Abstract
E2F family of transcription factor acts as central modulator for important cellular events including cell cycle progression, apoptosis, and DNA damage response. E2F1 regulates G1/S-phase transition of cell cycle transactivating a variety of genes involved in chromosomal DNA replication, including its own promoter. E2F1 is regulated in a cell cycle-dependent manner, principally through its temporal association with pocket protein family member, retinoblastoma. Pocket proteins, in turn, regulated through phosphorylation by cyclin-dependent kinase (CDK). Different E2F family exhibits distinct cell cycle and apoptotic activities. This review focuses on E2F1 function and its putative role in colon cancer.
The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39
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Vasavi, I. et al. (2017). E2F1: Transcriptional Machinery in Colon Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_20
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DOI: https://doi.org/10.1007/978-981-10-6728-0_20
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