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Role of Transcription Factors in Gastrointestinal Malignancies pp 73–89Cite as

HIF-1α: Its Role in Metastasis of Oesophageal Malignancy

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Abstract

Hypoxia is a significant factor of the tumor microenvironment. Transcriptional factor HIF-1α serves as a drive for tumor hypoxic microenvironment and triggers gene transcription that intricate in important aspects of cancer biology. Hypoxic effects can be either positive or negative, depending on the context, severity and duration on a tissue. In oesophagus cancer, hypoxia stabilizes the transcription factor HIF-1α and regulates diverse functions such as metastasis, angiogenesis, cell cycle regulation and apoptosis chemo-resistance. miRNAs also play essential roles in the adaptive response of tumors to hypoxia. Therefore, HIF-1α acts as a promising target in advancement of new therapeutics for oesophagus cancer therapy. Recent developments in regulation of HIF-1α and functional involvement in tumor growth, migration, stemness and drugs affecting HIF-1α expression will be discussed in this review.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Authors and Affiliations

  1. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    A. M. V. N. Prathyusha, Godi Raghu & Pallaval Veera Bramhachari

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  1. A. M. V. N. Prathyusha
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  2. Godi Raghu
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  3. Pallaval Veera Bramhachari
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Correspondence to Pallaval Veera Bramhachari .

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  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Prathyusha, A.M.V.N., Raghu, G., Bramhachari, P.V. (2017). HIF-1α: Its Role in Metastasis of Oesophageal Malignancy. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_6

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