NF-κB Role and Potential Drug Targets in Gastrointestinal Cancer

  • Prudhvi Lal BhukyaEmail author
  • Rongala Laxmivandana
  • Gopinath Meenakshi Sundaram


A multifactorial disease cancer arises due to mutation in the gene encoding particular transcription factor or proteins. Globally cancer is one of the diseases which is responsible for maximum mortality annually. Transcription factor plays an important role in cell physiology, and any alteration in this transcription factor may lead to diseases like cancers. NF-κB is a transcription factor which has immense homeostasis role in cell physiology and in several diseases. NF-κB is actively expressed in many cancers and helps in initiations, cell proliferations, and metastasis of different cancers. The present chapter discusses the role of NF-κB in cancer promotion and different drug targets, targeting NF-κB pathway for the treatment of cancers.


NF-κB Carcinogenesis Treatment Noncanonical pathway and canonical pathways 


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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Prudhvi Lal Bhukya
    • 1
    Email author
  • Rongala Laxmivandana
    • 2
  • Gopinath Meenakshi Sundaram
    • 3
  1. 1.National Institute of VirologyPuneIndia
  2. 2.ICAR-IIABRanchiIndia
  3. 3.Institute of Medical BiologyAgency for Science Technology & Research (A*STAR)SingaporeSingapore

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