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Role and Regulation of Transcriptional Factors in Gastric Cancer

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Role of Transcription Factors in Gastrointestinal Malignancies

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Abstract

Gastric cancer is the second major cancer diagnosed worldwide. Cytokines, chemokines, metalloproteinases, prostaglandins, and reactive oxygen nitrogen species induce, amplify, and sustain inflammation (in the lining of the stomach) in the host. Signalling pathways like β-catenin, NF-κB, etc. bring about changes in the genetic material leading to diversification of genetic material. Genetic diversification in oncogenes and tumour suppressor genes leads to gastric cancer. Transcriptional factors’ role in apoptosis, cell cycle, cell proliferation, and metastasis (adhesion, invasion, migration, angiogenesis) is well known and established. The role and regulation of transcriptional factors in relation to gastric cancer was reviewed.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Acknowledgements

Nageswara Rao Reddy Neelapu thanks Gandhi Institute of Technology and Management (GITAM), Visakhapatnam, India. The author is thankful to Dr. Challa Surekha for the suggestions on manuscript. The author is also thankful to former Head of the Department Prof. I Bhaskar Reddy and present Head of the Department Prof. Malla Rama Rao for the support.

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  1. Department of Biochemistry and Bioinformatics, School of Life Sciences, GITAM Institute of Science, Gandhi Institute of Technology and Management (GITAM), Visakhapatnam, Andhra Pradesh, India

    Nageswara Rao Reddy Neelapu

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  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Neelapu, N.R.R. (2017). Role and Regulation of Transcriptional Factors in Gastric Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_9

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