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Rif1-Dependent Regulation of Genome Replication in Mammals

  • Sara B. C. BuonomoEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)

Abstract

Eukaryotic genomes are replicated starting from multiple origins of replication. Their usage is tightly regulated, and not all the potential origins are activated during a single cell cycle. In addition, the ones that are activated are activated in a sequential order. Why don’t origins of replication normally all fire together? Is this important? And if so, why? Would any order of firing do, or does the specific sequence matter? How is this process regulated? These questions concern all eukaryotes but have proven extremely hard to address because replication timing is a process intricately connected with multiple aspects of nuclear function.

Keywords

DNA replication timing Nuclear architecture Rif1 Nuclear lamina Nuclear organization PP1 Origin firing Telomere replication 

Notes

Acknowledgments

I would like to thank past and present members of the Buonomo group for their work that is the base of this review and the invaluable scientific contribution. I am also grateful to Svetlana Makovets and Elizabeth Bayne for critical reading of the manuscript and helpful suggestions. I apologize for the references omitted due to general nature of this review.

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.School of Biological Sciences, Institute of Cell BiologyUniversity of EdinburghEdinburghUK

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