History and Traditional Techniques of Studying the Structure of Cell Membranes

  • Jing Gao
  • Hongda WangEmail author


All modern cells are delimited by cell membranes, which keep the integrity of the whole cell. The cell membrane is not only the boundary of the unit of life, but also a specific compartment that harbors many essential cellular activities. The unceasing progress of science and technology provides us a more comprehension and profound understanding of cell membranes. Here we summarize the major historical discoveries and theories that tackled the existence and structure of cell membranes, and the related techniques by which different membrane models have been proposed. We also discuss the strengths and weaknesses of the techniques and the suitability of different membrane models in various cell systems.



This work was supported by the National Key R&D Program of China (No. 2017YFA0505300), the National Natural Science Foundation of China (No. 21525314, 21703231, 21721003).


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Electroanalytical ChemistryChangchun Institute of Applied Chemistry, Chinese Academy of SciencesChangchunPeople’s Republic of China

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