Coordinating Replication with Transcription

  • Yathish Jagadheesh AcharEmail author
  • Marco Foiani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)


DNA topological transitions occur when replication forks encounter other DNA transactions such as transcription. Failure in resolving such conflicts leads to generation of aberrant replication and transcription intermediates that might have adverse effects on genome stability. Cells have evolved numerous surveillance mechanisms to avoid, tolerate, and resolve such replication-transcription conflicts. Defects or non-coordination in such cellular mechanisms might have catastrophic effect on cell viability. In this chapter, we review consequences of replication encounters with transcription and its associated events, topological challenges, and how these inevitable conflicts alter the genome structure and functions.


DNA replication Transcription Topology Topoisomerase Chromatin structure Genome instability RNA:DNA hybrids 



We thank Ghadeer Shubassi for helping with manuscript preparations and all the MF-lab members for discussions and valuable inputs. Research in MF-lab is supported by grants from the Associazione Italiana per la Ricerca sul Cancro (AIRC), the European Union and Telethon-Italy. YJA is supported by the European Community’s Seventh Framewok Programme under Grant agreement no.246549 – Train 2009.


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.IFOM (Fondazione Istituto FIRC di Oncologia Molecolare)MilanItaly
  2. 2.Istituto FIRC di Oncologia MolecolareMilanItaly

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