G-Quadruplexes and DNA Replication Origins

  • Marie-Noëlle PrioleauEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)


DNA replication ensures the accurate duplication of the genome at each cell cycle. During S phase, tens of thousands of replication origins throughout the vertebrate genome are activated according to a spatiotemporal program. The genome-wide mapping of origins in several model systems has identified G-quadruplexes—higher-order DNA structures formed from G-rich sequences—as potential key regulators of origin activity. Here, I describe genetic experiments demonstrating the role of G-quadruplexes in origin function. I discuss the different means by which G-quadruplexes might regulate origin function. Finally, comparisons of replicon organization in the three domains of life suggest that G-quadruplexes may have retained a conserved role in origin function during evolution.


Replication origin G-quadruplex Chromatin Evolution 



This work was supported by grants from the Association pour la Recherche sur le Cancer (Equipe labellisée), the Agence Nationale pour la Recherche (ANR-15-CE12-0004-01), and the IdEx Paris Sorbonne to M-N.P. M-N.P is supported by the Inserm.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Institut Jacques Monod, CNRS UMR7592, Université Paris Diderot, Equipe Labellisée Association pour la Recherche sur le CancerParisFrance

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