Initiation of DNA Replication in the Archaea
Organisms within the archaeal domain of life possess a simplified version of the eukaryotic DNA replication machinery. While some archaea possess a bacterial-like mode of DNA replication with single origins of replication per chromosome, the majority of species characterized to date possess chromosomes with multiple replication origins. Genetic, structural, and biochemical studies have revealed the nature of archaeal origin specification. Recent work has begun to shed light on the mechanisms of replication initiation in these organisms.
KeywordsDNA replication Initiator protein Helicase Replication origin Archaea Sulfolobus
I would like to thank Rachel Samson for helpful discussions of this material.
- Kelman LM, Kelman Z (2014) Archaeal DNA replication. Annu Rev Genet 48:71–97. https://doi.org/10.1146/annurev-genet-120213-092148 CrossRefPubMedGoogle Scholar
- Lundgren M, Andersson A, Chen LM, Nilsson P, Bernander R (2004) Three replication origins in Sulfolobus species: synchronous initiation of chromosome replication and asynchronous termination. Proc Natl Acad Sci U S A 101(18):7046–7051. https://doi.org/10.1073/pnas.0400656101 CrossRefPubMedPubMedCentralGoogle Scholar
- Maaty WS, Wiedenheft B, Tarlykov P, Schaff N, Heinemann J, Robison-Cox J, Valenzuela J, Dougherty A, Blum P, Lawrence CM, Douglas T, Young MJ, Bothner B (2009) Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress. PLoS One 4(9):e6964. https://doi.org/10.1371/journal.pone.0006964 CrossRefPubMedPubMedCentralGoogle Scholar
- Majernik AI, Chong JP (2008) A conserved mechanism for replication origin recognition and binding in archaea. Biochem J 409(2):511–518Google Scholar
- Oyama T, Ishino S, Shirai T, Yamagami T, Nagata M, Ogino H, Kusunoki M, Ishino Y (2016) Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication. Nucleic Acids Res 44(19):9505–9517. https://doi.org/10.1093/nar/gkw789 CrossRefPubMedPubMedCentralGoogle Scholar
- Samel SA, Fernandez-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C (2014) A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA. Genes Dev 28(15):1653–1666. https://doi.org/10.1101/gad.242404.114 CrossRefPubMedPubMedCentralGoogle Scholar
- Tiengwe C, Marcello L, Farr H, Gadelha C, Burchmore R, Barry JD, Bell SD, McCulloch R (2012) Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS One 7(3):e32674. https://doi.org/10.1371/journal.pone.0032674 CrossRefPubMedPubMedCentralGoogle Scholar
- Xu Y, Gristwood T, Hodgson B, Trinidad JC, Albers SV, Bell SD (2016) Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM. Proc Natl Acad Sci U S A 113(47):13390–13395. https://doi.org/10.1073/pnas.1613825113 CrossRefPubMedPubMedCentralGoogle Scholar