Abstract
Although 75 mg/m2 docetaxel (DTX) with 10 mg prednisolone regimen is a gold standard of the first-line chemotherapy for patients with metastatic castration-resistant prostate cancer (mCRPC), optimal number of the cycles remains controversial. Most guidelines recommend DTX regimen should be terminated up to 10 cycles, but the optimal number is controversial. We retrospectively analyzed 279 CRPC patients who received DTX regimen. Patients having more than 10 cycles of DTX had significantly better overall survival (OS) than those having 10 or less, and prediction model of optimal number of cycles in DTX regimen was constructed based on the risk table employing the combination of three factors (ALP [cutoff 189 IU/L], hemoglobin [11.3 g/dL], and age [65 years] at the start of DTX therapy), and scoring based on the hazard ratio of each risk factor (ALP 4, hemoglobin 2, age 3). The prediction model could effectively predict the probability of the length of DTX therapy, with the c-index of 0.7274. Since the new drugs are clinically available, optimal number of cycles should be determined based on the PS, toxicities, or patients’ wish. Our predicting model may help in patients’ consultation before starting DTX regimen, or in selecting potential patients with intolerant DTX regimen.
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Matsuyama, H. et al. (2018). Prediction of Optimal Number of Cycles in Docetaxel Regimen for Patients with mCRPC. In: Arai, Y., Ogawa, O. (eds) Hormone Therapy and Castration Resistance of Prostate Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-10-7013-6_35
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DOI: https://doi.org/10.1007/978-981-10-7013-6_35
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