Genistein and Its Role in Regulation of AP-1 in Colorectal Cancer

  • Neha Merchant
  • Ganji Lakshmi Vara Prasad
  • Ganji Purnachandra NagarajuEmail author


Colorectal cancer (CRC) is a prominent source of cancer-related deaths across the world. AP-1 is involved in CRC growth and metastasis. AP-1 is a transcription factor that regulates many oncogenic transduction pathways. In the current chapter, we discuss the importance of AP-1 on CRC growth and metastasis. Additionally, we discuss the mechanism of genistein, a tyrosine kinase inhibitor, and its effect on CRC treatment.


Genistein Colorectal cancer (CRC) Activator protein-1 (AP-1) 


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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Neha Merchant
    • 1
  • Ganji Lakshmi Vara Prasad
    • 2
  • Ganji Purnachandra Nagaraju
    • 1
    Email author
  1. 1.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA
  2. 2.Dr. LV Prasad Diagnostics and Research LaboratoryHyderabad-04APIndia

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