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Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment pp 287–302Cite as

Nicotine Modulates Innate Immune Pathways via α7 Nicotinic Acetylcholine Receptor

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Abstract

Nicotine exerts its anti-inflammatory effects on multiple cell types and may benefit neurons in various degenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), in which an inflammation-related mechanism is implicated. Among the various nAChRs, α7, which has been identified in both neurons and immune cells and has high permeability to calcium, is believed to contribute significantly to nicotine’s anti-inflammatory and neuroprotective effects. Although nicotine has been explored clinically for the treatment of some inflammatory diseases such as ulcerative colitis, the molecular mechanisms of its actions are largely unknown. In this chapter, we provide current evidence for nicotine’s modulation of multiple immune pathways via α7 nAChRs in both neurons and immune cells. Understanding the mechanism of the nicotinic anti-inflammatory effect and neuroprotective function may guide development of novel medicines to treat infectious and neurodegenerative diseases.

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Acknowledgment

This chapter was modified from the work reported by our group in Journal of NeuroImmune Pharmacology (Cui and Li 2010). The related contents are reused with permission.

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  1. University of Virginia, Charlottesville, USA

    Ming D. Li

  2. Zhejiang University, Hangzhou, China

    Ming D. Li

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  1. Ming D. Li
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Li, M.D. (2018). Nicotine Modulates Innate Immune Pathways via α7 Nicotinic Acetylcholine Receptor. In: Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment. Springer, Singapore. https://doi.org/10.1007/978-981-10-7530-8_16

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