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Role of Transcription Factors in Gastrointestinal Malignancies pp 371–378Cite as

Hypoxia-Inducible Factor (HIF)-1α and Its Regulation in Pancreatic Cancer

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Abstract

Pancreatic malignancy is a highly metastatic disease with a poor prognosis and extremely low overall survival rates. Despite recent advancements in the traditional chemopreventive approaches for pancreatic cancer (PC), there has been very little improvement in the overall survival rates for patients (Guilford JM, Pezzuto JM, Expert Opin Investig Drugs 17:1341–1352, 2008). Therefore, novel phytochemicals such as curcumin and genistein have emerged as promising targets in developing treatment options for patients with PC. Curcumin is a natural compound found in turmeric (Kunnumakkara AB, Guha S, Krishnan S et al, Cancer Res 67:3853–3861, 2007), and genistein is an isoflavone found in soybeans (Banerjee S, Zhang Y, Ali S et al, Cancer Res 65:9064–9072, 2005). Both compounds are known to possess outstanding anti-inflammatory, antioxidant, and anticancer properties.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA

    Ganji Purnachandra Nagaraju

  2. Department of Zoology and Department of Biotechnology, Berhampur University, Berhampur, Odisha, India

    Ganji Purnachandra Nagaraju & Subasini Pattnaik

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  1. Ganji Purnachandra Nagaraju
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  2. Subasini Pattnaik
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Correspondence to Ganji Purnachandra Nagaraju or Subasini Pattnaik .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Nagaraju, G.P., Pattnaik, S. (2017). Hypoxia-Inducible Factor (HIF)-1α and Its Regulation in Pancreatic Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_27

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