Targeting Arachidonic Acid Pathway-Associated NF-κB in Pancreatic Cancer

  • Nagendra Sastry YarlaEmail author
  • Olga Sukocheva
  • Ilaria Peluso
  • Swathi Putta
  • Pallaval Veera Bramhachari
  • Rajesh Yadala
  • Dinesh K. Tiwari
  • Srinivas Jagarlamudi
  • Luciana Scotti
  • Marcus T. Scotti
  • Marcella Reale
  • Mohammad Amjad Kamal
  • Ashraf Ghulam
  • Bechan Sharma
  • Madhukiran Parvathaneni
  • Chinthalapally V. Rao
  • Mastan Mannarapu
  • Anupam Bishayee


Pancreatic cancer is one of the foremost causes of cancer-related death in the United States and worldwide. Nuclear factor-kappa B (NF-κB) is a transcription factor which plays a pivotal involvement in pancreatic cancer owing to its connection at the downstream stage of many signaling cascades including arachidonic acid (AA) pathway. AA cascade is an upstream pathway and regulator of NF-κB pathway. Moreover, NF-κB can bind to the cis-acting elements in the promoter of phospholipase A2s, cyclooxygenases, and lipoxygenases, and these pathways are upregulated in a variety of cancers. Several investigators have proved that AA pathway-associated NF-κB has key role in pathophysiology of pancreatic cancer and has been considered as a vital therapeutic target. Several phytochemicals have been explored as novel therapeutic and preventive agents by targeting AA cascade-associated NF-κB pathway. In this chapter, the role of AA cascade-associated NF-κB pathway in pancreatic cancer has been reviewed and discussed about plant-derived inhibitors of this pathway for the prevention and the therapy of pancreatic cancer.


NF-κB Arachidonic acid pathway Pancreatic cancer Natural products 


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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Nagendra Sastry Yarla
    • 1
    Email author
  • Olga Sukocheva
    • 2
  • Ilaria Peluso
    • 3
  • Swathi Putta
    • 4
  • Pallaval Veera Bramhachari
    • 5
  • Rajesh Yadala
    • 1
  • Dinesh K. Tiwari
    • 1
  • Srinivas Jagarlamudi
    • 1
  • Luciana Scotti
    • 6
  • Marcus T. Scotti
    • 6
  • Marcella Reale
    • 7
  • Mohammad Amjad Kamal
    • 8
    • 9
    • 10
  • Ashraf Ghulam
    • 8
  • Bechan Sharma
    • 11
  • Madhukiran Parvathaneni
    • 12
  • Chinthalapally V. Rao
    • 13
  • Mastan Mannarapu
    • 14
  • Anupam Bishayee
    • 15
  1. 1.School of Life SciencesUniversity of HyderabadHyderabadIndia
  2. 2.School of Health SciencesFlinders University of South AustraliaAdelaideAustralia
  3. 3.Research Centre for Food and Nutrition, Council for Agricultural Research and EconomicsRomeItaly
  4. 4.Department of Pharmaceutical SciencesUniversity College of Pharmaceutical Sciences, Andhra UniversityVisakhapatnamIndia
  5. 5.Department of BiotechnologyKrishna UniversityMachilipatnamIndia
  6. 6.Federal University of ParaibaJoão PessoaBrazil
  7. 7.Department of Medical, Oral and Biotechnological SciencesUniversity “G. D’Annunzio”ChietiItaly
  8. 8.King Fahd Medical Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia
  9. 9.Enzymoics, 7 Peterlee PlaceHebershamAustralia
  10. 10.Novel Global Community Educational FoundationHebershamAustralia
  11. 11.Department of BiochemistryUniversity of AllahabadAllahabadIndia
  12. 12.Department of BiotechnologyHarrisburg University of Science and TechnologyHarrisburgUSA
  13. 13.Center for Cancer Prevention and Drug Development, Department of Medicine, Hematology/Oncology SectionUniversity of Oklahoma Health Sciences Center (OUHSC)Oklahoma CityUSA
  14. 14.Department of BiotechnologyDravidian University KuppamChittoorIndia
  15. 15.Department of Pharmaceutical Sciences, College of PharmacyLarkin UniversityMiamiUSA

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