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Historical Perspective of Eukaryotic DNA Replication

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DNA Replication

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1042))

Abstract

The replication of the genome of a eukaryotic cell is a complex process requiring the ordered assembly of multiprotein replisomes at many chromosomal sites. The process is strictly controlled during the cell cycle to ensure the complete and faithful transmission of genetic information to progeny cells. Our current understanding of the mechanisms of eukaryotic DNA replication has evolved over a period of more than 30 years through the efforts of many investigators. The aim of this perspective is to provide a brief history of the major advances during this period.

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  1. Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Thomas Kelly

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  1. Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Hisao Masai

  2. Istituto FIRC di Oncologia Molecolare, Milan, Italy

    Marco Foiani

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Kelly, T. (2017). Historical Perspective of Eukaryotic DNA Replication. In: Masai, H., Foiani, M. (eds) DNA Replication. Advances in Experimental Medicine and Biology, vol 1042. Springer, Singapore. https://doi.org/10.1007/978-981-10-6955-0_1

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