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The Roles of Radiotherapy, Androgen Deprivation Therapy, and Their Combination for Locally Advanced Prostate Cancer

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Management of Advanced Prostate Cancer

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Abstract

Men with locally advanced or high-risk prostate cancer have a substantial risk of dying and developing distant metastases. Historically, androgen deprivation therapy (ADT) by bilateral orchiectomy was frequently used as an effective systemic treatment for advanced prostate cancer. In the 1980s, luteinizing hormone-releasing hormone (LHRH) analogs and antiandrogens emerged and have been used as a medical castration alternative to bilateral orchiectomy. After its success as a palliative treatment for metastatic prostate cancer, a number of trials were initiated to investigate the role of radiotherapy (RT), ADT, and their combination in multimodal treatment for locally advanced or high-risk prostate cancer. In this chapter, we highlighted important randomized trials of combined therapy for locally advanced or high-risk prostate cancer and tried to define the individual roles of RT, ADT, and their combination. A comprehensive review of this topic has been published elsewhere [1], and a large part of the content has been duplicated.

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Authors and Affiliations

  1. The Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Ilsandong-gu, South Korea

    Sung Uk Lee M.D. & Kwan Ho Cho M.D.

Authors
  1. Sung Uk Lee M.D.
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  2. Kwan Ho Cho M.D.
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Correspondence to Kwan Ho Cho M.D. .

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Editors and Affiliations

  1. Department of Urology, Asan Medical Center, Seoul, Soul-t´ukpyolsi, Korea (Republic of)

    Choung Soo Kim

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Lee, S.U., Cho, K.H. (2018). The Roles of Radiotherapy, Androgen Deprivation Therapy, and Their Combination for Locally Advanced Prostate Cancer. In: Kim, C. (eds) Management of Advanced Prostate Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-10-6943-7_8

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  • DOI: https://doi.org/10.1007/978-981-10-6943-7_8

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6942-0

  • Online ISBN: 978-981-10-6943-7

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