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Role of Notch Signaling in Colorectal Cancer

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Role of Transcription Factors in Gastrointestinal Malignancies

Abstract

Notch signaling is a simple pathway in its mechanism and complex because it activates many genes at transcriptional level. Notch plays an imperative role in embryogenesis and progenitor/stem cell maintenance and critically preserves the balance between a cell proliferation, differentiation, and apoptosis. Mutation and deregulation of Notch will be a reason for many diseases including cancer. Aberrantly expressed Notch involves in the carcinogenesis of many cancers such as colorectal cancer (CRC), breast cancer, pancreatic cancer, prostate cancer, liver cancer, cervical cancer, Ewing sarcoma, Kaposi’s sarcoma, lung cancer, ovarian cancer, and lymphoma. Among these, Notch plays a major role in CRC from development to metastasis. CRC occurs when the lining of colon epithelial cells becomes neoplasm, and this happens when the poise is missing between the normal and cancerous condition due to the overexpression of Notch. In CRC Notch promotes the stemness and epithelial to mesenchymal transition (EMT) which are requiring in aberrant crypt formation, invasion, and metastasis, respectively. Moreover, overexpression of Notch in CRC is connected with poor prognosis and chemoresistance. Notch counteracts with Hippo/YAP, WNT, NFkB, PI3K/Akt, and EGFR pathways for tumor initiation and development. Tumors are dependent on angiogenic switch for development and invasion which is activated by Notch ligand Dll-4 by overexpressing vascular endothelial growth factor (VEGF). This review will be focusing on the uniqueness of Notch in CRC.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Author information

Authors and Affiliations

  1. Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

    Divya Thirumalaipillai Rajendran, Boopathi Subramaniyan & Mathan Ganeshan

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  1. Divya Thirumalaipillai Rajendran
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  2. Boopathi Subramaniyan
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  3. Mathan Ganeshan
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Correspondence to Mathan Ganeshan .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Rajendran, D.T., Subramaniyan, B., Ganeshan, M. (2017). Role of Notch Signaling in Colorectal Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_21

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