Abstract
The conventional food-engineering equipments such as evaporators, drier, extruders have been identified to have major applications in developing food-grade nanoemulsions. These engineering aspects also helped industrialists to scale-up the laboratory scale formulation to the industrial scale via pilot-plat scale. Nanoencapsulation can be defined as a process to pack active compound using miniature making techniques such as nanoemulsification, nanocomposite, and nanoestructuration. It will maintain the product functionability during storage and also may lead to targeted delivery and controlled release of the core i.e. active compound encapsulated. Here in this review, (i) The food engineering aspects for developing food-grade nanoemulsions have been discussed; (ii) The major advantages, important changes required and other challenges have been discussed (iii) possibilities of developing food-grade nanoemulsions from lab-scale formulations have been discussed.
References
Abdelwahed W, Degobert G, Fessi H (2006) A pilot study of freeze drying of poly (epsilon-caprolactone) nanocapsules stabilized by poly (vinyl alcohol): formulation and process optimization. Int J Pharm 309:178–188
Akl MA, Kartal-Hodzic A, Oksanen T et al (2016) Factorial design formulation optimization and in vitro characterization of curcumin-loaded PLGA nanoparticles for colon delivery. J Drug Deliv Sci Technol 32:10–20. https://doi.org/10.1016/j.jddst.2016.01.007
Anandharamakrishnan C (2014a) Liquid-based nanoencapsulation techniques. In: Techniques for nanoencapsulation of food ingredients. Springer, Berlin, pp 29–41
Anandharamakrishnan C (2014b) Electrospraying and electrospinning techniques for nanoencapsulation. In: Techniques for nanoencapsulation of food ingredients. Springer, Berlin, pp 43–49
Anandharamakrishnan C (2014c) Techniques for nanoencapsulation of food ingredients. Springer, New York
Anarjan N, Mirhosseini H, Baharin BS, Tan CP (2011) Effect of processing conditions on physicochemical properties of sodium caseinate-stabilized astaxanthin nanodispersions. LWT Food Sci Technol 44:1658–1665. https://doi.org/10.1016/j.lwt.2011.01.013
Anitha A, Maya S, Deepa N et al (2011a) Efficient water soluble O-carboxymethyl chitosan nanocarrier for the delivery of curcumin to cancer cells. Carbohydr Polym 83:452–461
Anitha A, Maya S, Deepa N et al (2011b) Curcumin-loaded N,O-Carboxymethyl chitosan nanoparticles for cancer drug delivery. J Biomater Sci Polym Ed:37–41. https://doi.org/10.1163/092050611X581534
Anitha A, Maya S, Deepa N et al (2012) Curcumin-loaded N, O- Carboxymethyl chitosan nanoparticles for cancer drug delivery. J Biomater Sci Polym Ed 5063:37–41. https://doi.org/10.1163/092050611X581534
Aree T, Jongrungruangchok S (2016) Crystallographic evidence for β-cyclodextrin inclusion complexation facilitating the improvement of antioxidant activity of tea (+)-catechin and (−)-epicatechin. Carbohydr Polym 140:362–373
Arya N, Chakraborty S, Dube N, Katti DS (2009) Electrospraying: a facile technique for synthesis of chitosan-based micro/nanospheres for drug delivery applications. J Biomed Mater Res Part B Appl Biomater 88:17–31
Bacinello D, Garanger E, Taton D et al (2015) Tailored drug-release from multi-functional polymer-peptide hybrid vesicles. Eur Polym J 62:363–373. https://doi.org/10.1016/j.eurpolymj.2014.09.001
Bai L, McClements DJ (2016) Development of microfluidization methods for efficient production of concentrated nanoemulsions: comparison of single-and dual-channel microfluidizers. J Colloid Interface Sci 466:206–212
Bejrapha P, Min S-G, Surassmo S, Choi M-J (2010) Physicothermal properties of freeze-dried fish oil Nanocapsules frozen under different conditions. Dry Technol 28:481–489. https://doi.org/10.1080/07373931003613684
Bejrapha P, Surassmo S, Choi M-J et al (2011) Studies on the role of gelatin as a cryo-and lyo-protectant in the stability of capsicum oleoresin nanocapsules in gelatin matrix. J Food Eng 105:320–331
Brahatheeswaran D, Mathew A, Aswathy RG et al (2012) Hybrid fluorescent curcumin loaded zein electrospun nanofibrous scaffold for biomedical applications. Biomed Mater 7:45001. https://doi.org/10.1088/1748-6041/7/4/045001
Brown S (2016) Pharmaceutical composition comprising nanocrystals
Calligaris S, Plazzotta S, Bot F et al (2016) Nanoemulsion preparation by combining high pressure homogenization and high power ultrasound at low energy densities. Food Res Int 83:25–30
Campardelli R, Reverchon E (2015) α-tocopherol nanosuspensions produced using a supercritical assisted process. J Food Eng 149:131–136. https://doi.org/10.1016/j.jfoodeng.2014.10.015
Cauteruccio S, Bartoli C, Carrara C et al (2015) A nanostructured PLGA system for cell delivery of a Tetrathiahelicene as a model for helical DNA Intercalators. Chem Plus Chem 80:490–493
Cavallaro G, Craparo EF, Sardo C et al (2015) PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions. Int J Pharm 495:719–727. https://doi.org/10.1016/j.ijpharm.2015.09.050
Chandra Bhatt P, Srivastava P, Pandey P et al (2016) Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies. RSC Adv 6:10001–10010. https://doi.org/10.1039/C5RA19113K
Chen M-J (2007) Development and parametric studies of carbon nanotube dispersion using electrospraying
Chen C, Yang W, Wang DT et al (2014) A modified spontaneous emulsification solvent diffusion method for the preparation of curcumin-loaded PLGA nanoparticles with enhanced in vitro anti-tumor activity. Front Mater Sci 8:332–342. https://doi.org/10.1007/s11706-014-0268-2
Cheong JN, Tan CP, Man YBC, Misran M (2008) α-tocopherol nanodispersions: preparation, characterization and stability evaluation. J Food Eng 89:204–209. https://doi.org/10.1016/j.jfoodeng.2008.04.018
Chidambaram M, Krishnasamy K (2014) Modifications to the conventional nanoprecipitation technique: an approach to fabricate narrow sized polymeric nanoparticles. Adv Pharm Bull 4:205–208. https://doi.org/10.5681/apb.2014.030
Choi MJ, Ruktanonchai U, Min SG et al (2010) Physical characteristics of fi sh oil encapsulated by ß-cyclodextrin using an aggregation method or polycaprolactone using an emulsion-diffusion method. Food Chem 119:1694–1703. https://doi.org/10.1016/j.foodchem.2009.09.052
Chow SF, Wan KY, Cheng KK et al (2015) Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization. Eur J Pharm Biopharm 94:436–449. https://doi.org/10.1016/j.ejpb.2015.06.022
Danie Kingsley J, Ranjan S, Dasgupta N, Saha P (2013) Nanotechnology for tissue engineering: need, techniques and applications. J Pharm Res 7:200–204. https://doi.org/10.1016/j.jopr.2013.02.021
de Paz E, Martin A, Mateos E, Cocero MJ (2014) Production of water-soluble β-carotene micellar formulations by novel emulsion techniques. Chem Eng Process Process Intensif 74:90–96. https://doi.org/10.1016/j.cep.2013.09.004
Delgado-Zamarreño MM, Fernández-Prieto C, Bustamante-Rangel M, Pérez-Martín L (2016) Determination of tocopherols and sitosterols in seeds and nuts by QuEChERS-liquid chromatography. Food Chem 192:825–830
Dong B, Smith ME, Wnek GE (2009) Encapsulation of multiple biological compounds within a single electrospun fiber. Small 5:1508–1512. https://doi.org/10.1002/smll.200801750
Drosou CG, Krokida MK, Biliaderis CG (2016) Encapsulation of bioactive compounds through electrospinning/electrospraying and spray drying: a comparative assessment of food related applications. Dry Technol 35:139–162
Duarte ARC, Mano JF, Reis RL (2015) Polymer processing using supercritical fluid based technologies for drug delivery and tissue engineering applications. In: Supercritical fluid nanotechnology, pp 273–288. https://doi.org/10.1201/b19242-13
Dube A, Ng K, Nicolazzo JA, Larson I (2010) Effective use of reducing agents and nanoparticle encapsulation in stabilizing catechins in alkaline solution. Food Chem 122:662–667. https://doi.org/10.1016/j.foodchem.2010.03.027
Ezhilarasi PN, Karthik P, Chhanwal N, Anandharamakrishnan C (2013) Nanoencapsulation techniques for food bioactive components: a review. Food Bioprocess Technol 6:628–647
Fernandez A, Torres-Giner S, Lagaron JM (2009) Novel route to stabilization of bioactive antioxidants by encapsulation in electrospun fibers of zein prolamine. Food Hydrocoll 23:1427–1432. https://doi.org/10.1016/j.foodhyd.2008.10.011
Ferreira I, Rocha S, Coelho M (2007) Encapsulation of antioxidants by spray-drying. Chem Eng Trans 11:713–717
Fisk ID, Linforth R, Trophardy G, Gray D (2013) Entrapment of a volatile lipophilic aroma compound (d-limonene) in spray dried water-washed oil bodies naturally derived from sunflower seeds (Helianthus Annus). Food Res Int 54:861–866. https://doi.org/10.1016/j.foodres.2013.08.024
Fornaguera C, Dols-Perez A, Caldero G et al (2015) PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood-brain barrier. J Control Release 211:134–143. https://doi.org/10.1016/j.jconrel.2015.06.002
Frank LA, Contri RV, Beck RCR et al (2015) Improving drug biological effects by encapsulation into polymeric nanocapsules. Wiley Interdiscip Rev Nanomed NanoBiotechnol 7:623–639
Fung WY (2015) Electrospinning and Electrospraying: production of nanofibers and microparticles for nutraceutical/pharmaceutical applications. Universiti Sains Malaysia, Penang
Gadkari PV, Balaraman M (2015) Catechins: sources, extraction and encapsulation: a review. Food Bioprod Process 93:122–138. https://doi.org/10.1016/j.fbp.2013.12.004
Ghaderi S, Ghanbarzadeh S, Hamishehkar H (2015) Evaluation of different methods for preparing nanoparticle containing gammaoryzanol for potential use in food fortification. Pharm Sci 20:130
Ghorani B, Tucker N (2015) Fundamentals of electrospinning as a novel delivery vehicle for bioactive compounds in food nanotechnology. Food Hydrocoll 51:227–240
Gomez-Estaca J, Balaguer MP, Gavara R, Hernandez-Munoz P (2012) Formation of zein nanoparticles by electrohydrodynamic atomization: effect of the main processing variables and suitability for encapsulating the food coloring and active ingredient curcumin. Food Hydrocoll 28:82–91. https://doi.org/10.1016/j.foodhyd.2011.11.013
Gómez-Estaca J, Gavara R, Hernández-Muñoz P (2015) Encapsulation of curcumin in electrosprayed gelatin microspheres enhances its bioaccessibility and widens its uses in food applications. Innov Food Sci Emerg Technol 29:302–307. https://doi.org/10.1016/j.ifset.2015.03.004
Gou M, Men K, Shi H et al (2011) Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale 3:1558–1567. https://doi.org/10.1039/c0nr00758g
Ha H-K, Jeon N-E, Kim JW et al (2016) Physicochemical characterization and potential prebiotic effect of whey protein isolate/inulin Nano complex. Korean J Food Sci Anim Resour 36:267
Hădărugă NG, Hădărugă DI, Păunescu V et al (2006) Thermal stability of the linoleic acid/α- and β-cyclodextrin complexes original research article. Food Chem 99:500–508
Hategekimana J, Masamba KG, Ma J, Zhong F (2015) Encapsulation of vitamin E: effect of physicochemical properties of wall material on retention and stability. Carbohydr Polym 124:172–179
Hebbalalu D, Lalley J, Nadagouda MN, Varma RS (2013) Greener techniques for the synthesis of silver nanoparticles using plant extracts, enzymes, bacteria, biodegradable polymers, and microwaves. ACS Sustain Chem Eng 1:703–712
Hélder DS, Cerqueira MA, Souza BWS et al (2011) Nanoemulsions of β-carotene using a high-energy emulsification- evaporation technique. J Food Eng 102:130–135. https://doi.org/10.1016/j.jfoodeng.2010.08.005
Hosseini SF, Zandi M, Rezaei M, Farahmandghavi F (2013) Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study. Carbohydr Polym 95:50–56. https://doi.org/10.1016/j.carbpol.2013.02.031
Hosseini SMH, Emam-Djomeh Z, Sabatino P, Van der Meeren P (2015) Nanocomplexes arising from protein-polysaccharide electrostatic interaction as a promising carrier for nutraceutical compounds. Food Hydrocoll 50:16–26. https://doi.org/10.1016/j.foodhyd.2015.04.006
Ishwarya SP, Anandharamakrishnan C, Stapley AGF (2015) Spray-freeze-drying: a novel process for the drying of foods and bioproducts. Trends Food Sci Technol 41:161–181
Jafari SM, He Y, Bhandari B (2007) Encapsulation of nanoparticles of d-limonene by spray drying: role of emulsifiers and emulsifying techniques. Dry Technol 25:1069–1079. https://doi.org/10.1080/07373930701396758
Jafari SM, Assadpoor E, Bhandari B, He Y (2008) Nano-particle encapsulation of fish oil by spray drying. Food Res Int 41:172–183. https://doi.org/10.1016/j.foodres.2007.11.002
Jaworek A, Sobczyk AT (2008) Electrospraying route to nanotechnology: an overview. J Electrost 66:197–219. https://doi.org/10.1016/j.elstat.2007.10.001
Jayaraman P, Gandhimathi C, Venugopal JR et al (2015) Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering. Adv Drug Deliv Rev 94:77–95
Jin H, XIA F, Jiang C et al (2009) Nanoencapsulation of lutein with Hydroxypropylmethyl cellulose phthalate by supercritical Antisolvent. Chinese. J Chem Eng 17:672–677. https://doi.org/10.1016/S1004-9541(08)60262-1
Jincheng W, Xiaoyu Z, Sihao C (2010) Preparation and properties of Nanocapsulated capsaicin by complex Coacervation method. Chem Eng Commun 197:919–933. https://doi.org/10.1080/00986440903249700
Kailasapathy K (2015) Biopolymers for administration and gastrointestinal delivery of functional food ingredients and probiotic bacteria. Funct Polym Food Sci Technol Biol 2:231–259
Karoyo A, Wilson L (2015) Nano-sized Cyclodextrin-based molecularly imprinted polymer adsorbents for Perfluorinated compounds—a mini-review. Nanomaterials 5:981–1003. https://doi.org/10.3390/nano5020981
Kayaci F, Uyar T (2012a) Encapsulation of vanillin/cyclodextrin inclusion complex in electrospun polyvinyl alcohol (PVA) nanowebs: prolonged shelf-life and high temperature stability of vanillin. Food Chem 133:641–649
Kayaci F, Uyar T (2012b) Encapsulation of vanillin/cyclodextrin inclusion complexes in electrospun nanowebs: High-temperature stability and slow release of vanillin. In: Fiber Society 2012 Spring Conference: Fiber Research for Tomorrow’s Applications
Khalil NM, do NTCF, Casa DM et al (2013) Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats. Colloids Surf B Biointerfaces 101:353–360. https://doi.org/10.1016/j.colsurfb.2012.06.024
Khayata N, Abdelwahed W, Chehna MF et al (2012a) Preparation of vitamin e loaded nanocapsules by the nanoprecipitation method: from laboratory scale to large scale using a membrane contactor. Int J Pharm 423:419–427. https://doi.org/10.1016/j.ijpharm.2011.12.016
Khayata N, Abdelwahed W, Chehna MF et al (2012b) Stability study and lyophilization of vitamin E-loaded nanocapsules prepared by membrane contactor. Int J Pharm 439:254–259. https://doi.org/10.1016/j.ijpharm.2012.09.032
Klippstein R, Wang JTW, El-Gogary RI et al (2015) Passively targeted curcumin-loaded PEGylated PLGA nanocapsules for colon cancer therapy in vivo. Small 11:4704–4722. https://doi.org/10.1002/smll.201403799
Kotta S, Khan AW, Ansari SH, et al (2015) Formulation of nanoemulsion: a comparison between phase inversion composition method and high-pressure homogenization method. Drug Deliv 22:455–466
Kumari A, Yadav SK, Pakade YB et al (2010a) Development of biodegradable nanoparticles for delivery of quercetin. Colloids Surf B Biointerfaces 80:184–192. https://doi.org/10.1016/j.colsurfb.2010.06.002
Kumari A, Yadav SK, Yadav SC (2010b) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 75:1–18
Kumari A, Yadav SK, Pakade YB et al (2011) Nanoencapsulation and characterization of Albizia Chinensis isolated antioxidant quercitrin on PLA nanoparticles. Colloids Surf B Biointerfaces 82:224–232. https://doi.org/10.1016/j.colsurfb.2010.08.046
Leong WF, Che Man YB, Lai OM et al (2011a) Effect of sucrose fatty acid esters on the particle characteristics and flow properties of phytosterol nanodispersions. J Food Eng 104:63–69. https://doi.org/10.1016/j.jfoodeng.2010.11.028
Leong WF, Lai OM, Long K et al (2011b) Preparation and characterisation of water-soluble phytosterol nanodispersions. Food Chem 129:77–83. https://doi.org/10.1016/j.foodchem.2011.04.027
Li J, Lee IW, Shin GH et al (2015a) Curcumin-Eudragit® e PO solid dispersion: a simple and potent method to solve the problems of curcumin. Eur J Pharm Biopharm 94:322–332. https://doi.org/10.1016/j.ejpb.2015.06.002
Li H, Yan K, Shang Y et al (2015b) Folate-bovine serum albumin functionalized polymeric micelles loaded with superparamagnetic iron oxide nanoparticles for tumor targeting and magnetic resonance imaging. Acta Biomater 15:117–126
Liang R, Huang Q, Ma J et al (2013) Effect of relative humidity on the store stability of spray-dried beta-carotene nanoemulsions. Food Hydrocoll 33:225–233
Lim L-T (2015) Encapsulation of bioactive compounds using electrospinning and electrospraying technologies. In: Nanotechnology and functional foods, pp 297–317. https://doi.org/ 10.1002/9781118462157.ch18
Lira MCB, Ferraz MS, da Silva DGVC et al (2009) Inclusion complex of usnic acid with β-cyclodextrin: characterization and nanoencapsulation into liposomes. J Incl Phenom Macrocycl Chem 64:215–224
Liu J, Xu L, Liu C et al (2012) Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake. Carbohydr Polym 90:16–22. https://doi.org/10.1016/j.carbpol.2012.04.036
Lomova MV, Brichkina AI, Kiryukhin MV et al (2015) Multilayer capsules of bovine serum albumin and tannic acid for controlled release by enzymatic degradation. ACS Appl Mater Interfaces 7:11732–11740
López-Rubio A, Lagaron JM (2012) Whey protein capsules obtained through electrospraying for the encapsulation of bioactives. Innov Food Sci Emerg Technol 13:200–206. https://doi.org/10.1016/j.ifset.2011.10.012
López-Rubio A, Sanchez E, Sanz Y, Lagaron JM (2009) Encapsulation of living bifidobacteria in ultrathin PVOH electrospun fibers. Biomacromolecules 10:2823–2829. https://doi.org/10.1021/bm900660b
Luo Y, Teng Z, Wang Q (2012) Development of zein nanoparticles coated with carboxymethyl chitosan for encapsulation and controlled release of vitamin D3. J Agric Food Chem 60:836–843. https://doi.org/10.1021/jf204194z
Mahalingam M, Krishnamoorthy K (2015) Fabrication and optimization of camptothecin loaded Eudragit S 100 nanoparticles by Taguchi L4 orthogonal array design. Int J Pharm Investig 5:147
Majeed H, Bian Y-Y, Ali B et al (2015) Essential oil encapsulations: uses, procedures, and trends. RSC Adv 5:58449–58463
Martín Á, de Paz E, Mattea F, Coceroa MJ (2015) Preparation of water-soluble formulations of hydrophobic active compounds by emulsion template processes. Supercrit Fluid Nanotechnol Adv Appl Compos Hybrid Nanomater 159. https://doi.org/10.1201/b19242-9
Moghaddam MK, Mortazavi SM, Khayamian T (2015a) Preparation of calcium alginate microcapsules containing n-nonadecane by a melt coaxial electrospray method. J Electrost 73:56–64. https://doi.org/10.1016/j.elstat.2014.10.013
Moghaddam MK, Mortazavi SM, Khaymian T (2015b) Micro/nano-encapsulation of a phase change material by coaxial electrospray method. Iran Polym J 24:759–774
Mukerjee A, Vishwanatha JK (2009) Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 29:3867–3875. doi: 29/10/3867 [pii]
Murugesan R, Orsat V (2012) Spray drying for the production of nutraceutical ingredients – a review. Food Bioprocess Technol 5:3–14
Nakagawa K, Nagao H (2012) Microencapsulation of oil droplets using freezing-induced gelatin-acacia complex coacervation. Colloids Surf Physicochem Eng ASp 411:129–139. https://doi.org/10.1016/j.colsurfa.2012.07.010
Nandiyanto ABD, Okuyama K (2011) Progress in developing spray-drying methods for the production of controlled morphology particles: from the nanometer to submicrometer size ranges. Adv Powder Technol 22:1–19
Paramita V, Furuta T, Yoshii H (2012) High-oil-load encapsulation of medium-chain triglycerides and d-limonene mixture in modified starch by spray drying. J Food Sci. https://doi.org/10.1111/j.1750-3841.2011.02534.x
Perez AA, Sponton OE, Andermatten RB et al (2015) Biopolymer nanoparticles designed for polyunsaturated fatty acid vehiculization: protein-polysaccharide ratio study. Food Chem 188:543–550. https://doi.org/10.1016/j.foodchem.2015.05.043
Quintanar-Guerrero D, Allémann E, Fessi H, Doelker E (1998) Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Dev Ind Pharm 24:1113–1128. https://doi.org/10.3109/03639049809108571
Rajendiran N, Sankaranarayanan RK, Saravanan J (2015) Nanochain and vesicles formed by inclusion complexation of 4, 4′-diaminobenzanilide with cyclodextrins. J Exp Nanosci 10:880–899
Rathore S, Desai PM, Liew CV et al (2013) Microencapsulation of microbial cells. J Food Eng 116:369–381
Rebolleda S, Sanz MT, Benito JM et al (2015) Formulation and characterisation of wheat bran oil-in-water nanoemulsions. Food Chem 167:16–23. https://doi.org/10.1016/j.foodchem.2014.06.097
Reverchon E, Adami R, Campardelli R et al (2015) Supercritical fluids based techniques to process pharmaceutical products difficult to micronize: Palmitoylethanolamide. J Supercrit Fluids 102:24–31. https://doi.org/10.1016/j.supflu.2015.04.005
Rey L (2016) Freeze-drying/lyophilization of pharmaceutical and biological products. CRC Press, Boca Raton
Ribeiro HS, Chu BS, Ichikawa S, Nakajima M (2008) Preparation of nanodispersions containing β-carotene by solvent displacement method. Food Hydrocoll 22:12–17. https://doi.org/10.1016/j.foodhyd.2007.04.009
Rodríguez-Meizoso I, Plaza M (2015) Particle formation of food ingredients by supercritical fluid technology. In: High pressure fluid technology for green food processing. Springer, Berlin, pp 155–183
Ron N, Zimet P, Bargarum J, Livney YD (2010) Beta-lactoglobulin--polysaccharide complexes as nanovehicles for hydrophobic nutraceuticals in non-fat foods and clear beverages. Int Dairy J 20:686–693
Sanoj Rejinold N, Muthunarayanan M, Divyarani VV, Sreerekha PR, Chennazhi KP (2011a) Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles for cancer drug delivery. J Colloid Interface Sci 360:39–51. https://doi.org/10.1016/j.jcis.2011.04.006
Sanoj Rejinold N, Sreerekha PR, Chennazhi KP et al (2011b) Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery. Int J Biol Macromol 49:161–172. https://doi.org/10.1016/j.ijbiomac.2011.04.008
Santana AA, Cano-Higuita DM, de Oliveira RA, Telis VRN (2016) Influence of different combinations of wall materials on the microencapsulation of jussara pulp (Euterpe Edulis) by spray drying. Food Chem 212:1–9
Scholz P, Keck CM (2015) Nanoemulsions produced by rotor-stator high speed stirring. Int J Pharm 482:110–117. https://doi.org/10.1016/j.ijpharm.2014.12.040
Shaikh J, Ankola DD, Beniwal V et al (2009) Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 37:223–230. https://doi.org/10.1016/j.ejps.2009.02.019
Sharma S, Sahni JK, Ali J, Baboota S (2015) Effect of high-pressure homogenization on formulation of TPGS loaded nanoemulsion of rutin–pharmacodynamic and antioxidant studies. Drug Deliv 22:541–551
Sill TJ, von Recum HA (2008) Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29:1989–2006
Sowasod N, Nakagawa K, Tanthapanichakoon W, Charinpanitkul T (2012) Development of encapsulation technique for curcumin loaded O/W emulsion using chitosan based cryotropic gelation. Mater Sci Eng C 32:790–798. https://doi.org/10.1016/j.msec.2012.01.027
Sun XZ, Williams GR, Hou XX, Zhu LM (2013) Electrospun curcumin-loaded fibers with potential biomedical applications. Carbohydr Polym 94:147–153. https://doi.org/10.1016/j.carbpol.2012.12.064
Surassmo S, Min SG, Bejrapha P, Choi MJ (2010) Effects of surfactants on the physical properties of capsicum oleoresin-loaded nanocapsules formulated through the emulsion-diffusion method. Food Res Int 43:8–17. https://doi.org/10.1016/j.foodres.2009.07.008
Surassmo S, Min S-G, Bejrapha P, Choi M-J (2011) Efficacy of capsicum oleoresin nanocapsules formulation by the modified emulsion-diffusion method. J Nanosci Nanotechnol 11:642–646. https://doi.org/10.1166/jnn.2011.3276
Suwannateep N, Banlunara W, Wanichwecharungruang SP et al (2011) Mucoadhesive curcumin nanospheres: biological activity, adhesion to stomach mucosa and release of curcumin into the circulation. J Control Release 151:176–182. https://doi.org/10.1016/j.jconrel.2011.01.011
Suwantong O, Opanasopit P, Ruktanonchai U, Supaphol P (2007) Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance. Polymer (Guildf) 48:7546–7557. https://doi.org/10.1016/j.polymer.2007.11.019
Suwantong O, Ruktanonchai U, Supaphol P (2008) Electrospun cellulose acetate fiber mats containing asiaticoside or Centella Asiatica crude extract and the release characteristics of asiaticoside. Polymer (Guildf) 49:4239–4247. https://doi.org/10.1016/j.polymer.2008.07.020
Suwantong O, Ruktanonchai U, Supaphol P (2010) In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin. J Biomed Mater ResPart A 94:1216–1225. https://doi.org/10.1002/jbm.a.32797
Torres-Giner S, Martinez-Abad A, Ocio MJ, Lagaron JM (2010) Stabilization of a nutraceutical omega-3 fatty acid by encapsulation in ultrathin electrosprayed zein prolamine. J Food Sci. https://doi.org/10.1111/j.1750-3841.2010.01678.x
Trinh N-T-T, Lejmi R, Gharsallaoui A et al (2015) Effect of emulsification and spray-drying microencapsulation on the antilisterial activity of transcinnamaldehyde. J Microencapsul 32:719–723. https://doi.org/10.3109/02652048.2015.1010460
Tsai YM, Jan WC, Chien CF et al (2011) Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats. Food Chem 127:918–925. https://doi.org/10.1016/j.foodchem.2011.01.059
Tsai Y-M, Chang-Liao W-L, Chien C-F et al (2012) Effects of polymer molecular weight on relative oral bioavailability of curcumin. Int J Nanomedicine 7:2957–2966. https://doi.org/10.2147/IJN.S32630
Türk M, Lietzow R (2004) Stabilized nanoparticles of phytosterol by rapid expansion from supercritical solution into aqueous solution. AAPS PharmSciTech 5:e56. https://doi.org/10.1208/pt050456
Uluata S, Decker EA, McClements DJ (2016) Optimization of Nanoemulsion fabrication using microfluidization: role of surfactant concentration on formation and stability. Food Biophys 11:52–59
Vuddanda PR, Mishra A, Singh SK, Singh S (2014) Development of polymeric nanoparticles with highly entrapped herbal hydrophilic drug using nanoprecipitation technique: an approach of quality by design. Pharm Dev Technol 20:1–9. https://doi.org/10.3109/10837450.2014.908302
Wang JC, Chen SH, ZC X (2008) Synthesis and properties research on the nanocapsulated capsaicin by simple coacervation method. J Dispers Sci Technol 29:687–695. https://doi.org/10.1080/01932690701756651
Wang LH, Che X, Xu H et al (2013) A novel strategy to design sustained-release poorly water-soluble drug mesoporous silica microparticles based on supercritical fluid technique. Int J Pharm 454:135–142. https://doi.org/10.1016/j.ijpharm.2013.07.027
Wang Y, Xu S, Xiong W et al (2016) Nanogels fabricated from bovine serum albumin and chitosan via self-assembly for delivery of anticancer drug. Colloids Surf B Biointerfaces 146:107–113
Wong TW (2016) Microwave technology enabled transdermal nanocarrier and drug delivery. Asian J Pharm Sci 11:43–44
Xie X, Tao Q, Zou Y et al (2011) PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. J Agric Food Chem 59:9280–9289. https://doi.org/10.1021/jf202135j
Xing F, Cheng G, Yi K, Ma L (2005) Nanoencapsulation of capsaicin by complex coacervation of gelatin, acacia, and tannins. J Appl Polym Sci 96:2225–2229. https://doi.org/10.1002/app.21698
Zhang YZ, Wang X, Feng Y et al (2006) Coaxial electrospinning of (fl uorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly (ε-caprolactone) nanofi bers for sustained release. Biomacromolecules 7:1049–1057
Zhang K, Tang X, Zhang J et al (2014) PEG-PLGA copolymers: their structure and structure-influenced drug delivery applications. J Control Release 183:77–86
Zhang H, Wang Z, Liu O (2016) Simultaneous determination of kolliphor HS15 and miglyol 812 in microemulsion formulation by ultra-high performance liquid chromatography coupled with nano quantity analyte detector. J Pharm Anal 6:11–17
Zhao W, Wang Y (2016) Coacervation with surfactants: from single-chain surfactants to gemini surfactants. Adv Colloid Interface Sci 239:199–212
Zhu X, Shan W, Zhang P et al (2014) Penetratin derivative-based nanocomplexes for enhanced intestinal insulin delivery. Mol Pharm 11:317–328. https://doi.org/10.1021/mp400493b
Zhu W, Masood F, O’Brien J, Zhang LG (2015) Highly aligned nanocomposite scaffolds by electrospinning and electrospraying for neural tissue regeneration. Nanomed Nanotechnol Biol Med 11:693–704. https://doi.org/10.1016/j.nano.2014.12.001
Zimet P, Livney YD (2009) Beta-lactoglobulin and its nanocomplexes with pectin as vehicles for ω-3 polyunsaturated fatty acids. Food Hydrocoll 23:1120–1126
Zou L, Zhang Z, Zhang R et al (2016) Encapsulation of protein nanoparticles within alginate microparticles: impact of pH and ionic strength on functional performance. J Food Eng 178:81–89. https://doi.org/10.1016/j.jfoodeng.2016.01.010
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Dasgupta, N., Ranjan, S. (2018). Food Engineering for Developing Food-Grade Nanoemulsions. In: An Introduction to Food Grade Nanoemulsions. Environmental Chemistry for a Sustainable World. Springer, Singapore. https://doi.org/10.1007/978-981-10-6986-4_5
Download citation
DOI: https://doi.org/10.1007/978-981-10-6986-4_5
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-6985-7
Online ISBN: 978-981-10-6986-4
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)