Interaction of Rif1 Protein with G-Quadruplex in Control of Chromosome Transactions

  • Kenji Moriyama
  • Mong Sing Lai
  • Hisao MasaiEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)


Recent studies on G-quadruplex (G4) revealed crucial and conserved functions of G4 in various biological systems. We recently showed that Rif1, a conserved nuclear factor, binds to G4 present in the intergenic regions and plays a major role in spatiotemporal regulation of DNA replication. Rif1 may tether chromatin fibers through binding to G4, generating specific chromatin domains that dictate the replication timing. G4 and its various binding partners are now implicated in many other chromosome regulations, including transcription, replication initiation, recombination, gene rearrangement, and transposition.


Replication timing G-quadruplex Rif1 Telomere DSB repair Nonhomologous end joining Homologous recombination 



We thank Naoko Yoshizawa-Sugata for critical reading of the manuscript. We also thank the past and present members of our laboratory for their contribution to our Rif1 studies. This work was supported by JSPS KAKENHI (Grant-in-Aid for Scientific Research (A)) [Grant Numbers 23247031 and 26251004], Grant-in-Aid for Scientific Research on Priority Areas [“non-coding RNA”; Grant Numbers 24114520], and the Uehara Memorial Foundation Research Support to H.M.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Genome MedicineTokyo Metropolitan Institute of Medical ScienceTokyoJapan

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