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Detection of Circulating Tumor Cells in Castration-Resistant Prostate Cancer

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Book cover Hormone Therapy and Castration Resistance of Prostate Cancer

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Abstract

Metastasis from primary tumors is responsible for most cancer deaths. Several reports have suggested that early-stage cancer has the potential to begin shedding cancer cells into the circulation early in development. Several groups have noted that levels of circulating tumor cells (CTCs) in patients parallel the tumor burden and response to therapy. There are multiple approaches to detecting CTCs. CTCs at baseline are a strong, independent prognostic biomarker. In addition, measuring CTCs at any time point predicts the response to therapy. The goal of the present chapter is to provide an update on the advances in the clinical validation of CTCs as a surrogate biomarker in prostate cancer patients.

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Author information

Authors and Affiliations

  1. Department of Urology, The University of Kyorin, Tokyo, Japan

    Takatsugu Okegawa M.D.

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  1. Takatsugu Okegawa M.D.
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Correspondence to Takatsugu Okegawa M.D. .

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Editors and Affiliations

  1. Department of Urology, Tohoku University School of Medicine, Sendai, Japan

    Yoichi Arai

  2. Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Osamu Ogawa

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Okegawa, T. (2018). Detection of Circulating Tumor Cells in Castration-Resistant Prostate Cancer. In: Arai, Y., Ogawa, O. (eds) Hormone Therapy and Castration Resistance of Prostate Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-10-7013-6_30

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  • DOI: https://doi.org/10.1007/978-981-10-7013-6_30

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7012-9

  • Online ISBN: 978-981-10-7013-6

  • eBook Packages: MedicineMedicine (R0)

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