Singer and Nicolson’s fluid mosaic model formed the basis of dynamic nature of cellular membranes. Molecules in membranes, the lipids, and proteins are in a state of dynamic motion which includes bond-bending, bond-stretching, lateral diffusion, rotation and flip-flop motion. Developments of new fluorescent labeling and imaging techniques have helped in the study of membrane dynamics. In biological membranes, molecular motion is rather restricted as compared to in synthetic liposomes. This is due to many physical barriers present in membranes, which includes the cytoskeleton, membrane–membrane junctions, intramembrane clusters. The RBC membrane provides a perfect example to study the impact of membrane barriers on molecular motion. A fluid membrane is essential for a functional membrane required for survival of a cell. Hence, in microorganisms, plants, poikilotherms, and hibernating animal’s homeoviscous adaptations maintain optimal membrane fluidity for cell survival.
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