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Role of Transcription Factors in Gastrointestinal Malignancies pp 315–325Cite as

LEF/TCF: Its Role in Colon Cancer

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Abstract

Many advances have been made in understanding the role of transcription factors in different types of cancer. With colorectal cancer being the third most commonly diagnosed cancer, studying critical transcription factors such as the lymphoid enhancer factor/T-cell factor (LEF/TCF) transcription factor family may assist in understanding its growth and progression but also serve as a therapeutic target in hopes for better patient outcomes. This chapter will discuss the pathway LEF/TCF transcription factors are known to be involved in, their regulation, and current studies that have investigated their role and function in colorectal cancer and normal cell maintenance.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Authors and Affiliations

  1. Geisel School of Medicine at Dartmouth University, Hanover, NH, USA

    Amanda Joy Bastien

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  1. Amanda Joy Bastien
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Correspondence to Amanda Joy Bastien .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Bastien, A.J. (2017). LEF/TCF: Its Role in Colon Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_22

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