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Role of Curcumin: A Suppressor of NF-κB Activity in Hepatocellular Carcinoma

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Role of Transcription Factors in Gastrointestinal Malignancies

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Abstract

Leading as the third cause of cancer-related deaths in the world, hepatocellular carcinoma (HCC) is an aggressive cancer that offers little to no treatment for patients in the advanced stages due to the frequency of recurrence. Moreover, the upregulation of the nuclear factor-kappaB (NF-κB) signaling pathway leads to uncontrolled cell growth, metastasis, and resistance in HCC. Curcumin, a polyphenol derived from turmeric, has been found to inhibit NF-κB activity in HCC and to present other antitumor properties such as anti-proliferation, anti-inflammation, and anti-angiogenic properties. Furthermore, curcumin also acts as a collaborative agent with available chemotherapy and radiotherapy. Working against the drawbacks of poor bioavailability and rapid metabolism, researchers are discovering new ways of encapsulating curcumin in order to exhibit its full efficacy against HCC metastasis.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Abbreviations

Akt:

Protein kinase B

bFGF:

Basic fibroblast growth factors

COX-2:

Cyclooxygenase-2

FLHCC:

Fibrolamellar hepatocellular carcinoma

HBx:

Protein X of the hepatitis B virus

HCC:

Hepatocellular Carcinoma

HHC:

Hexahydrocurcumin

IκBs:

Inhibitors of NF-κB

IKK:

IκB kinase

NF-κB:

Nuclear Factor-kappaB

PCD:

Programmed cell death

PEI:

Percutaneous ethanol injection

PPAR-γ:

Peroxisome proliferator-activated receptor-γ

THC:

Tetrahydrocurcumin

VEGF:

Vascular endothelial growth factor

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Author information

Authors and Affiliations

  1. Rice University, Houston, TX, USA

    Saipriya Lammata

  2. Department of Biotechnology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India

    Mundla Srilatha

  3. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

Authors
  1. Saipriya Lammata
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  2. Mundla Srilatha
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  3. Ganji Purnachandra Nagaraju
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Correspondence to Ganji Purnachandra Nagaraju .

Editor information

Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Lammata, S., Srilatha, M., Nagaraju, G.P. (2017). Role of Curcumin: A Suppressor of NF-κB Activity in Hepatocellular Carcinoma. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_33

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