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Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment pp 35–46Cite as

Identified Susceptibility Loci for Nicotine Addiction Based on Genome-Wide Linkage Analyses

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Abstract

To identify susceptibility loci for smoking dependence, more than 20 genome-wide linkage studies have been conducted in different populations using a variety of nicotine dependence (ND) assessment approaches, including smoking quantity (SQ), Heaviness of Smoking Index (HSI), Fagerström Test for Nicotine Dependence (FTND), ever smoking, habitual smoking, or maximum number of cigarettes smoked in a 24 h period (CPD). This chapter provides a critical summary of the susceptibility loci identified for ND and related measures. Although a great number of identified genomic regions did not reach the level of “suggestive” or “significant” linkage or failed to be replicated in independent studies, 14 regions, located on chromosomes 3–7, 9–11, 17, 20, and 22, have been found to be “suggestive” or “significant” linkages in at least two independent samples. Among them, the regions on chromosomes 9 (9q21.33-q33), 10, 11, and 17 have received the strongest support and deserve more attention in future genetic studies on ND.

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Acknowledgment

This chapter has been modified from the paper published by our group in Human Genetics (Li 2008). The related contents are reused with permission.

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Authors and Affiliations

  1. University of Virginia, Charlottesville, USA

    Ming D. Li

  2. Zhejiang University, Hangzhou, China

    Ming D. Li

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Li, M.D. (2018). Identified Susceptibility Loci for Nicotine Addiction Based on Genome-Wide Linkage Analyses. In: Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment. Springer, Singapore. https://doi.org/10.1007/978-981-10-7530-8_4

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