Historical Perspective of Eukaryotic DNA Replication

  • Thomas KellyEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)


The replication of the genome of a eukaryotic cell is a complex process requiring the ordered assembly of multiprotein replisomes at many chromosomal sites. The process is strictly controlled during the cell cycle to ensure the complete and faithful transmission of genetic information to progeny cells. Our current understanding of the mechanisms of eukaryotic DNA replication has evolved over a period of more than 30 years through the efforts of many investigators. The aim of this perspective is to provide a brief history of the major advances during this period.


DNA replication Eukaryotes Viral models Origin of DNA replication Prereplicative complex Helicase Initiator Replisome 


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkUSA

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