Abstract
This chapter describes the lesions in the airways of the lungs, particularly those observed in bronchiolitis obliterans, in patients with rheumatoid arthritis (RA). RA-associated bronchiolitis obliterans has two different morphological presentations: (1) endobronchiolitis obliterans (EBO), in which the lesions are primarily present in the lumen of the airway, with minimal destruction of the airway wall, and (2) cellular destructive bronchiolitis (CDB), in which transmural inflammation causes destruction of the airway wall. The clinical presentations of EBO are markedly different from those of CDB, and they are generally characterized by distinct pathologies. Notably, a few cases of RA-associated bronchiectasis have been found to represent secondary lesions of CDB.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cohen M, Shan SA. Bronchiectasis in systemic disease. Chest. 1999;116:1063–74.
White ES, Tazalaar HD, Lynchi JP III. Bronchiolar complications of connective tissue diseases. Semin Respir Crit Care Med. 2003;24:543–66.
Lange W. Ueber eine eigenthuemliche Erkrankung der kleinen Bronchien und Bronchiolen. Dtsch Arch Klin Med. 1901;70:342–64.
Colby TV, Myers JL. Clinical and histologic spectrum of bronchiolitis obliterans, including bronchiolitis obliterans organizing pneumonia. Semin Respir Med. 1992;13:119–33.
Colby TV. Bronchiolar pathology. In: Epler GR, editor. Diseases of the bronchioles. New York: Raven Press; 1994. p. 77–100.
Geddes DM, Corrin B, Brewerton DA, Davies RJ, Turner-Warwick M. Progressive airway obliteration in adults and its association with rheumatoid arthritis. Q J Med. 1977;184:427–44.
Hayakawa H, Sato A, Imokawa S, Toyoshima M, Chida K, Iwata M. Bronchiolar diseases in rheumatoid arthritis. Am J Crit Care Med. 1996;154:1531–6.
Yousem SA, Colby TV, Carrington CB. Follicular bronchitis/bronchiolitis. Hum Pathol. 1985;16:700–6.
Homma S, Sakamoto S, Kawabata M, Kishi K, Tsuboi E, Motoi N, et al. Comparative clinicopathology of obliterative bronchiolitis and diffuse panbronchiolitis. Respiration. 2006;73:481–7.
Sugino K, Hebisawa A, Uekusa T, Hatanaka K, Abe H, Homma S. Histopathological bronchial reconstruction of human bronchiolitis obliterans. Path Int. 2011;61:192–201.
Morita S, Sato A, Hayakawa H, Chida K, Tsukamoto K, Toyoshima M, et al. Follicular bronchiolitis associated with rheumatoid arthritis. Nihon Kyobu Shikkan Gakkai Zasshi. 1996;34:921–5. (in Japanese; abstract in English).
Ishiguro T, Takayanagi N, Tokunaga D, Yanagisawa T, Sugita Y, Kawabata Y. A case of follicular bronchiolitis in which progressive bronchiectasis developed over 7 years. Nihon Kokyuki Gakkai Zasshi. 2011;49:827–32. (in Japanese; abstract in English).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Hebisawa, A., Kitani, M., Matsui, H., Tamura, A. (2018). Pathology of Airway Disease in Rheumatoid Arthritis. In: Gono, T., Tokuda, H., Sakai, F., Takemura, T. (eds) Lung Disease Associated with Rheumatoid Arthritis. Springer, Singapore. https://doi.org/10.1007/978-981-10-6750-1_3
Download citation
DOI: https://doi.org/10.1007/978-981-10-6750-1_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-6749-5
Online ISBN: 978-981-10-6750-1
eBook Packages: MedicineMedicine (R0)