Initiation of DNA Replication in the Archaea

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)


Organisms within the archaeal domain of life possess a simplified version of the eukaryotic DNA replication machinery. While some archaea possess a bacterial-like mode of DNA replication with single origins of replication per chromosome, the majority of species characterized to date possess chromosomes with multiple replication origins. Genetic, structural, and biochemical studies have revealed the nature of archaeal origin specification. Recent work has begun to shed light on the mechanisms of replication initiation in these organisms.


DNA replication Initiator protein Helicase Replication origin Archaea Sulfolobus 



I would like to thank Rachel Samson for helpful discussions of this material.


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Molecular and Cellular Biochemistry, Department of BiologyIndiana UniversityBloomingtonUSA

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