NF-κB: Its Role in Pancreatic Cancer

  • Appiya Santharam Madanraj
  • Saipriya Laxmi Lammata
  • Ganji Purnachandra NagarajuEmail author


Nuclear factor κB (NF-κB) is one of the transcription factors involved in the progression of pancreatic cancer. Pancreatic cancer (PC) is a deadly cancer in today’s world, and treatment approaches become critical due to poor prognosis and chemoresistance of the cancer. The NF-κB signaling pathway is known to induce cell proliferation and metastasis, including migration and angiogenesis. Furthermore, the NF-κB pathway is also involved in the prevention of apoptosis in PC. In this present chapter, we discuss the role of NF-κB in the progression of PC, resistance to chemo drugs such as gemcitabine, and the influence of downstream targets on the metastatic characteristics of cancer. Therefore, targeting the NF-κB signaling pathway stands as a rational approach for future treatment of pancreatic cancer.


Pancreatic cancer NF-κB Cell growth Metastasis Epigenetics 


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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Appiya Santharam Madanraj
    • 1
  • Saipriya Laxmi Lammata
    • 2
  • Ganji Purnachandra Nagaraju
    • 2
    Email author
  1. 1.Department of Infection, Immunity and InflammationUniversity of LeicesterLeicesterUK
  2. 2.Department of Hematology and Medical OncologyWinship Cancer Institute of Emory UniversityAtlantaUSA

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