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Organizing Pneumonia in Rheumatoid Arthritis

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Lung Disease Associated with Rheumatoid Arthritis

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Abstract

Organizing pneumonia (OP) is one of the extra-articular manifestations in rheumatoid arthritis (RA). OP is noninfectious pneumonia with less responsiveness to antibiotics, occasionally mimicking bacterial pneumonia. RA patients with OP typically experience flu-like symptoms and respiratory symptoms such as nonproductive cough and dyspnea at the onset of OP. However, some RA patients do not reveal any respiratory symptoms. The characteristics of chest imaging include bilateral/multiple consolidations or ground-glass opacities with normal lung volumes. The lung lesions are occasionally unilateral/solitary and are frequently observed in the lower zone of the lungs. In the pathophysiology of OP with RA, Th1-dominant response and pro-inflammatory cytokines are associated with the development of OP with RA.

In general, intermediate–high dose of prednisolone ameliorates OP with RA. The prognosis is good for OP with RA, although OP relapse is noted in 10–20% of RA-OP cases. OP is not a direct cause of death in RA.

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References

  1. Kelmenson LB, Demoruelle MK, Deane KD. The complex role of the lung in the pathogenesis and clinical outcomes of rheumatoid arthritis. Curr Rheumatol Rep. 2016;18:69.

    Article  PubMed  Google Scholar 

  2. Baque-Juston M, Pellegrin A, Leroy S, Marquette CH, Padovani B. Organizing pneumonia: what is it? A conceptual approach and pictorial review. Diagn Interv Imaging. 2014;95:771–7.

    Article  CAS  PubMed  Google Scholar 

  3. Cordier JF. Cryptogenic organising pneumonia. Eur Respir J. 2006;28:422–46.

    Article  PubMed  Google Scholar 

  4. Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, Ascherman DP, Glassberg MK, Ryu JH, Danoff SK, Brown KK, Collard HR, Rosas IO. A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest. 2014;145:454–63.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Gabbay E, Tarala R, Will R, Carroll G, Adler B, Cameron D, Lake FR. Interstitial lung disease in recent onset rheumatoid arthritis. Am J Respir Crit Care Med. 1997;156:528–35.

    Article  CAS  PubMed  Google Scholar 

  6. Demoruelle MK, Mittoo S, Solomon JJ. Connective tissue disease-related interstitial lung disease. Best Pract Res Clin Rheumatol. 2016;30:39–52.

    Article  PubMed  Google Scholar 

  7. Kelly CA, Saravanan V, Nisar M, Arthanari S, Woodhead FA, Price-Forbes AN, Dawson J, Sathi N, Ahmad Y, Koduri G, Young A, Network BRILB. Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics—a large multicentre UK study. Rheumatology (Oxford). 2014;53:1676–82.

    Article  CAS  Google Scholar 

  8. Okada H, Kurasawa K, Yamazaki R, Tanaka A, Arai S, Owada T, Maezawa R, Ishii Y. Clinical features of organizing pneumonia associated with rheumatoid arthritis. Mod Rheumatol. 2016;1–6.

    Google Scholar 

  9. Mori S, Koga Y, Sugimoto M. Organizing pneumonia in rheumatoid arthritis patients: a case-based review. Clin Med Insights Circ Respir Pulm Med. 2015;9:69–80.

    PubMed  PubMed Central  Google Scholar 

  10. Kawasumi H, Gono T, Tanaka E, Kaneko H, Kawaguchi Y, Yamanaka H. Clinical characteristics and cytokine profiles of organizing pneumonia in patients with rheumatoid arthritis treated with or without biologics. J Rheumatol. 2016;43:738–44.

    Article  PubMed  Google Scholar 

  11. Ulubaş B, Sahin G, Ozer C, Aydin O, Ozgür E, Apaydin D. Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis. Clin Rheumatol. 2004;23:249–51.

    Article  PubMed  Google Scholar 

  12. Kajiya T, Kuroda A, Hokonohara D, Tei C. Radiographic appearance of bronchiolitis obliterans organizing pneumonia (BOOP) developing during Bucillamine treatment for rheumatoid arthritis. Am J Med Sci. 2006;332:39–42.

    Article  PubMed  Google Scholar 

  13. Cho SK, IH O, Park CK, Bae SC, Sung YK. Etanercept induced organizing pneumonia in a patient with rheumatoid arthritis. Rheumatol Int. 2012;32:1055–7.

    Article  CAS  PubMed  Google Scholar 

  14. Ikegawa K, Hanaoka M, Ushiki A, Yamamoto H, Kubo K. A case of organizing pneumonia induced by tocilizumab. Intern Med. 2011;50:2191–3.

    Article  CAS  PubMed  Google Scholar 

  15. https://www.uptodate.com/contents/cryptogenic-organizing-pneumonia.

  16. Roberton BJ, Hansell DM. Organizing pneumonia: a kaleidoscope of concepts and morphologies. Eur Radiol. 2011;21:2244–54.

    Article  PubMed  Google Scholar 

  17. Cordier JF. Organising pneumonia. Thorax. 2000;55:318–28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. King TE, Mortenson RL. Cryptogenic organizing pneumonitis. The North American experience. Chest. 1992;102:8S–13S.

    Article  PubMed  Google Scholar 

  19. Cazzato S, Zompatori M, Baruzzi G, Schiattone ML, Burzi M, Rossi A, Ratta L, Terzuolo G, Falcone F, Poletti V. Bronchiolitis obliterans-organizing pneumonia: an Italian experience. Respir Med. 2000;94:702–8.

    Article  CAS  PubMed  Google Scholar 

  20. Forlani S, Ratta L, Bulgheroni A, Cascina A, Paschetto E, Cervio G, Luinetti O, Fietta AM, Meloni F. Cytokine profile of broncho-alveolar lavage in BOOP and UIP. Sarcoidosis Vasc Diffuse Lung Dis. 2002;19:47–53.

    PubMed  Google Scholar 

  21. Aguiar M, Felizardo M, Mendes AC, Moniz D, Sotto-Mayor R, Bugalho de Almeida A. Organising pneumonia—the experience of an outpatient clinic of a central hospital. Rev Port Pneumol. 2010;16:369–89.

    Article  PubMed  Google Scholar 

  22. Katayama H, Yokoyama A, Hamada H, Irita J, Kadowaki T, Ito R, Onishi H, Watanabe A, Mutsukado Y, Kukita H, Hiwada K, Higaki J. [Successful treatment of bronchiolitis obliterans organizing pneumonia with cyclosporin and steroids]. Nihon Kokyuki Gakkai Zasshi. 2003;41: 551–5.

    Google Scholar 

  23. Schlesinger C, Koss MN. The organizing pneumonias: a critical review of current concepts and treatment. Treat Respir Med. 2006;5:193–206.

    Article  CAS  PubMed  Google Scholar 

  24. Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol. 2012;13:722–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Romagnani S. The Th1/Th2 paradigm. Immunol Today. 1997;18:263–6.

    Article  CAS  PubMed  Google Scholar 

  26. Cheng CC, Lee YF, Lin NN, CL W, Tung KC, Chiu YT. Bronchiolitis obliterans organizing pneumonia in Swine associated with porcine circovirus type 2 infection. J Biomed Biotechnol. 2011;2011:245728.

    Article  PubMed  Google Scholar 

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Acknowledgments

I would like to thank Masanori Hanaoka and Tamiko Takemura for providing the chest imaging and the pulmonary pathology, respectively.

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Authors and Affiliations

  1. Department of Allergy and Rheumatology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan

    Takahisa Gono M.D., Ph.D.

Authors
  1. Takahisa Gono M.D., Ph.D.
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Correspondence to Takahisa Gono M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan

    Takahisa Gono

  2. Department of Respiratory Medicine, JCHO Tokyo Yamate Medical Center, Tokyo, Japan

    Hitoshi Tokuda

  3. Department of Diagnostic Radiology, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan

    Fumikazu Sakai

  4. Department of Pathology , Japanese Red Cross Medical Center, Tokyo, Japan

    Tamiko Takemura

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Gono, T. (2018). Organizing Pneumonia in Rheumatoid Arthritis. In: Gono, T., Tokuda, H., Sakai, F., Takemura, T. (eds) Lung Disease Associated with Rheumatoid Arthritis. Springer, Singapore. https://doi.org/10.1007/978-981-10-6750-1_12

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  • DOI: https://doi.org/10.1007/978-981-10-6750-1_12

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6749-5

  • Online ISBN: 978-981-10-6750-1

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