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Comprehensive Understanding of Airway Disease in Rheumatoid Arthritis

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Lung Disease Associated with Rheumatoid Arthritis

Abstract

Although the high prevalence of airway diseases in patients with rheumatoid arthritis (RA) has been recognized for decades, their clinical significance and treatment strategies have not been well discussed. With the introduction of potent disease-modifying treatments for RA, respiratory complications have emerged as the most important obstacle impeding the safe implementation of these therapies and improvement of patient prognosis. Along with interstitial lung disease, airway diseases are now regarded as one of the major risk factors of these lung complications and also result in their own problems such as airway obstruction and lung destruction. Bronchiectasis (BE) and bronchiolitis are well-known airway diseases that often develop concurrently. They are found in more than 10–30% of RA subjects and are thought to be caused by persistent inflammation of the airway attributed to the dysregulated immune response in RA. Not infrequently, airway inflammation may provoke destruction of the peripheral airway and lung parenchyma, leading to the formation of a honeycomb-like structure mimicking interstitial lung disease. Control of this inflammation is an urgent issue that needs to be addressed in the future.

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Author information

Authors and Affiliations

  1. Department of Respiratory Medicine, Tokyo Yamate Medical Center, Japan Community Health Care Organization (JCHO), Tokyo, Japan

    Hitoshi Tokuda M.D., Ph.D.

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  1. Hitoshi Tokuda M.D., Ph.D.
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Correspondence to Hitoshi Tokuda M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan

    Takahisa Gono

  2. Department of Respiratory Medicine, JCHO Tokyo Yamate Medical Center, Tokyo, Japan

    Hitoshi Tokuda

  3. Department of Diagnostic Radiology, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan

    Fumikazu Sakai

  4. Department of Pathology , Japanese Red Cross Medical Center, Tokyo, Japan

    Tamiko Takemura

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Tokuda, H. (2018). Comprehensive Understanding of Airway Disease in Rheumatoid Arthritis. In: Gono, T., Tokuda, H., Sakai, F., Takemura, T. (eds) Lung Disease Associated with Rheumatoid Arthritis. Springer, Singapore. https://doi.org/10.1007/978-981-10-6750-1_2

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  • DOI: https://doi.org/10.1007/978-981-10-6750-1_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6749-5

  • Online ISBN: 978-981-10-6750-1

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