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Role of Clostridial Nitroreductases in Bioremediation

  • Razia KuttyEmail author
  • George N. Bennett
Chapter

Abstract

The use of clostridial enzymes in industry, environment, medical and economical aspects has been of immense significance and is well documented. Over decades the research has been focused on developing efficient strains and modified enzymes to be used in the bio-butanol production. The research interest in clostridial nitroreductase enzyme has increased recently due to its application in cancer treatment and bioremediation. To date, the report on the nitroreductases from Clostridium species is scarce. The function of these nitroreductases in bioremediation has been demonstrated. The structure of nitroreductases from Escherichia coli and Bacillus subtilis has been determined; however, very little documentation is available on clostridial nitroreductases. The information on the nitroreductase genes and proteins has become available from genomic and protein databases. However the significance of clostridial nitroreductases in its metabolism is not well understood. In this chapter, we discuss the findings on clostridial nitroreductases on the avenue for bioremediation and its applications in medical and industrial areas. The literature also aims to have comprehensive analysis of clostridial physiology based on the existing information.

Keywords

Bacillus Clostridium Biogas Bioremediation Digestion Environment 

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of MicrobiologySavitribai Phule Pune UniversityPuneIndia
  2. 2.Department of Biochemistry & Cell Biology MS-140Rice UniversityHoustonUSA

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