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Role of Transcription Factors in Gastrointestinal Malignancies pp 327–339Cite as

NF-κB: Its Role in Pancreatic Cancer

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Abstract

Nuclear factor κB (NF-κB) is one of the transcription factors involved in the progression of pancreatic cancer. Pancreatic cancer (PC) is a deadly cancer in today’s world, and treatment approaches become critical due to poor prognosis and chemoresistance of the cancer. The NF-κB signaling pathway is known to induce cell proliferation and metastasis, including migration and angiogenesis. Furthermore, the NF-κB pathway is also involved in the prevention of apoptosis in PC. In this present chapter, we discuss the role of NF-κB in the progression of PC, resistance to chemo drugs such as gemcitabine, and the influence of downstream targets on the metastatic characteristics of cancer. Therefore, targeting the NF-κB signaling pathway stands as a rational approach for future treatment of pancreatic cancer.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Authors and Affiliations

  1. Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK

    Appiya Santharam Madanraj

  2. Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA

    Saipriya Laxmi Lammata & Ganji Purnachandra Nagaraju

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  1. Appiya Santharam Madanraj
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  2. Saipriya Laxmi Lammata
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  3. Ganji Purnachandra Nagaraju
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Correspondence to Ganji Purnachandra Nagaraju .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Madanraj, A.S., Lammata, S.L., Nagaraju, G.P. (2017). NF-κB: Its Role in Pancreatic Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_23

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