, Fox H, Collier D, Li T, Arranz M, Shaw D, StClair D (1999) -141 C del/ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. Am J Med Genet 88:407–410

    Article  CAS  PubMed  Google Scholar 

  • Breslau N (1995) Psychiatric comorbidity of smoking and nicotine dependence. Behav Genet 25:95–101

    Article  CAS  PubMed  Google Scholar 

  • Carpenter MJ, Upadhyaya HP, LaRowe SD, Saladin ME, Brady KT (2006) Menstrual cycle phase effects on nicotine withdrawal and cigarette craving: a review. Nicotine Tob Res 8:627–638. https://doi.org/10.1080/14622200600910793

    Article  CAS  PubMed  Google Scholar 

  • Chen CH, Chien SH, Hwu HG (1996) Lack of association between TaqI A1 allele of dopamine D2 receptor gene and alcohol-use disorders in atayal natives of Taiwan. Am J Med Genet 67:488–490. https://doi.org/10.1002/(SICI)1096-8628(19960920)67:5<488::AID-AJMG10>3.0.CO;2-J

    Article  CAS  PubMed  Google Scholar 

  • Chien YL, Hwu HG, Fann CS, Chang CC, Tsuang MT, Liu CM (2013) DRD2 haplotype associated with negative symptoms and sustained attention deficits in Han Chinese with schizophrenia in Taiwan. J Hum Genet 58:229–232. https://doi.org/10.1038/jhg.2012.157

    Article  CAS  PubMed  Google Scholar 

  • Cinciripini P, Wetter D, Tomlinson G, Tsoh J, De Moor C, Cinciripini L, Minna J (2004) The effects of the DRD2 polymorphism on smoking cessation and negative affect: evidence for a pharmacogenetic effect on mood. Nicotine Tob Res 6:229–239. https://doi.org/10.1080/14622200410001676396

    Article  CAS  PubMed  Google Scholar 

  • Clarke T-K, Weiss ARD, Ferarro TN, Kampman KM, Dackis CA, Pettinati HM, O’brien CP, Oslin DW, Lohoff FW, Berrettini WH (2013) The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction. Ann Hum Genet. https://doi.org/10.1111/ahg.12046

  • Collins AC (1990) Interactions of ethanol and nicotine at the receptor level. Recent Dev Alcohol 8:221–231

    CAS  PubMed  Google Scholar 

  • Colzato LS, van den Wildenberg WP, Van der Does AJ, Hommel B (2010) Genetic markers of striatal dopamine predict individual differences in dysfunctional, but not functional impulsivity. Neuroscience 170:782–788. https://doi.org/10.1016/j.neuroscience.2010.07.050

    Article  CAS  PubMed  Google Scholar 

  • Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, Knell E, Kocsis P, Baumgarten R, Kovacs BW et al (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 266:1793–1800

    Article  CAS  PubMed  Google Scholar 

  • Comings DE, Ferry L, Bradshaw-Robinson S, Burchette R, Chiu C, Muhleman D (1996a) The dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking. Pharmacogenetics 6:73–79

    Article  CAS  PubMed  Google Scholar 

  • Comings DE, Muhleman D, Gysin R (1996b) Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication. Biol Psychiatry 40:368–372. https://doi.org/10.1016/0006-3223(95)00519-6

    Article  CAS  PubMed  Google Scholar 

  • Comings DE, Wu S, Chiu C, Ring RH, Gade R, Ahn C, MacMurray JP, Dietz G, Muhleman D (1996c) Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes – DRD2, D beta H, and DAT1. Am J Med Genet 67:264–288. https://doi.org/10.1002/(SICI)1096-8628(19960531)67:3<264::AID-AJMG4>3.0.CO;2-N

    Article  CAS  PubMed  Google Scholar 

  • Connor JP, Young RM, Lawford BR, Ritchie TL, Noble EP (2002) D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence. Eur Psychiatry 17:17–23

    Article  CAS  PubMed  Google Scholar 

  • Cordeiro Q, Siqueira-Roberto J, Zung S, Vallada H (2009) Association between the DRD2-141C insertion/deletion polymorphism and schizophrenia. Arq Neuropsiquiatr 67:191–194

    Article  PubMed  Google Scholar 

  • Cravchik A, Sibley DR, Gejman PV (1996) Functional analysis of the human D2 dopamine receptor missense variants. J Biol Chem 271:26013–26017

    Article  CAS  PubMed  Google Scholar 

  • Dani JA, Harris RA (2005) Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nat Neurosci 8:1465–1470. https://doi.org/10.1038/nn1580

    Article  CAS  PubMed  Google Scholar 

  • Darke S, Hall W (1995) Levels and correlates of polydrug use among heroin users and regular amphetamine users. Drug Alcohol Depend 39:231–235

    Article  CAS  PubMed  Google Scholar 

  • Darke S, Ross J (1997) Polydrug dependence and psychiatric comorbidity among heroin injectors. Drug Alcohol Depend 48:135–141

    Article  CAS  PubMed  Google Scholar 

  • David SP, Mezuk B, Zandi PP, Strong D, Anthony JC, Niaura R, Uhl GR, Eaton WW (2010) Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in black and white Americans. Nicotine Tob Res 12:251–262. https://doi.org/10.1093/ntr/ntp201

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Davis C, Levitan RD, Kaplan AS, Carter J, Reid C, Curtis C, Patte K, Hwang R, Kennedy JL (2008) Reward sensitivity and the D2 dopamine receptor gene: a case-control study of binge eating disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 32:620–628. https://doi.org/10.1016/j.pnpbp.2007.09.024

    Article  CAS  Google Scholar 

  • Davis C, Levitan RD, Yilmaz Z, Kaplan AS, Carter JC, Kennedy JL (2012) Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes. Prog Neuro-Psychopharmacol Biol Psychiatry 38:328–335. https://doi.org/10.1016/j.pnpbp.2012.05.002

    Article  CAS  Google Scholar 

  • De Ruyck K, Nackaerts K, Beels L, Werbrouck J, De Volder A, Meysman M, Salhi B, Van Meerbeeck J, Thierens H (2010) Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. Pharmacogenomics 11:1053–1063. https://doi.org/10.2217/pgs.10.75

    Article  PubMed  Google Scholar 

  • Di Chiara G, Bassareo V, Fenu S, De Luca MA, Spina L, Cadoni C, Acquas E, Carboni E, Valentini V, Lecca D (2004) Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology 47(Suppl 1):227–241. https://doi.org/10.1016/j.neuropharm.2004.06.032

    Article  PubMed  CAS  Google Scholar 

  • Dick DM, Agrawal A, Wang JC, Hinrichs A, Bertelsen S, Bucholz KK, Schuckit M, Kramer J, Nurnberger J Jr, Tischfield J, Edenberg HJ, Goate A, Bierut LJ (2007a) Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. Addiction 102:1131–1139. https://doi.org/10.1111/j.1360-0443.2007.01871.x

    Article  PubMed  Google Scholar 

  • Dick DM, Wang JC, Plunkett J, Aliev F, Hinrichs A, Bertelsen S, Budde JP, Goldstein EL, Kaplan D, Edenberg HJ, Nurnberger J Jr, Hesselbrock V, Schuckit M, Kuperman S, Tischfield J, Porjesz B, Begleiter H, Bierut LJ, Goate A (2007b) Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcohol Clin Exp Res 31:1645–1653

    Article  CAS  PubMed  Google Scholar 

  • Dick DM, Meyers JL, Rose RJ, Kaprio J, Kendler KS (2011) Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture. Alcohol Clin Exp Res 35:2152–2161. https://doi.org/10.1111/j.1530-0277.2011.01564.x

    Article  PubMed  PubMed Central  Google Scholar 

  • Dinwiddie SH, Cottler L, Compton W, Abdallah AB (1996) Psychopathology and HIV risk behaviors among injection drug users in and out of treatment. Drug Alcohol Depend 43:1–11

    Article  CAS  PubMed  Google Scholar 

  • Dluzen DE, Anderson LI (1997) Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats. Neurosci Lett 230:140–142

    Article  CAS  PubMed  Google Scholar 

  • Doehring A, Hentig N, Graff J, Salamat S, Schmidt M, Geisslinger G, Harder S, Lotsch J (2009) Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. Pharmacogenet Genomics 19:407–414. https://doi.org/10.1097/FPC.0b013e328320a3fd

    Article  CAS  PubMed  Google Scholar 

  • Doll BB, Hutchison KE, Frank MJ (2011) Dopaminergic genes predict individual differences in susceptibility to confirmation bias. J Neurosci 31:6188–6198. https://doi.org/10.1523/JNEUROSCI.6486-10.2011

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Du Y, Wan YJ (2009) The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americans. Alcohol Clin Exp Res 33:2103–2112. https://doi.org/10.1111/j.1530-0277.2009.01050.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV (2003) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12:205–216

    Article  CAS  PubMed  Google Scholar 

  • Dubertret C, Gorwood P, Gouya L, Deybach JC, Ades J (2001) Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients. Schizophr Res 49:203–212

    Article  CAS  PubMed  Google Scholar 

  • Dubertret C, Gouya L, Hanoun N, Deybach JC, Ades J, Hamon M, Gorwood P (2004) The 3′ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. Schizophr Res 67:75–85

    Article  PubMed  Google Scholar 

  • Ducci F, Kaakinen M, Pouta A, Hartikainen AL, Veijola J, Isohanni M, Charoen P, Coin L, Hoggart C, Ekelund J, Peltonen L, Freimer N, Elliott P, Schumann G, Jarvelin MR (2011) TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. Biol Psychiatry 69:650–660. https://doi.org/10.1016/j.biopsych.2010.09.055

    Article  CAS  PubMed  Google Scholar 

  • Edenberg HJ, Foroud T (2006) The genetics of alcoholism: identifying specific genes through family studies. Addict Biol 11:386–396

    Article  PubMed  Google Scholar 

  • Eicher JD, Powers NR, Cho K, Miller LL, Mueller KL, Ring SM, Tomblin JB, Gruen JR (2013) Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. PLoS One 8:e63762. https://doi.org/10.1371/journal.pone.0063762

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eisenberg DTA, MacKillop J, Modi M, Beauchemin J, Dang D, Lisman SA, Koji Lum J, Wilson DS (2007) Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study. Behav Brain Funct. https://doi.org/10.1186/1744-9081-3-2

  • Fan H, Zhang F, Xu Y, Huang X, Sun G, Song Y, Long H, Liu P (2010) An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population. Neurosci Lett 477:53–56. https://doi.org/10.1016/j.neulet.2009.11.017

    Article  CAS  PubMed  Google Scholar 

  • Finckh U, Giraldo-Velasquez M, Pelz J, Otto G, Sander T, Schmidt LG, Rommelspacher H, Rolfs A (1996) Dopamine D2 receptor gene (DRD2) haplotypes in Caucasians. Gene 179:251–255

    Article  CAS  PubMed  Google Scholar 

  • Finckh U, Rommelspacher H, Kuhn S, Dufeu P, Otto G, Heinz A, Dettling M, Giraldo-Velasquez M, Pelz J, Graf KJ, Harms H, Sander T, Schmidt LG, Rolfs A (1997) Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism. Pharmacogenetics 7:271–281

    Article  CAS  PubMed  Google Scholar 

  • Fiorentini C, Guerra N, Facchetti M, Finardi A, Tiberio L, Schiaffonati L, Spano P, Missale C (2002) Nerve growth factor regulates dopamine D(2) receptor expression in prolactinoma cell lines via p75(NGFR)-mediated activation of nuclear factor-kappaB. Mol Endocrinol 16:353–366

    CAS  PubMed  Google Scholar 

  • Frank MJ, Hutchison K (2009) Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms. Neuroscience 164:131–140. https://doi.org/10.1016/j.neuroscience.2009.04.048

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE (2007) Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proc Natl Acad Sci U S A 104:16311–16316. https://doi.org/10.1073/pnas.0706111104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garrido E, Palomo T, Ponce G, Garcia-Consuegra I, Jimenez-Arriero MA, Hoenicka J (2011) The ANKK1 protein associated with addictions has nuclear and cytoplasmic localization and shows a differential response of Ala239Thr to apomorphine. Neurotox Res 20:32–39. https://doi.org/10.1007/s12640-010-9219-6

    Article  CAS  PubMed  Google Scholar 

  • Gelernter J, Kranzler H (1999) D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype. Neuropsychopharmacology 20:640–649. https://doi.org/10.1016/S0893-133X(98)00110-9

    Article  CAS  PubMed  Google Scholar 

  • Gelernter J, O’Malley S, Risch N, Kranzler HR, Krystal J, Merikangas K, Kennedy JL, Kidd KK (1991) No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA 266:1801–1807

    Article  CAS  PubMed  Google Scholar 

  • Gelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang BZ, Kranzler HR, Farrer L (2006) Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Hum Mol Genet 15:3498–3507

    Article  CAS  PubMed  Google Scholar 

  • Gelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, Kranzler HR (2007) Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus. Biol Psychiatry 61:119–126

    Article  CAS  PubMed  Google Scholar 

  • Glatt SJ, Faraone SV, Lasky-Su JA, Kanazawa T, Hwu HG, Tsuang MT (2009) Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan. Mol Psychiatry 14:885–893. https://doi.org/10.1038/mp.2008.30

    Article  CAS  PubMed  Google Scholar 

  • Gong DY, Li ZP, Li B, Gan CB, Wang X (2011) Influence of a genetic signature on therapeutic effects of clozapine in schizophrenia subjects from South China. ITME:501–504

    Google Scholar 

  • Grant JD, Agrawal A, Bucholz KK, Madden PA, Pergadia ML, Nelson EC, Lynskey MT, Todd RD, Todorov AA, Hansell NK, Whitfield JB, Martin NG, Heath AC (2009) Alcohol consumption indices of genetic risk for alcohol dependence. Biol Psychiatry 66:795–800. https://doi.org/10.1016/j.biopsych.2009.05.018

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grevle L, Guzey C, Hadidi H, Brennersted R, Idle JR, Aasly J (2000) Allelic association between the DRD2 TaqI A polymorphism and Parkinson’s disease. Mov Disord 15:1070–1074

    Article  CAS  PubMed  Google Scholar 

  • Hamajima N, Ito H, Matsuo K, Saito T, Tajima K, Ando M, Yoshida K, Takahashi T (2002) Association between smoking habits and dopamine receptor D2 taqI A A2 allele in Japanese males: a confirmatory study. J Epidemiol 12:297–304

    Article  PubMed  Google Scholar 

  • Hamilton AS, Lessov-Schlaggar CN, Cockburn MG, Unger JB, Cozen W, Mack TM (2006) Gender differences in determinants of smoking initiation and persistence in California twins. Cancer Epidemiol Biomark Prev 15:1189–1197. https://doi.org/10.1158/1055-9965.EPI-05-0675

    Article  Google Scholar 

  • Hanninen K, Katila H, Kampman O, Anttila S, Illi A, Rontu R, Mattila KM, Hietala J, Hurme M, Leinonen E, Lehtimaki T (2006) Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia. Neurosci Lett 407:195–198. https://doi.org/10.1016/j.neulet.2006.08.041

    Article  PubMed  CAS  Google Scholar 

  • Hardie TL, Moss HB, Lynch KG (2006) Genetic correlations between smoking initiation and smoking behaviors in a twin sample. Addict Behav 31:2030–2037. https://doi.org/10.1016/j.addbeh.2006.02.010

    Article  PubMed  Google Scholar 

  • Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1997) Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 27:1381–1396

    Article  CAS  PubMed  Google Scholar 

  • Heinz A, Siessmeier T, Wrase J, Hermann D, Klein S, Grusser SM, Flor H, Braus DF, Buchholz HG, Grunder G, Schreckenberger M, Smolka MN, Rosch F, Mann K, Bartenstein P (2004) Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving. Am J Psychiatry 161:1783–1789. https://doi.org/10.1176/appi.ajp.161.10.1783

    Article  PubMed  Google Scholar 

  • Herzberg I, Valencia-Duarte AV, Kay VA, White DJ, Muller H, Rivas IC, Mesa SC, Cuartas M, Garcia J, Bedoya G, Cornejo W, Ruiz-Linares A, Kremeyer B (2010) Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate. Psychiatr Genet 20:179–183. https://doi.org/10.1097/YPG.0b013e32833a215a

    Article  PubMed  Google Scholar 

  • Hettinger JA, Liu X, Hudson ML, Lee A, Cohen IL, Michaelis RC, Schwartz CE, Lewis SM, Holden JJ (2012) DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families. Behav Brain Funct 8:19. https://doi.org/10.1186/1744-9081-8-19

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hill SY, Zezza N, Wipprecht G, Locke J, Neiswanger K (1999) Personality traits and dopamine receptors (D2 and D4): linkage studies in families of alcoholics. Am J Med Genet 88:634–641

    Article  CAS  PubMed  Google Scholar 

  • Hill SY, Hoffman EK, Zezza N, Thalamuthu A, Weeks DE, Matthews AG, Mukhopadhyay I (2008) Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families. Am J Med Genet B Neuropsychiatr Genet 147B:517–526. https://doi.org/10.1002/ajmg.b.30630

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hirvonen M (2009) Genetic factors in the regulation of striatal and Extrastriatal dopamine D2 receptor expression. doria17-kk.lib.helsinki.fi

  • Hirvonen M, Laakso A, Nagren K, Rinne JO, Pohjalainen T, Hietala J (2004) C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo. Mol Psychiatry 9:1060–1061. https://doi.org/10.1038/sj.mp.4001561

    Article  CAS  PubMed  Google Scholar 

  • Hirvonen M, Laakso A, Nagren K, Rinne JO, Pohjalainen T, Hietala J (2005) C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo. Mol Psychiatry 10:889

    Article  CAS  Google Scholar 

  • Hirvonen MM, Lumme V, Hirvonen J, Pesonen U, Nagren K, Vahlberg T, Scheinin H, Hietala J (2009) C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo. Prog Neuro-Psychopharmacol Biol Psychiatry 33:630–636. https://doi.org/10.1016/j.pnpbp.2009.02.021

    Article  CAS  Google Scholar 

  • Ho MK, Goldman D, Heinz A, Kaprio J, Kreek MJ, Li MD, Munafo MR, Tyndale RF (2010) Breaking barriers in the genomics and pharmacogenetics of drug addiction. Clin Pharmacol Ther 88:779–791. clpt2010175 [pii]881038/clpt.2010.175

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoenicka J, Aragues M, Rodriguez-Jimenez R, Ponce G, Martinez I, Rubio G, Jimenez-Arriero MA, Palomo T, Psychosis, Addictions Research G (2006) C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients. Acta Psychiatr Scand 114:435–438. https://doi.org/10.1111/j.1600-0447.2006.00874.x

    Article  CAS  PubMed  Google Scholar 

  • Hoenicka J, Quinones-Lombrana A, Espana-Serrano L, Alvira-Botero X, Kremer L, Perez-Gonzalez R, Rodriguez-Jimenez R, Jimenez-Arriero MA, Ponce G, Palomo T (2010) The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Biol Psychiatry 67:3–11. https://doi.org/10.1016/j.biopsych.2009.08.012

    Article  CAS  PubMed  Google Scholar 

  • Hou QF, Li SB (2009) Potential association of DRD2 and DAT1 genetic variation with heroin dependence. Neurosci Lett 464:127–130. https://doi.org/10.1016/j.neulet.2009.08.004

    Article  CAS  PubMed  Google Scholar 

  • Huang W, Payne TJ, Ma JZ, Beuten J, Dupont RT, Inohara N, Li MD (2009) Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology 34:319–330

    Article  CAS  PubMed  Google Scholar 

  • Huertas E, Ponce G, Koeneke MA, Poch C, Espana-Serrano L, Palomo T, Jimenez-Arriero MA, Hoenicka J (2010) The D2 dopamine receptor gene variant C957T affects human fear conditioning and aversive priming. Genes Brain Behav 9:103–109. https://doi.org/10.1111/j.1601-183X.2009.00543.x

    Article  CAS  PubMed  Google Scholar 

  • Huertas E, Buhler KM, Echeverry-Alzate V, Gimenez T, Lopez-Moreno JA (2012) C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate. Genes Brain Behav 11:677–683. https://doi.org/10.1111/j.1601-183X.2012.00793.x

    Article  CAS  PubMed  Google Scholar 

  • Hwang R, Shinkai T, De Luca V, Muller DJ, Ni X, Macciardi F, Potkin S, Lieberman JA, Meltzer HY, Kennedy JL (2005) Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations. Psychopharmacology 181:179–187. https://doi.org/10.1007/s00213-005-2223-5

    Article  CAS  PubMed  Google Scholar 

  • Ikeda M, Yamanouchi Y, Kinoshita Y, Kitajima T, Yoshimura R, Hashimoto S, O’Donovan MC, Nakamura J, Ozaki N, Iwata N (2008) Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics 9:1437–1443. https://doi.org/10.2217/14622416.9.10.1437

    Article  CAS  PubMed  Google Scholar 

  • Inada T, Arinami T, Yagi G (1999) Association between a polymorphism in the promoter region of the dopamine D2 receptor gene and schizophrenia in Japanese subjects: replication and evaluation for antipsychotic-related features. Int J Neuropsychopharmacol 2:181–186. https://doi.org/10.1017/S1461145799001492

    Article  CAS  PubMed  Google Scholar 

  • Ishiguro H, Arinami T, Saito T, Akazawa S, Enomoto M, Mitushio H, Fujishiro H, Tada K, Akimoto Y, Mifune H, Shioduka S, Hamaguchi H, Toru M, Shibuya H (1998) Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism. Alcohol Clin Exp Res 22:845–848

    CAS  PubMed  Google Scholar 

  • John U, Meyer C, Rumpf HJ, Hapke U (2003) Probabilities of alcohol high-risk drinking, abuse or dependence estimated on grounds of tobacco smoking and nicotine dependence. Addiction 98:805–814

    Article  PubMed  Google Scholar 

  • Jonsson EG, Nothen MM, Grunhage F, Farde L, Nakashima Y, Propping P, Sedvall GC (1999a) Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 4:290–296

    Article  CAS  PubMed  Google Scholar 

  • Jonsson EG, Nothen MM, Neidt H, Forslund K, Rylander G, Mattila-Evenden M, Asberg M, Propping P, Sedvall GC (1999b) Association between a promoter polymorphism in the dopamine D2 receptor gene and schizophrenia. Schizophr Res 40:31–36

    Article  CAS  PubMed  Google Scholar 

  • Juyal RC, Das M, Punia S, Behari M, Nainwal G, Singh S, Swaminath PV, Govindappa ST, Jayaram S, Muthane UB, Thelma BK (2006) Genetic susceptibility to Parkinson’s disease among south and north Indians: I. Role of polymorphisms in dopamine receptor and transporter genes and association of DRD4 120-bp duplication marker. Neurogenetics 7:223–229. https://doi.org/10.1007/s10048-006-0048-y

    Article  CAS  PubMed  Google Scholar 

  • Kawamura Y, Takahashi T, Liu X, Nishida N, Noda Y, Yoshikawa A, Umekage T, Sasaki T (2013) Variation in the DRD2 gene affects impulsivity in intertemporal choice. Open J Psychiatry. https://doi.org/10.4236/ojpsych.2013.31005

  • Kendler KS, Myers J, Dick D, Prescott CA (2010) The relationship between genetic influences on alcohol dependence and on patterns of alcohol consumption. Alcohol Clin Exp Res 34:1058–1065. https://doi.org/10.1111/j.1530-0277.2010.01181.x

    Article  PubMed  PubMed Central  Google Scholar 

  • Kidorf M, Brooner RK, King VL, Chutuape MA, Stitzer ML (1996) Concurrent validity of cocaine and sedative dependence diagnoses in opioid-dependent outpatients. Drug Alcohol Depend 42:117–123

    Article  CAS  PubMed  Google Scholar 

  • Kishida I, Kawanishi C, Furuno T, Kato D, Ishigami T, Kosaka K (2004) Association in Japanese patients between neuroleptic malignant syndrome and functional polymorphisms of the dopamine D(2) receptor gene. Mol Psychiatry 9:293–298. https://doi.org/10.1038/sj.mp.4001422

    Article  CAS  PubMed  Google Scholar 

  • Klee H, Faugier J, Hayes C, Boulton T, Morris J (1990) AIDS-related risk behaviour, polydrug use and temazepam. Br J Addict 85:1125–1132

    Article  CAS  PubMed  Google Scholar 

  • Klein TA, Neumann J, Reuter M, Hennig J, von Cramon DY, Ullsperger M (2007) Genetically determined differences in learning from errors. Science 318:1642–1645. https://doi.org/10.1126/science.1145044

    Article  CAS  PubMed  Google Scholar 

  • Konishi T, Calvillo M, Leng AS, Lin KM, Wan YJ (2004) Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans. Alcohol 32:45–52. https://doi.org/10.1016/j.alcohol.2003.11.002

    Article  CAS  PubMed  Google Scholar 

  • Laakso A, Pohjalainen T, Bergman J, Kajander J, Haaparanta M, Solin O, Syvalahti E, Hietala J (2005) The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects. Pharmacogenet Genomics 15:387–391

    Article  CAS  PubMed  Google Scholar 

  • Lan J, Song M, Pan C, Zhuang G, Wang Y, Ma W, Chu Q, Lai Q, Xu F, Li Y, Liu L, Wang W (2009) Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese. J Hum Genet 54:457–460. https://doi.org/10.1038/jhg.2009.60

    Article  CAS  PubMed  Google Scholar 

  • Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241–247

    Article  CAS  PubMed  Google Scholar 

  • Laruelle M, Gelernter J, Innis RB (1998) D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene. Mol Psychiatry 3:261–265

    Article  CAS  PubMed  Google Scholar 

  • Lawford BR, Young RM, Rowell JA, Gibson JN, Feeney GF, Ritchie TL, Syndulko K, Noble EP (1997) Association of the D2 dopamine receptor A1 allele with alcoholism: medical severity of alcoholism and type of controls. Biol Psychiatry 41:386–393. https://doi.org/10.1016/S0006-3223(96)00478-7

    Article  CAS  PubMed  Google Scholar 

  • Lawford BR, Young RM, Swagell CD, Barnes M, Burton SC, Ward WK, Heslop KR, Shadforth S, van Daal A, Morris CP (2005) The C/C genotype of the C957T polymorphism of the dopamine D2 receptor is associated with schizophrenia. Schizophr Res 73:31–37. https://doi.org/10.1016/j.schres.2004.08.020

    Article  PubMed  Google Scholar 

  • Le Foll B, Gallo A, Le Strat Y, Lu L, Gorwood P (2009) Genetics of dopamine receptors and drug addiction: a comprehensive review. Behav Pharmacol 20:1–17. https://doi.org/10.1097/FBP.0b013e3283242f05

    Article  PubMed  CAS  Google Scholar 

  • Lee MS, Lee KJ, Kwak DI (1997) No association between the dopamine D2 receptor gene and Korean alcoholism. Psychiatr Genet 7:93–95

    Article  CAS  PubMed  Google Scholar 

  • Lee CC, Chou IC, Tsai CH, Wang TR, Li TC, Tsai FJ (2005) Dopamine receptor D2 gene polymorphisms are associated in Taiwanese children with Tourette syndrome. Pediatr Neurol 33:272–276. https://doi.org/10.1016/j.pediatrneurol.2005.05.005

    Article  PubMed  Google Scholar 

  • Lencz T, Robinson DG, Xu K, Ekholm J, Sevy S, Gunduz-Bruce H, Woerner MG, Kane JM, Goldman D, Malhotra AK (2006) DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. Am J Psychiatry 163:529–531. https://doi.org/10.1176/appi.ajp.163.3.529

    Article  PubMed  Google Scholar 

  • Lencz T, Robinson DG, Napolitano B, Sevy S, Kane JM, Goldman D, Malhotra AK (2010) DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia. Pharmacogenet Genomics 20:569–572. https://doi.org/10.1097/FPC.0b013e32833ca24b

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lerman C, Caporaso NE, Audrain J, Main D, Bowman ED, Lockshin B, Boyd NR, Shields PG (1999) Evidence suggesting the role of specific genetic factors in cigarette smoking. Health Psychol 18:14–20

    Article  CAS  PubMed  Google Scholar 

  • Li TK (2000) Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. J Stud Alcohol 61:5–12

    Article  CAS  PubMed  Google Scholar 

  • Li MD (2003) The genetics of smoking related behavior: a brief review. Am J Med Sci 326:168–173

    Article  PubMed  Google Scholar 

  • Li T, Liu X, Sham PC, Aitchison KJ, Cai G, Arranz MJ, Deng H, Liu J, Kirov G, Murray RM, Collier DA (1999) Association analysis between dopamine receptor genes and bipolar affective disorder. Psychiatry Res 86:193–201

    Article  CAS  PubMed  Google Scholar 

  • Li T, Liu X, Zhao J, Hu X, Ball DM, Loh e-W, Sham PC, Collier DA (2002) Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. Am J Med Genet 114:329–335

    Article  PubMed  Google Scholar 

  • Li MD, Ma JZ, Cheng R, Dupont RT, Williams NJ, Crews KM, Payne TJ, Elston RC (2003a) A genome-wide scan to identify loci for smoking rate in the Framingham heart study population. BMC Genet 4:S103

    Article  PubMed  PubMed Central  Google Scholar 

  • Li MD, Cheng R, Ma JZ, Swan GE (2003b) A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 98:23–31

    Article  PubMed  Google Scholar 

  • Li MD, Ma JZ, Beuten J (2004) Progress in searching for susceptibility loci and genes for smoking-related behaviour. Clin Genet 66:382–392. https://doi.org/10.1111/j.1399-0004.2004.00302.x

    Article  CAS  PubMed  Google Scholar 

  • Little HJ (2000) Behavioral mechanisms underlying the link between smoking and drinking. Alcohol Res Health 24:215–224

    CAS  PubMed  Google Scholar 

  • Litwin T, Gromadzka G, Samochowiec J, Grzywacz A, Czlonkowski A, Czlonkowska A (2013) Association of dopamine receptor gene polymorphisms with the clinical course of Wilson disease. JIMD Rep 8:73–80. https://doi.org/10.1007/8904_2012_163

    Article  CAS  PubMed  Google Scholar 

  • Lu RB, Ko HC, Chang FM, Castiglione CM, Schoolfield G, Pakstis AJ, Kidd JR, Kidd KK (1996) No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct Taiwanese populations. Biol Psychiatry 39:419–429

    Article  CAS  PubMed  Google Scholar 

  • Lucht M, Samochowiec A, Samochowiec J, Jasiewicz A, Grabe HJ, Geissler I, Rimmbach C, Rosskopf D, Grzywacz A, Wysiecka JP, Tybura P, Brzuchalski B, Bienkowski P (2010) Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. Prog Neuro-Psychopharmacol Biol Psychiatry 34:45–49. https://doi.org/10.1016/j.pnpbp.2009.08.024

    Article  CAS  Google Scholar 

  • McGue M (1999) The behavioral genetics of alcoholism. Curr Dir Psychol Sci 8:109–115

    Article  Google Scholar 

  • McGuire V, Van Den Eeden SK, Tanner CM, Kamel F, Umbach DM, Marder K, Mayeux R, Ritz B, Ross GW, Petrovitch H, Topol B, Popat RA, Costello S, Manthripragada AD, Southwick A, Myers RM, Nelson LM (2011) Association of DRD2 and DRD3 polymorphisms with Parkinson’s disease in a multiethnic consortium. J Neurol Sci 307:22–29. https://doi.org/10.1016/j.jns.2011.05.031

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meyers JL, Nyman E, Loukola A, Rose RJ, Kaprio J, Dick DM (2013) The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems. Addict Biol 18:523–536. https://doi.org/10.1111/j.1369-1600.2012.00490.x

    Article  CAS  PubMed  Google Scholar 

  • Mileva-Seitz V, Fleming AS, Meaney MJ, Mastroianni A, Sinnwell JP, Steiner M, Atkinson L, Levitan RD, Matthews SG, Kennedy JL, Sokolowski MB (2012) Dopamine receptors D1 and D2 are related to observed maternal behavior. Genes Brain Behav 11:684–694. https://doi.org/10.1111/j.1601-183X.2012.00804.x

    Article  CAS  PubMed  Google Scholar 

  • Morley KI, Medland SE, Ferreira MA, Lynskey MT, Montgomery GW, Heath AC, Madden PA, Martin NG (2006) A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. Behav Genet 36:87–99

    Article  PubMed  Google Scholar 

  • Morton LM, Wang SS, Bergen AW, Chatterjee N, Kvale P, Welch R, Yeager M, Hayes RB, Chanock SJ, Caporaso NE (2006) DRD2 genetic variation in relation to smoking and obesity in the prostate, lung, colorectal, and ovarian cancer screening trial. Pharmacogenet Genomics 16:901–910. https://doi.org/10.1097/01.fpc.0000230417.20468.d0

    Article  CAS  PubMed  Google Scholar 

  • Moyer RA, Wang D, Papp AC, Smith RM, Duque L, Mash DC, Sadee W (2011) Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse. Neuropsychopharmacology 36:753–762. https://doi.org/10.1038/npp.2010.208

    Article  CAS  PubMed  Google Scholar 

  • Munafo M, Clark T, Johnstone E, Murphy M, Walton R (2004) The genetic basis for smoking behavior: a systematic review and meta-analysis. Nicotine Tob Res 6:583–597. https://doi.org/10.1080/14622200410001734030

    Article  CAS  PubMed  Google Scholar 

  • Munafo MR, Matheson IJ, Flint J (2007) Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias. Mol Psychiatry 12:454–461

    Article  CAS  PubMed  Google Scholar 

  • Munafo MR, Timpson NJ, David SP, Ebrahim S, Lawlor DA (2009) Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data. Nicotine Tob Res 11:64–76. https://doi.org/10.1093/ntr/ntn012

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Munro CA, McCaul ME, Wong DF, Oswald LM, Zhou Y, Brasic J, Kuwabara H, Kumar A, Alexander M, Ye W, Wand GS (2006) Sex differences in striatal dopamine release in healthy adults. Biol Psychiatry 59:966–974. https://doi.org/10.1016/j.biopsych.2006.01.008

    Article  CAS  PubMed  Google Scholar 

  • Neiswanger K, Kaplan BB, Hill SY (1995) What can the DRD2/alcoholism story teach us about association studies in psychiatric genetics? Am J Med Genet 60:272–275. https://doi.org/10.1002/ajmg.1320600403

    Article  CAS  PubMed  Google Scholar 

  • Nelson EC, Lynskey MT, Heath AC, Wray N, Agrawal A, Shand FL, Henders AK, Wallace L, Todorov AA, Schrage AJ, Saccone NL, Madden PA, Degenhardt L, Martin NG, Montgomery GW (2013) ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. JAMA Psychiat 70:325–333. https://doi.org/10.1001/jamapsychiatry.2013.282

    Article  CAS  Google Scholar 

  • Nemoda Z, Lyons-Ruth K, Szekely A, Bertha E, Faludi G, Sasvari-Szekely M (2010) Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Behav Brain Funct 6:4. https://doi.org/10.1186/1744-9081-6-4

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Neville MJ, Johnstone EC, Walton RT (2004) Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 23:540–545

    Article  CAS  PubMed  Google Scholar 

  • Nisoli E, Brunani A, Borgomainerio E, Tonello C, Dioni L, Briscini L, Redaelli G, Molinari E, Cavagnini F, Carruba MO (2007) D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eating-related psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity. Eat Weight Disord 12:91–96

    Article  CAS  PubMed  Google Scholar 

  • Noble EP (2003) D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet 116B:103–125. https://doi.org/10.1002/ajmg.b.10005

    Article  PubMed  Google Scholar 

  • Noble EP, Blum K (1993) Alcoholism and the D2 dopamine receptor gene. JAMA 270:1547–1548

    Article  CAS  PubMed  Google Scholar 

  • Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ (1991) Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48:648–654

    Article  CAS  PubMed  Google Scholar 

  • Noble EP, Blum K, Khalsa ME, Ritchie T, Montgomery A, Wood RC, Fitch RJ, Ozkaragoz T, Sheridan PJ, Anglin MD et al (1993) Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug Alcohol Depend 33:271–285

    Article  CAS  PubMed  Google Scholar 

  • Noble EP, St Jeor ST, Ritchie T, Syndulko K, St Jeor SC, Fitch RJ, Brunner RL, Sparkes RS (1994) D2 dopamine receptor gene and cigarette smoking: a reward gene? Med Hypotheses 42:257–260

    Article  CAS  PubMed  Google Scholar 

  • Noble EP, Zhang X, Ritchie TL, Sparkes RS (2000) Haplotypes at the DRD2 locus and severe alcoholism. Am J Med Genet 96:622–631

    Article  CAS  PubMed  Google Scholar 

  • Ohara K, Nagai M, Tani K, Nakamura Y, Ino A, Ohara K (1998) Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia. Psychiatry Res 81:117–123

    Article  CAS  PubMed  Google Scholar 

  • Oliveri RL, Annesi G, Zappia M, Civitelli D, De Marco EV, Pasqua AA, Annesi F, Spadafora P, Gambardella A, Nicoletti G, Branca D, Caracciolo M, Aguglia U, Quattrone A (2000) The dopamine D2 receptor gene is a susceptibility locus for Parkinson’s disease. Mov Disord 15:127–131

    Article  CAS  PubMed  Google Scholar 

  • Ovchinnikov IV, Druzina E, Ovtchinnikova O, Zagorovskaya T, Nebarakova T, Anokhina IP (1999) Polymorphism of dopamine D2 and D4 receptor genes and Slavic-surnamed alcoholic patients. Addict Biol 4:399–404. https://doi.org/10.1080/13556219971380

    Article  CAS  PubMed  Google Scholar 

  • Perkins KA, Lerman C, Grottenthaler A, Ciccocioppo MM, Milanak M, Conklin CA, Bergen AW, Benowitz NL (2008) Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood. Behav Pharmacol 19:641–649. https://doi.org/10.1097/FBP.0b013e32830c367c

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Persico AM, Bird G, Gabbay FH, Uhl GR (1996) D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. Biol Psychiatry 40:776–784. https://doi.org/10.1016/0006-3223(95)00483-1

    Article  CAS  PubMed  Google Scholar 

  • Pohjalainen T, Rinne JO, Nagren K, Lehikoinen P, Anttila K, Syvalahti EK, Hietala J (1998) The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatry 3:256–260

    Article  CAS  PubMed  Google Scholar 

  • Pohjalainen T, Nagren K, Syvalahti EK, Hietala J (1999) The dopamine D2 receptor 5′-flanking variant, -141C Ins/Del, is not associated with reduced dopamine D2 receptor density in vivo. Pharmacogenetics 9:505–509

    CAS  PubMed  Google Scholar 

  • Ponce G, Jimenez-Arriero MA, Rubio G, Hoenicka J, Ampuero I, Ramos JA, Palomo T (2003) The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. Eur Psychiatry 18:356–360

    Article  CAS  PubMed  Google Scholar 

  • Ponce G, Hoenicka J, Jimenez-Arriero MA, Rodriguez-Jimenez R, Aragues M, Martin-Sune N, Huertas E, Palomo T (2008) DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. Br J Psychiatry 193:121–125. https://doi.org/10.1192/bjp.bp.107.041582

    Article  CAS  PubMed  Google Scholar 

  • Prasad P, Ambekar A, Vaswani M (2010) Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study. BMC Med Genet 11:24. https://doi.org/10.1186/1471-2350-11-24

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Preuss UW, Zill P, Koller G, Bondy B, Sokya M (2007) D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individuals. Alcohol Alcohol 42:258–266. https://doi.org/10.1093/alcalc/agm030

    Article  CAS  PubMed  Google Scholar 

  • Ritchie T, Noble EP (2003) Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem Res 28:73–82

    Article  CAS  PubMed  Google Scholar 

  • Rouge-Pont F, Usiello A, Benoit-Marand M, Gonon F, Piazza PV, Borrelli E (2002) Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors. J Neurosci 22:3293–3301. doi: 20026322

    CAS  PubMed  Google Scholar 

  • Sander T, Ladehoff M, Samochowiec J, Finckh U, Rommelspacher H, Schmidt LG (1999) Lack of an allelic association between polymorphisms of the dopamine D2 receptor gene and alcohol dependence in the German population. Alcohol Clin Exp Res 23:578–581

    Article  CAS  PubMed  Google Scholar 

  • Sasabe T, Furukawa A, Matsusita S, Higuchi S, Ishiura S (2007) Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients. Neurosci Lett 412:139–142. https://doi.org/10.1016/j.neulet.2006.10.064

    Article  CAS  PubMed  Google Scholar 

  • Schafer M, Rujescu D, Giegling I, Guntermann A, Erfurth A, Bondy B, Moller HJ (2001) Association of short-term response to haloperidol treatment with a polymorphism in the dopamine D(2) receptor gene. Am J Psychiatry 158:802–804

    Article  CAS  PubMed  Google Scholar 

  • Sery O, Drtilkova I, Theiner P, Pitelova R, Staif R, Znojil V, Lochman J, Didden W (2006) Polymorphism of DRD2 gene and ADHD. Neuro Endocrinol Lett 27:236–240

    CAS  PubMed  Google Scholar 

  • Smith L, Watson M, Gates S, Ball D, Foxcroft D (2008) Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review. Am J Epidemiol 167:125–138

    Article  PubMed  Google Scholar 

  • Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347:146–151. https://doi.org/10.1038/347146a0

    Article  CAS  PubMed  Google Scholar 

  • Spitz MR, Shi H, Yang F, Hudmon KS, Jiang H, Chamberlain RM, Amos CI, Wan Y, Cinciripini P, Hong WK, Wu X (1998) Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. J Natl Cancer Inst 90:358–363

    Article  CAS  PubMed  Google Scholar 

  • Stapleton JA, Sutherland G, O’Gara C, Spirling LI, Ball D (2011) Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy. Pharmacogenet Genomics 21:447–453. https://doi.org/10.1097/FPC.0b013e328347473a

    Article  CAS  PubMed  Google Scholar 

  • Sullivan PF, Kendler KS (1999) The genetic epidemiology of smoking. Nicotine Tob Res 1(Suppl 2):S51–S57. discussion S69–S70

    Article  PubMed  Google Scholar 

  • Sullivan D, Pinsonneault JK, Papp AC, Zhu H, Lemeshow S, Mash DC, Sadee W (2013) Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction. Transl Psychiatry 3:e222. https://doi.org/10.1038/tp.2012.146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sunahara RK, Guan HC, O’Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH, Niznik HB (1991) Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature 350:614–619. https://doi.org/10.1038/350614a0

    Article  CAS  PubMed  Google Scholar 

  • Swagell CD, Lawford BR, Hughes IP, Voisey J, Feeney GF, van Daal A, Connor JP, Noble EP, Morris CP, Young RM (2012) DRD2 C957T and TaqIA genotyping reveals gender effects and unique low-risk and high-risk genotypes in alcohol dependence. Alcohol Alcohol 47:397–403. https://doi.org/10.1093/alcalc/ags047

    Article  CAS  PubMed  Google Scholar 

  • Swan GE, Hudmon KS, Jack LM, Hemberger K, Carmelli D, Khroyan TV, Ring HZ, Hops H, Andrews JA, Tildesley E, McBride D, Benowitz N, Webster C, Wilhelmsen KC, Feiler HS, Koenig B, Caron L, Illes J, Cheng LS (2003) Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation. Cancer Epidemiol Biomark Prev 12:994–1005

    Google Scholar 

  • Thanos PK, Volkow ND, Freimuth P, Umegaki H, Ikari H, Roth G, Ingram DK, Hitzemann R (2001) Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem 78:1094–1103

    Article  CAS  PubMed  Google Scholar 

  • Thanos PK, Taintor NB, Rivera SN, Umegaki H, Ikari H, Roth G, Ingram DK, Hitzemann R, Fowler JS, Gatley SJ, Wang GJ, Volkow ND (2004) DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcohol Clin Exp Res 28:720–728

    Article  CAS  PubMed  Google Scholar 

  • Thanos PK, Rivera SN, Weaver K, Grandy DK, Rubinstein M, Umegaki H, Wang GJ, Hitzemann R, Volkow ND (2005) Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking. Life Sci 77:130–139. https://doi.org/10.1016/j.lfs.2004.10.061

    Article  CAS  PubMed  Google Scholar 

  • Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, Morris CM, Perry RH, Ferrier IN, Court JA (1997) D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7:479–484

    Article  CAS  PubMed  Google Scholar 

  • Tiberi M, Jarvie KR, Silvia C, Falardeau P, Gingrich JA, Godinot N, Bertrand L, Yang-Feng TL, Fremeau RT Jr, Caron MG (1991) Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Proc Natl Acad Sci U S A 88:7491–7495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • True WR, Heath AC, Scherrer JF, Waterman B, Goldberg J, Lin N, Eisen SA, Lyons MJ, Tsuang MT (1997) Genetic and environmental contributions to smoking. Addiction 92:1277–1287

    Article  CAS  PubMed  Google Scholar 

  • True WR, Xian H, Scherrer JF, Madden PA, Bucholz KK, Heath AC, Eisen SA, Lyons MJ, Goldberg J, Tsuang M (1999) Common genetic vulnerability for nicotine and alcohol dependence in men. Arch Gen Psychiatry 56:655–661

    Article  CAS  PubMed  Google Scholar 

  • Tupala E, Hall H, Bergstrom K, Mantere T, Rasanen P, Sarkioja T, Tiihonen J (2003) Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. Hum Brain Mapp 20:91–102. https://doi.org/10.1002/hbm.10129

    Article  PubMed  Google Scholar 

  • Usiello A, Baik JH, Rouge-Pont F, Picetti R, Dierich A, LeMeur M, Piazza PV, Borrelli E (2000) Distinct functions of the two isoforms of dopamine D2 receptors. Nature 408:199–203. https://doi.org/10.1038/35041572

    Article  CAS  PubMed  Google Scholar 

  • Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350:610–614. https://doi.org/10.1038/350610a0

    Article  PubMed  Google Scholar 

  • Vereczkei A, Demetrovics Z, Szekely A, Sarkozy P, Antal P, Szilagyi A, Sasvari-Szekely M, Barta C (2013) Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. PLoS One 8:e66592. https://doi.org/10.1371/journal.pone.0066592

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vijayan NN, Bhaskaran S, Koshy LV, Natarajan C, Srinivas L, Nair CM, Allencherry PM, Banerjee M (2007) Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population. Behav Brain Funct 3:34. https://doi.org/10.1186/1744-9081-3-34

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Voisey J, Swagell CD, Hughes IP, Morris CP, van Daal A, Noble EP, Kann B, Heslop KA, Young RM, Lawford BR (2009) The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans. Depress Anxiety 26:28–33. https://doi.org/10.1002/da.20517

    Article  CAS  PubMed  Google Scholar 

  • Voisey J, Swagell CD, Hughes IP, van Daal A, Noble EP, Lawford BR, Young RM, Morris CP (2012) A DRD2 and ANKK1 haplotype is associated with nicotine dependence. Psychiatry Res 196:285–289. https://doi.org/10.1016/j.psychres.2011.09.024

    Article  CAS  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS, Logan J, Hitzemann R, Ding YS, Pappas N, Shea C, Piscani K (1996) Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res 20:1594–1598

    Article  CAS  PubMed  Google Scholar 

  • Wang F, Simen A, Arias A, Lu QW, Zhang H (2013) A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence. Hum Genet 132:347–358. https://doi.org/10.1007/s00439-012-1251-6

    Article  CAS  PubMed  Google Scholar 

  • Wei J, Chu C, Wang Y, Yang Y, Wang Q, Li T, Zhang L, Ma X (2012) Association study of 45 candidate genes in nicotine dependence in Han Chinese. Addict Behav 37:622–626. https://doi.org/10.1016/j.addbeh.2012.01.009

    Article  PubMed  Google Scholar 

  • White MJ, Morris CP, Lawford BR, Young RM (2008) Behavioral phenotypes of impulsivity related to the ANKK1 gene are independent of an acute stressor. Behav Brain Funct 4:54. https://doi.org/10.1186/1744-9081-4-54

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • White MJ, Lawford BR, Morris CP, Young RM (2009) Interaction between DRD2 C957T polymorphism and an acute psychosocial stressor on reward-related behavioral impulsivity. Behav Genet 39:285–295. https://doi.org/10.1007/s10519-008-9255-7

    Article  PubMed  Google Scholar 

  • WHO (2008) Report on the global tobacco epidemic, 2008: the MPOWER package. World Health Organization, Geneva

    Google Scholar 

  • Wilcox CS, Noble EP, Oskooilar N (2011) ANKK1/DRD2 locus variants are associated with rimonabant efficacy in aiding smoking cessation: pilot data. J Investig Med 59:1280–1283. https://doi.org/10.231/JIM.0b013e31823581fa

    Article  CAS  PubMed  Google Scholar 

  • Wise RA, Rompre PP (1989) Brain dopamine and reward. Annu Rev Psychol 40:191–225. https://doi.org/10.1146/annurev.ps.40.020189.001203

    Article  CAS  PubMed  Google Scholar 

  • Wong AH, Buckle CE, Van Tol HH (2000) Polymorphisms in dopamine receptors: what do they tell us? Eur J Pharmacol 410:183–203

    Article  CAS  PubMed  Google Scholar 

  • Xu K, Lichtermann D, Lipsky RH, Franke P, Liu X, Hu Y, Cao L, Schwab SG, Wildenauer DB, Bau CH, Ferro E, Astor W, Finch T, Terry J, Taubman J, Maier W, Goldman D (2004) Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry 61:597–606

    Article  CAS  PubMed  Google Scholar 

  • Xu H, Kellendonk CB, Simpson EH, Keilp JG, Bruder GE, Polan HJ, Kandel ER, Gilliam TC (2007) DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability. Schizophr Res 90:104–107. https://doi.org/10.1016/j.schres.2006.10.001

    Article  PubMed  Google Scholar 

  • Yan J, Aliev F, Webb BT, Kendler KS, Williamson VS, Edenberg HJ, Agrawal A, Kos MZ, Almasy L, Nurnberger JI Jr, Schuckit MA, Kramer JR, Rice JP, Kuperman S, Goate AM, Tischfield JA, Porjesz B, Dick DM (2013) Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. Addict Biol. https://doi.org/10.1111/adb.12035

  • Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J (2007) Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. Hum Mol Genet 16:2844–2853

    Article  CAS  PubMed  Google Scholar 

  • Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J (2008) Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Alcohol Clin Exp Res 32:2117–2127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yoshida K, Hamajima N, Kozaki K, Saito H, Maeno K, Sugiura T, Ookuma K, Takahashi T (2001) Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese. Cancer Epidemiol Biomark Prev 10:403–405

    CAS  Google Scholar 

  • Zacny JP (1990) Behavioral aspects of alcohol-tobacco interactions. Recent Dev Alcohol 8:205–219

    CAS  PubMed  Google Scholar 

  • Zai CC, Ehtesham S, Choi E, Nowrouzi B, de Luca V, Stankovich L, Davidge K, Freeman N, King N, Kennedy JL, Beitchman JH (2012) Dopaminergic system genes in childhood aggression: possible role for DRD2. World J Biol Psychiatry 13:65–74. https://doi.org/10.3109/15622975.2010.543431

    Article  PubMed  Google Scholar 

  • Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee ML, Xiao T, Papp A, Wang D, Sadee W (2007) Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci U S A 104:20552–20557. https://doi.org/10.1073/pnas.0707106104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang JP, Lencz T, Malhotra AK (2010) D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis. Am J Psychiatry 167:763–772. https://doi.org/10.1176/appi.ajp.2009.09040598

    Article  PubMed  PubMed Central  Google Scholar 

  • Zheng C, Shen Y, Xu Q (2012) Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese. Neurosci Lett 518:41–44. https://doi.org/10.1016/j.neulet.2012.04.052

    Article  CAS  PubMed  Google Scholar 

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Acknowledgment

This chapter was modified from the paper published by our group in Molecular Neurobiology (Ma et al. 2015, 51: 281–299).

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  1. University of Virginia, Charlottesville, USA

    Ming D. Li

  2. Zhejiang University, Hangzhou, China

    Ming D. Li

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Li, M.D. (2018). Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking andOther Addictions. In: Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment. Springer, Singapore. https://doi.org/10.1007/978-981-10-7530-8_8

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