Role of Curcumin: A Suppressor of NF-κB Activity in Hepatocellular Carcinoma

  • Saipriya Lammata
  • Mundla Srilatha
  • Ganji Purnachandra NagarajuEmail author


Leading as the third cause of cancer-related deaths in the world, hepatocellular carcinoma (HCC) is an aggressive cancer that offers little to no treatment for patients in the advanced stages due to the frequency of recurrence. Moreover, the upregulation of the nuclear factor-kappaB (NF-κB) signaling pathway leads to uncontrolled cell growth, metastasis, and resistance in HCC. Curcumin, a polyphenol derived from turmeric, has been found to inhibit NF-κB activity in HCC and to present other antitumor properties such as anti-proliferation, anti-inflammation, and anti-angiogenic properties. Furthermore, curcumin also acts as a collaborative agent with available chemotherapy and radiotherapy. Working against the drawbacks of poor bioavailability and rapid metabolism, researchers are discovering new ways of encapsulating curcumin in order to exhibit its full efficacy against HCC metastasis.


Curcumin NF-κB pathway Hepatocellular carcinoma Angiogenesis Chemotherapy 



Protein kinase B


Basic fibroblast growth factors




Fibrolamellar hepatocellular carcinoma


Protein X of the hepatitis B virus


Hepatocellular Carcinoma




Inhibitors of NF-κB


IκB kinase


Nuclear Factor-kappaB


Programmed cell death


Percutaneous ethanol injection


Peroxisome proliferator-activated receptor-γ




Vascular endothelial growth factor


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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Saipriya Lammata
    • 1
  • Mundla Srilatha
    • 2
  • Ganji Purnachandra Nagaraju
    • 3
    Email author
  1. 1.Rice UniversityHoustonUSA
  2. 2.Department of BiotechnologySri Venkateswara UniversityTirupatiIndia
  3. 3.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA

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