Membrane Receptors and Signal Transduction Pathway



For a unicellular and multicellular organism to function properly it is paramount that its cell to cell communication happens unhindered. This communication may take by direct physical contact between cell, or indirectly by secreting specific molecules as messenger from one cell, that transmit signal by binding and activating receptors at the surface or inside the other cells. The signal received by membrane receptor may be hormone, photons, protons (H+), ions (Ca2+), neurotransmitters, foreign antigen, peptides and lipids. The ligand induced change in conformation of receptor may interact with effector molecules and releases various second messenger to pass signal from membrane to nucleus like Inositol 1,4,5-triphosphate, cAMP, cGMP, diacylglycerol and arachidonic acids. The role of various ligand ,receptors and mechanism of transport has been discussed in this chapter.


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of BiochemistryShivaji CollegeNew DelhiIndia
  2. 2.Department of BiochemistryDaulat Ram College, University of DelhiNew DelhiIndia

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