Abstract
Protein-protein complexes provide valuable atomic level insights for bio-molecular function. Hundreds of high-resolution (< 3 Å) X-ray structural complexes are available at the protein data bank (PDB). However, there are also a large number (over 2000) of low-resolution (> = 3 Å) structural complexes at the PDB as of June 2017. The biological insights provided by such structural complexes are invaluable in biological knowledge discovery. Therefore, it is of interest to document such information in this chapter.
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References
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H et al. The protein data bank. 2000. [cited: 2017 Mar 20]. http://www.rcsb.org/pdb/home/home.do
Dassault Systemes BIOVIA, BIOVIA Discovery Studio Visualizer, v16.1.0.15350, San Diego: Dassault Systemes; 2015 [cited: 2017 Mar 20]. Available from: http://accelrys.com/products/collaborative-science/biovia-discovery-studio/visualization-download.php
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Exercises
Exercises
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1.
What percentage of entries in PDB are low-resolution protein complexes?
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2.
Illustrate a homo tetramer complex with an example.
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3.
Differentiate between A2B and ABC protein complexes with an example.
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4.
Give a flowchart for the creation of non-redundant low-resolution protein-protein complexes.
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5.
Give a flowchart for the creation of non-redundant low-resolution protein-protein homo complexes.
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6.
Give a flowchart for the creation of non-redundant low-resolution protein-protein hetero complexes.
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7.
Show A2B2C2 and A3B3 complexes.
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8.
Illustrate a dodecamer protein complex using an example.
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9.
Illustrate a homo octamer complex using an example.
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10.
Illustrate a homo pentamer complex using an example.
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Kangueane, P., Nilofer, C. (2018). Low-Resolution Protein Complexes. In: Protein-Protein and Domain-Domain Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-7347-2_3
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DOI: https://doi.org/10.1007/978-981-10-7347-2_3
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Publisher Name: Springer, Singapore
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Online ISBN: 978-981-10-7347-2
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