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YY1 and KLF4: Their Role in Gastrointestinal Malignancies

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Role of Transcription Factors in Gastrointestinal Malignancies

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Abstract

Gastrointestinal (GI) malignancies are among the most serious threats to global health and are among the major causes of morbidity and mortality. KLF4 and YY1 occupy a central niche and can influence the process of oncogenesis of the various tissues of the GI tract in a major way by being closely associated with several cellular processes such as cell proliferation, differentiation, DNA repair, epigenetic modifications, and apoptosis. Although evidence over the years has implicated KLF4 and YY1 in the process of tumorigenesis, significant loopholes still remain. This review is an attempt to evaluate the relative contributions of KLF4 and YY1 to various aspects of GI malignancies.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Authors and Affiliations

  1. Sysmex India Private Limited, Mumbai, India

    Himanshu Tillu

  2. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA

    Ganji Purnachandra Nagaraju

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  1. Himanshu Tillu
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  2. Ganji Purnachandra Nagaraju
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Correspondence to Ganji Purnachandra Nagaraju .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Tillu, H., Nagaraju, G.P. (2017). YY1 and KLF4: Their Role in Gastrointestinal Malignancies. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_2

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