Abstract
Short peptide vaccine design is based on the principle of human leukocyte antigen (HLA)-peptide (antigen) interaction. HLA-peptide binding is the bottleneck for T-cell-mediated immune response. The specific binding of peptide with defined HLA allele is highly sensitive. HLA alleles are polymorphic, and their binding to antigen peptide is selective and specific. We discuss the importance of HLA-peptide in the design of short peptides as EPITOPES for vaccine consideration.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Zhao B, Png AE, Ren EC, Kolatkar PR, Mathura VS, Sakharkar MK, et al. Compression of functional space in HLA-A sequence diversity. Hum Immunol. 2003;64(7):718–28.
Kangueane P, Sakharkar MK. Grouping of class I HLA alleles using electrostatic distribution maps of the peptide binding grooves. Methods Mol Biol. 2007;409:175–81.
Ren EC, Kangueane P, Kolatkar P, Lin MT, Tseng LH, Hansen JA. Molecular modeling of the minor histocompatibility antigen HA-1 peptides binding to HLA-A alleles. Tissue Antigens. 2000;55(1):24–30.
Kangueane P, Sakharkar MK, Kolatkar PR, Ren EC. Towards the MHC-peptide combinatorics. Hum Immunol. 2001;62(5):539–56.
Adrian PE, Rajaseger G, Mathura VS, Sakharkar MK, Kangueane P. Types of inter-atomic interactions at the MHC-peptide interface: identifying commonality from accumulated data. BMC Struct Biol. 2002;2:2.
Govindarajan KR, Kangueane P, Tan TW, Ranganathan S. MPID: MHC-peptide interaction database for sequence-structure-function information on peptides binding to MHC molecules. Bioinformatics. 2003;19(2):309–10.
Kangueane P, Sakharkar MK. HLA-peptide binding prediction using structural and modeling principles. Methods Mol Biol. 2007;409:293–9.
Kangueane P, Sakharkar MK, Lim KS, Hao H, Lin K, Chee RE, et al. Knowledge-based grouping of modeled HLA peptide complexes. Hum Immunol. 2000;61(5):460–6.
Zhao B, Mathura VS, Rajaseger G, Moochhala S, Sakharkar MK, Kangueane P. A novel MHCp binding prediction model. Hum Immunol. 2003;64(12):1123–43.
Mohanapriya A, Lulu S, Kayathri R, Kangueane P, Class II. HLA-peptide binding prediction using structural principles. Hum Immunol. 2009;70(3):159–69.
Kangueane P, Sakharkar MK. T-epitope designer: a HLA-peptide binding prediction server. Bioinformation. 2005;1(1):21–4.
Kangueane P, Sakharkar MK, Rajaseger G, Bolisetty S, Sivasekari B, Zhao B, et al. A framework to sub-type HLA supertypes. Front Biosci. 2005;10:879–86.
Mohanapriya A, Nandagond S, Shapshak P, Kangueane U, Kangueane P. A HLA-DRB supertype chart with potential overlapping peptide binding function. Bioinformation. 2010;4(7):300–9.
Kangueane P, Sakharkar MK. Structural basis for HLA-A2 supertypes. Methods Mol Biol. 2007;409:155–62.
Author information
Authors and Affiliations
Exercises
Exercises
-
1.
Write a short note on peptide vaccine and development.
-
2.
Illustrate T-cell immunity using a neat-labeled diagram.
-
3.
Expand HLA.
-
4.
Expand TCR.
-
5.
What is an allele?
-
6.
State ethnic groups.
-
7.
Illustrate HLA polymorphism.
-
8.
Explain HLA super-type.
-
9.
Illustrate a super antigen.
-
10.
Illustrate the difference in peptide binding with class I and class II HLA molecules.
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Kangueane, P., Nilofer, C. (2018). HLA-Peptide Interaction to Short Peptide Vaccine Design. In: Protein-Protein and Domain-Domain Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-7347-2_15
Download citation
DOI: https://doi.org/10.1007/978-981-10-7347-2_15
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-7346-5
Online ISBN: 978-981-10-7347-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)