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Role of Sp1 in Liver Cancer

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Role of Transcription Factors in Gastrointestinal Malignancies

Abstract

Liver cancer is one of the most serious public health concerns in the world with unhealthy lifestyle and infection with oncogenic viruses contributing to tumorigenesis. Hepatocellular carcinoma (HCC) which originates from the hepatocytes is the most ubiquitous form of liver cancer and is the sixth most prevalent cancer globally. The specificity protein 1 (Sp1) transcription factor occupies an important functional niche in varied cellular processes including cell division, differentiation, cell adhesion, immune response, apoptosis, chromatin remodeling, and DNA damage response. Considering the central position of Sp1 in the life cycle of cells, it is conceivable that Sp1 could be intimately associated with the process of transformation. Some of the pharmacological agents exert their antineoplastic effects through the inhibition of Sp1 response, thereby underlining the importance of Sp1 in the process of carcinogenesis. Over the years, evidence has built up implicating the role of Sp1 in various features of tumorigenesis including proliferation of cancerous cells, cell cycle regulation, invasion and metastasis, angiogenesis, and apoptosis. This review evaluates the contributions of Sp1 to various aspects of HCC.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Authors and Affiliations

  1. Sysmex India Private Limited, Mumbai, India

    Himanshu Tillu

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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  1. Himanshu Tillu
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Correspondence to Pallaval Veera Bramhachari .

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  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Tillu, H., Bramhachari, P.V. (2017). Role of Sp1 in Liver Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_37

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