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Animal Models of Human Gammaherpesvirus Infections

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Human Herpesviruses

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1045))

Abstract

Humans are the only natural host of both Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), and this strict host tropism has hampered the development of animal models of these human gammaherpesviruses. To overcome this difficulty and develop useful models for these viruses, three main approaches have been employed: first, experimental infection of laboratory animals [mainly new-world non-human primates (NHPs)] with EBV or KSHV; second, experimental infection of NHPs (mainly old-world NHPs) with EBV- or KSHV-related gammaherpesviruses inherent to respective NHPs; and third, experimental infection of humanized mice, i.e., immunodeficient mice engrafted with functional human cells or tissues (mainly human immune system components) with EBV or KSHV. These models have recapitulated diseases caused by human gammaherpesviruses, their asymptomatic persistent infections, as well as both innate and adaptive immune responses to them, facilitating the development of novel therapeutic and prophylactic measures against these viruses.

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Acknowledgments

Work in my laboratory has been carried out in collaboration with many colleagues and students to whom I express my utmost gratitude. The work was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Research on Measures for Intractable Diseases (H21-Nanchi-094, H22-Nanchi-080, H24-Nanchi-046) and by the Practical Research Project for Rare/Intractable Diseases (16ek0109098) from Japan Agency for Medical Research and Development, AMED.

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Authors and Affiliations

  1. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan

    Shigeyoshi Fujiwara

  2. Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan

    Shigeyoshi Fujiwara

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  1. Shigeyoshi Fujiwara
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Correspondence to Shigeyoshi Fujiwara .

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  1. Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan

    Yasushi Kawaguchi

  2. Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

    Yasuko Mori

  3. Department of Virology, Nagoya University Graduation School of Medicine, Nagoya, Aichi, Japan

    Hiroshi Kimura

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Fujiwara, S. (2018). Animal Models of Human Gammaherpesvirus Infections. In: Kawaguchi, Y., Mori, Y., Kimura, H. (eds) Human Herpesviruses. Advances in Experimental Medicine and Biology, vol 1045. Springer, Singapore. https://doi.org/10.1007/978-981-10-7230-7_19

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