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Arterial Thrombus

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The Origin and Onset of Thrombus Disease

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Abstract

Acute myocardial infarction (AMI) is a typical event in arterial thrombosis. Acute arterial thrombus is a common disease with high morbidity worldwide. The incidence of arterial thrombus is increasing in young population and has been a major social burden [1]. The mortality and disability caused by thrombosis have become a public health problem worldwide [2]. The typical pathological characteristics of acute arterial thrombus are the rupture of arterial intima soft plaque, the subsequent adhesion of platelets at the site of rupture, and the formation of white thrombus [3]. The rupture of arterial intima soft plaque is an initiator in the arterial thrombosis [4]. Some investigators propose that the soft plaque is a landmine, but the trigger of the landmine and when the landmine will be triggered are still unclear [5]. Generally, the thrombosis is proposed to be related to the damage to endothelial cells, change in the hemodynamic, and hypercoagulable state of the blood [6]. In case of atherosclerosis, the rupture of unstable plaque or the superficial erosion of arterial intima will cause the adhesion and aggregation of platelets at the site of injury, leading to the thrombosis [7]. Evidence-based medicine has shown that the pathogenesis of atherosclerosis is closely related to some risk factors such as hypertension, hyperlipidemia, hyperglycemia, obesity, and smoking [8]. However, it is hard to explain why some people without evident risk factors still develop acute arterial thrombus and those without coronary arterial plaque still develop AMI. More studies are needed to elucidate the pathogenesis of acute arterial thrombosis.

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Authors and Affiliations

  1. Tongji Hospital, Tongji University, Shanghai, China

    Lemin Wang

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Correspondence to Lemin Wang .

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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House

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Wang, L. (2018). Arterial Thrombus. In: The Origin and Onset of Thrombus Disease. Springer, Singapore. https://doi.org/10.1007/978-981-10-7344-1_2

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  • DOI: https://doi.org/10.1007/978-981-10-7344-1_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7343-4

  • Online ISBN: 978-981-10-7344-1

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