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New Targeted Approach to CRPC

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Hormone Therapy and Castration Resistance of Prostate Cancer

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Abstract

Our understanding of the heterogeneity and genetic characteristics of CRPC demonstrates underlying their complexity, which has been thought to be associated with their intractability. Recent advance of integrative next generation sequencing unveiled the extensive mutational landscape of metastatic CRPC, many of which can be a targetable mutation and been linked to ongoing clinical trials. Molecular stratification of patient groups will clearly be critical to successful drug development and clinical trials from the view point of precision medicine. In this review, we discuss the potential of new targeted approach to impact the clinical management of CRPC.

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Author information

Authors and Affiliations

  1. Department of Urology, Keio University School of Medicine, Tokyo, Japan

    Takeo Kosaka M.D., Ph.D. & Mototsugu Oya

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  1. Takeo Kosaka M.D., Ph.D.
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  2. Mototsugu Oya
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Editors and Affiliations

  1. Department of Urology, Tohoku University School of Medicine, Sendai, Japan

    Yoichi Arai

  2. Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Osamu Ogawa

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Kosaka, T., Oya, M. (2018). New Targeted Approach to CRPC. In: Arai, Y., Ogawa, O. (eds) Hormone Therapy and Castration Resistance of Prostate Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-10-7013-6_38

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  • DOI: https://doi.org/10.1007/978-981-10-7013-6_38

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