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Fungal Endophytes from Seaweeds: An Overview

  • Vipin Kumar Singh
  • Abhishek Kumar Dwivedy
  • Akanksha Singh
  • Simran Asawa
  • Awanindra Dwivedi
  • Nawal Kishore Dubey
Chapter

Abstract

Seaweeds are macroscopic benthic algal forms, different from microscopic algae and constitute one of the highest productive ecosystems. Marine ecosystem harbors very large diversity of seaweed endophytic fungi. Seaweeds, from different geographical locations, exhibit diversity in associated endophytes as well as secondary metabolites produced by them. Lots of works have been presented on secondary metabolites from endophytic organisms inhabiting in terrestrial and aquatic plants. However, endophytic fungi from marine macro-algae are currently emerging as a novel source of bioactive molecules. These bioactive secondary metabolites from seaweed endophytes have reported antialgal, anticancer, antimicrobial, antiplasmodial, antioxidant, insecticidal, HLE inhibitor, protein phosphatases inhibitor, tyrosine kinase inhibitor and AChE modulation activities which stimulate the scientific community for further search of new compounds. The present chapter highlights the recent developments in diversity of endophytes inhabiting the seaweeds and economically important metabolites synthesized by them as well as scope of future study in this area.

Keywords

Seaweeds Endophytes Fungi Secondary metabolites Anticancer Antimicrobial Macro algae 

Notes

Acknowledgement

Vipin Kumar Singh and Abhishek Kumar Dwivedy are thankful to Council of Scientific and Industrial Research, New Delhi for research fellowship in form of RA and SRF, respectively.

References

  1. Abdalla MA, Matasyoh JC (2014) Endophytes as producers of peptides: an overview about the recently discovered peptides from endophytic microbes. Nat Prod Bioprospect 4(5):257–270CrossRefGoogle Scholar
  2. Abdel-Lateff A, Fisch KM, Wright AD, König GM (2003) A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp. Planta Med 69(09):831–834CrossRefGoogle Scholar
  3. Alvin A, Miller KI, Neilan BA (2014) Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds. Microbiol Res 169(7):483–495CrossRefGoogle Scholar
  4. Ariffin S, Davis P, Ramasamy K (2011) Cytotoxic and antimicrobial activities of Malaysian marine endophytic fungi. Bot Mar 54(1):95–100CrossRefGoogle Scholar
  5. Ariffin SA, Ramasamy K, Davis P, Mani V, Abdulla MA (2014) Safety of Malaysian marine endophytic fungal extract S2 from a brown seaweed Turbinaria conoides. J Coast Life Med 2(7):527–534Google Scholar
  6. Bhadury P, Mohammad BT, Wright PC (2006) The current status of natural products from marine fungi and their potential as anti-infective agents. J Ind Microbiol Biotechnol 33(5):325CrossRefGoogle Scholar
  7. Bhatnagar I, Kim SK (2010) Immense essence of excellence: marine microbial bioactive compounds. Mar Drugs 8(10):2673–2701CrossRefGoogle Scholar
  8. Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR (2010) Marine natural products. Nat Prod Rep 27(2):165–237CrossRefGoogle Scholar
  9. Bode HB, Bethe B, Höfs R, Zeeck A (2002) Big effects from small changes: possible ways to explore nature's chemical diversity. Chembiochem 3(7):619–627CrossRefGoogle Scholar
  10. Brundrett MC (2006) Understanding the roles of multifunctional mycorrhizal and endophytic fungi. In: Schulz BJE, Boyle CJC, Sieber TN (eds) Microbial root endophytes. Springer, Berlin, pp 281–298CrossRefGoogle Scholar
  11. Bugni TS, Ireland CM (2004) Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat Prod Rep 21(1):143–163CrossRefGoogle Scholar
  12. Clay K, Schardl C (2002) Evolutionary origins and ecological consequences of endophyte symbiosis with grasses. Am Nat 160(S4):S99–S127CrossRefGoogle Scholar
  13. Coppejans E, Leliaert F, Dargent O, Gunasekara D, Clerck O (2009) Sri Lankan seaweeds: methodologies and field guide to the dominant species. Belg Dev Coop 6:265Google Scholar
  14. Cui CM, Li XM, Li CS, Proksch P, Wang BG (2010a) Cytoglobosins A−G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J Nat Prod 73(4):729–733CrossRefGoogle Scholar
  15. Cui CM, Li XM, Meng L, Li CS, Huang CG, Wang BG (2010b) 7-Nor-ergosterolide, a pentalactone-containing norsteroid and related steroids from the marine-derived endophytic Aspergillus ochraceus EN-31. J Nat Prod 73(11):1780–1784CrossRefGoogle Scholar
  16. de Felício R, Pavão GB, de Oliveira ALL, Erbert C, Conti R, Pupo MT, Furtado NA, Ferreira EG, Costa-Lotufo LV, Young MCM, Yokoya NS (2015) Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fungi from the Brazilian marine red alga Bostrychia tenella (Ceramiales). Rev Bras de Farmacogn 25(6):641–650CrossRefGoogle Scholar
  17. Du FY, Li XM, Li CS, Shang Z, Wang BG (2012) Cristatumins A–D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220. Bioorg Med Chem Lett 22(14):4650–4653CrossRefGoogle Scholar
  18. Du FY, Li X, Li XM, Zhu LW, Wang BG (2017) Indolediketopiperazine alkaloids from Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii. Mar Drugs 15(2):24CrossRefGoogle Scholar
  19. Elsebai MF, Kehraus S, Gütschow M, Koenig GM (2010) Spartinoxide, a new enantiomer of A82775C with inhibitory activity toward HLE from the marine-derived Fungus Phaeosphaeria spartinae. Nat Prod Commun 5(7):1071–1076PubMedGoogle Scholar
  20. Engel S, Jensen PR, Fenica W (2002) Chemical ecology of marine microbial defense. J Chem Ecol 28(10):1971–1985CrossRefGoogle Scholar
  21. Feng-Wu Wang (2012) Bioactive metabolites from Guignardia sp., an endophytic fungus residing in Undaria pinnatifida. Chin J Nat Med 10(1):72–76Google Scholar
  22. Flewelling AJ, Ellsworth KT, Sanford J, Forward E, Johnson JA, Gray CA (2013a) Macroalgal endophytes from the Atlantic coast of Canada: a potential source of antibiotic natural products? Microorganisms 1(1):175–187CrossRefGoogle Scholar
  23. Flewelling AJ, Johnson JA, Gray CA (2013b) Isolation and bioassay screening of fungal endophytes from North Atlantic marine macroalgae. Bot Mar 56(3):287–297CrossRefGoogle Scholar
  24. Gao SS, Li XM, Li CS, Proksch P, Wang BG (2011) Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S. Bioorg Med Chem Lett 21(10):2894–2897CrossRefGoogle Scholar
  25. Golinska P, Wypij M, Agarkar G, Rathod D, Dahm H, Rai M (2015) Endophytic actinobacteria of medicinal plants: diversity and bioactivity. Anton Leeuw 108(2):267–289CrossRefGoogle Scholar
  26. Guiry MD (2012) How many species of algae are there? J Phycol 48(5):1057–1063CrossRefGoogle Scholar
  27. Hardoim PR, van Overbeek LS, van Elsas JD (2008) Properties of bacterial endophytes and their proposed role in plant growth. Trends Microbiol 16(10):463–471CrossRefGoogle Scholar
  28. Hawksworth DL (2004) Fungal diversity and its implications for genetic resource collections. Stud Mycol 50:9–18Google Scholar
  29. Hsiao G, Chi WC, Pang KL, Chen JJ, Kuo YH, Wang YK, Cha HJ, Chou SC, Lee TH (2017) Hirsutane-type sesquiterpenes with inhibitory activity of microglial nitric oxide production from the red alga-derived fungus Chondrostereum sp. NTOU4196. J Nat Prod 80:1615–1622CrossRefGoogle Scholar
  30. Hulikere MM, Joshi CG, Ananda D, Poyya J, Nivya T (2016) Antiangiogenic, wound healing and antioxidant activity of Cladosporium cladosporioides (Endophytic Fungus) isolated from seaweed (Sargassum wightii). Mycology 7(4):203–211CrossRefGoogle Scholar
  31. Hyde KD, Soytong K (2008) The fungal endophyte dilemma. Fungal Divers 33(163):e173Google Scholar
  32. Kjer J, Debbab A, Aly AH, Proksch P (2010) Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products. Nat Protoc 5(3):479CrossRefGoogle Scholar
  33. König GM, Kehraus S, Seibert SF, Abdel-Lateff A, Müller D (2006) Natural products from marine organisms and their associated microbes. Chembiochem 7(2):229–238CrossRefGoogle Scholar
  34. Krings M, Taylor TN, Hass H, Kerp H, Dotzler N, Hermsen EJ (2007) Fungal endophytes in a 400-million-yr-old land plant: infection pathways, spatial distribution, and host responses. New Phytol 174(3):648–657CrossRefGoogle Scholar
  35. Larran S, Simón MR, Moreno MV, Siurana MS, Perelló A (2016) Endophytes from wheat as biocontrol agents against tan spot disease. Biol Control 92:17–23CrossRefGoogle Scholar
  36. Li HL, Li XM, Liu H, Meng LH, Wang BG (2016) Two new diphenylketones and a new xanthone from Talaromyces islandicus EN-501, an endophytic fungus derived from the marine red alga Laurencia okamurai. Mar Drugs 14(12):223CrossRefGoogle Scholar
  37. Li HL, Li XM, Li X, Wang CY, Liu H, Kassack MU, Meng LH, Wang BG (2017) Antioxidant Hydroanthraquinones from the marine algal-derived endophytic fungus Talaromyces islandicus EN-501. J Nat Prod 80(1):162–168CrossRefGoogle Scholar
  38. Liang XR, Miao FP, Song YP, Guo ZY, Ji NY (2016) Trichocitrin, a new fusicoccane diterpene from the marine brown alga-endophytic fungus Trichoderma citrinoviride cf-27. Nat Prod Res 30(14):1605–1610CrossRefGoogle Scholar
  39. Liu H, Li XM, Liu Y, Zhang P, Wang JN, Wang BG (2016) Chermesins A–D: meroterpenoids with a drimane-type spirosesquiterpene skeleton from the marine algal-derived endophytic fungus Penicillium chermesinum EN-480. J Nat Prod 79(4):806–811CrossRefGoogle Scholar
  40. Llorens A, Mateo R, Hinojo MJ, Logrieco A, Jimenez M (2004) Influence of the interactions among ecological variables in the characterization of zearalenone producing isolates of Fusarium spp. Syst Appl Microbiol 27(2):253–260CrossRefGoogle Scholar
  41. Lösgen S, Schlörke O, Meindl K, Herbst-Irmer R, Zeeck A (2007) Structure and biosynthesis of chaetocyclinones, new polyketides produced by an endosymbiotic fungus. Eur J Org Chem 2007(13):2191–2196CrossRefGoogle Scholar
  42. Mani VM, Soundari APG, Karthiyaini D, Preeth K (2015) Bioprospecting endophytic fungi and their metabolites from medicinal tree Aegle marmelos in Western Ghats, India. Mycobiology 43(3):303–310CrossRefGoogle Scholar
  43. Mathan S, Subramanian V, Nagamony S (2013) Optimization and antimicrobial metabolite production from endophytic fungi Aspergillus terreus KC 582297. Eur J Exp Biol 3:138–144Google Scholar
  44. Miao LI, Kwong TF, Qian PY (2006) Effect of culture conditions on mycelial growth, antibacterial activity, and metabolite profiles of the marine-derived fungus Arthrinium cf saccharicola. Appl Microbiol Biotechnol 72(5):1063–1073CrossRefGoogle Scholar
  45. Mohamed S, Hashim SN, Rahman HA (2012) Seaweeds: a sustainable functional food for complementary and alternative therapy. Trends Food Sci Technol 23(2):83–96CrossRefGoogle Scholar
  46. Mouritsen OG (2013) Seaweeds: edible, available, and sustainable. University of Chicago Press, LondonCrossRefGoogle Scholar
  47. Newman DJ, Hill RT (2006) New drugs from marine microbes: the tide is turning. J Ind Microbiol Biotechnol 33(7):539–544CrossRefGoogle Scholar
  48. Oh DC, Jensen PR, Fenical W (2006) Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii. Tetrahedron Lett 47(48):8625–8628CrossRefGoogle Scholar
  49. Ohkawa Y, Miki K, Suzuki T, Nishio K, Sugita T, Kinoshita K, Takahashi K, Koyama K (2010) Antiangiogenic metabolites from a marine-derived fungus, Hypocrea vinosa. J Nat Prod 73(4):579–582CrossRefGoogle Scholar
  50. Omacini M, Chaneton EJ, Ghersa CM, Muller CB (2001) Symbiotic fungal endophytes control insect host-parasite interaction webs. Nature 409(6816):78CrossRefGoogle Scholar
  51. Osterhage C, Kaminsky R, König GM, Wright AD (2000) Ascosalipyrrolidinone a, an antimicrobial alkaloid, from the obligate marine fungus Ascochyta s alicorniae. J Org Chem 65(20):6412–6417CrossRefGoogle Scholar
  52. Petrini O (1986) Taxonomy of endophytic fungi of aerial plant tissues. Fokkema NJ, van den Huevel J Microbiology of the phyllosphere, Cambridge University Press, Cambridge, 175–187Google Scholar
  53. Pettit RK (2011) Small-molecule elicitation of microbial secondary metabolites. Microb Biotechnol 4(4):471–478CrossRefGoogle Scholar
  54. Pontius A, Krick A, Mesry R, Kehraus S, Foegen SE, Müller M, Klimo K, Gerhäuser C, König GM (2008) Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. J Nat Prod 71(11):1793–1799CrossRefGoogle Scholar
  55. Redecker D, Morton JB, Bruns TD (2000) Ancestral lineages of arbuscular mycorrhizal fungi (Glomales). Mol Phylogenet Evol 14(2):276–284CrossRefGoogle Scholar
  56. Santoyo G, Moreno-Hagelsieb G, del Carmen Orozco-Mosqueda M, Glick BR (2016) Plant growth-promoting bacterial endophytes. Microbiol Res 183:92–99CrossRefGoogle Scholar
  57. Sarasan M, Puthumana J, Job N, Han J, Lee JS, Philip R (2017) Marine algicolous endophytic fungi-A promising drug resource of the era. J Microbiol Biotechnol 27:1039PubMedGoogle Scholar
  58. Singh RP, Kumari P, Reddy CRK (2015) Antimicrobial compounds from seaweeds-associated bacteria and fungi. Appl Microbiol Biotechnol 99(4):1571–1586CrossRefGoogle Scholar
  59. Stone JK, Bacon CW, White JF (2000) An overview of endophytic microbes: endophytism defined. Microb Endophytes 3:29–33Google Scholar
  60. Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67(4):491–502CrossRefGoogle Scholar
  61. Sun HF, Li XM, Meng L, Cui CM, Gao SS, Li CS, Huang CG, Wang BG (2012) Asperolides A–C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48. J Nat Prod 75(2):148–152CrossRefGoogle Scholar
  62. Suryanarayanan TS, Venkatachalam A, Thirunavukkarasu N, Ravishankar JP, Doble M, Geetha V (2010) Internal mycobiota of marine macroalgae from the Tamilnadu coast: distribution, diversity and biotechnological potential. Bot Mar 53(5):457–468CrossRefGoogle Scholar
  63. Tsuda M, Kasai Y, Komatsu K, Sone T, Tanaka M, Mikami Y, Kobayashi JI (2004) Citrinadin A, a novel pentacyclic alkaloid from marine-derived fungus Penicillium citrinum. Org Lett 6(18):3087–3089CrossRefGoogle Scholar
  64. Wang S, Li XM, Teuscher F, Li DL, Diesel A, Ebel R, Proksch P, Wang BG (2006) Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata. J Nat Prod 69(11):1622–1625CrossRefGoogle Scholar
  65. Wilson D (1995) Endophyte: the evolution of a term, and clarification of its use and definition. Oikos:274–276Google Scholar
  66. Zhang HW, Song YC, Tan RX (2006) Biology and chemistry of endophytes. Nat Prod Rep 23(5):753–771CrossRefGoogle Scholar
  67. Zhang Y, Li XM, Wang CY, Wang BG (2007) A new naphthoquinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13. Chin Chem Lett 18(8):951–953CrossRefGoogle Scholar
  68. Zhang P, Mandi A, Li XM, Du FY, Wang JN, Li X, Kurtan T, Wang BG (2014) Varioxepine A, a 3 H-oxepine-containing alkaloid with a new oxa-cage from the marine algal-derived endophytic fungus Paecilomyces variotii. Org Lett 16(18):4834–4837CrossRefGoogle Scholar
  69. Zhang P, Li XM, Wang JN, Li X, Wang BG (2015a) New butenolide derivatives from the marine-derived fungus Paecilomyces variotii with DPPH radical scavenging activity. Phytochem Lett 11:85–88CrossRefGoogle Scholar
  70. Zhang P, Li XM, Wang JN, Li X, Wang BG (2015b) Prenylated indole alkaloids from the marine-derived fungus Paecilomyces variotii. Chin Chem Lett 26(3):313–316CrossRefGoogle Scholar
  71. Zhang P, Li X, Wang BG (2016a) Secondary metabolites from the marine algal-derived endophytic fungi: chemical diversity and biological activity. Planta Med 82(09/10):832–842CrossRefGoogle Scholar
  72. Zhang P, Li XM, Mao XX, Mándi A, Kurtán T, Wang BG (2016b) Varioloid A, a new indolyl-6, 10b-dihydro-5aH-[1] benzofuro [2, 3-b] indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291. Beilstein J Org Chem 12:2012CrossRefGoogle Scholar
  73. Zhu TJ, Du, Hao PF, Lin ZJ, Gu QQ (2009) Citrinal A, a novel tricyclic derivative of citrinin, from an algicolous fungus Penicillium sp. i-1-1. Chin Chem Lett 20(8):917–920CrossRefGoogle Scholar
  74. Zuccaro A, Mitchell JI (2005) Fungal communities of seaweeds. In: Digton J, White JF, Oudemans P (eds) The fungal community: its organization and role in the ecosystem. Mycology Series, vol 23, 3rd edn. CRC Press, New York, pp 533–579CrossRefGoogle Scholar
  75. Zuccaro A, Schulz B, Mitchell JI (2003) Molecular detection of ascomycetes associated with Fucus serratus. Mycol Res 107(12):1451–1466CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Vipin Kumar Singh
    • 1
  • Abhishek Kumar Dwivedy
    • 1
  • Akanksha Singh
    • 1
  • Simran Asawa
    • 2
  • Awanindra Dwivedi
    • 3
  • Nawal Kishore Dubey
    • 1
  1. 1.Centre of Advanced Study in Botany, Institute of ScienceBanaras Hindu UniversityVaranasiIndia
  2. 2.Department of BiotechnologyNational Institute of TechnologyWarangalIndia
  3. 3.National Centre for Disease ControlDelhiIndia

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